Clinical, cardiological and serologic follow-up of Chagas Disease in children and adolescents from the Amazon Region, Brazil: longitudinal study

• Autor(a) principal: Pinto, Ana Yecê das Neves
• Data de Publicação: 2020
• Outros Autores: Valente, Vera da Costa, Valente, Sebastião Aldo da Silva, Motta, Tamires Anastácia Rodrigues, Ventura, Ana Maria Revorêdo da Silva
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: http://patua.iec.gov.br//handle/iec/4191
• topic: Doença de Chagas / transmissão; Doença de Chagas / complicações; Trypanosoma cruzi / parasitologia; Doenças Negligenciadas

Background:Outbreaks of Chagas disease (CD) by foodborne transmission is a problem related to deforestation, exposing people to triatomines infected by T. cruzi, in the Amazon region. Once involving long-time follow-up, the treatment efficacy of the CD during its acute phase is still unknown. The authors aim to describe the clinical and epidemiologic profile of children and adolescents with CD, as well as treatment and cardiac involvement during the follow-up.Methods: A descriptive cohort study was conducted from 1998 to 2013 among children and adolescents up to 18 years-old with confirmed diagnosis of CD. All participants met the criteria of CD in the acute phase.Results: A total of 126 outpatients were included and received treatment and follow-up examinations during a medium period of 10.9 years/person. Most of them (68.3%) had their diagnosis established during oral transmission outbreaks. The diagnostic method with the most positive results rate (80.9%) was the IgM class anti-T. cruziantibody test as an acute phase marker, followed by the thick blood smears (60.8%). Acute myopericarditis was demonstrated in 18.2% of the patients, most of them with favorable evolution, though 2.4% (3/126) persisted with cardiac injury observed at the end point of the follow-up.Conclusions: Antibodies againstT. cruzipersisted in 54.8% of sera from the patients without prognostic correlation with cardiac involvement. Precocious treatment can decrease potential cardiac complications and assure good treatment response, especially for inhabitants living in areas with difficult accessibility.