Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3561 |
Resumo: | Malaria regions of the Amazon basin have been characterized by difficult access and non-compliance of the patients to treatment. In an attempt to assess the schizonticide efficacy of chloroquine in a single dose of 600 mg, the authors realized a double-blind, placebo-controlled trial in 132 outpatients with vivax malaria. Patients were distributed into two groups: group CPLA, given chloroquine 600 mg (single dose) on the first day of treatment, and two doses of placebo on second and third days. Group CHLO, given chloroquine 600 mg on first day and 450 mg on second and third day. Geometric means of the parasite density during the follow-up was similar in both groups. No differences were observed in the parasitological cure between the two groups (p = 0.442). There was clinical and parasitological efficacy in treatment of patients given a single-dose of chloroquine. This suggests that its restricted use could be indicated in remote areas of Brazilian Amazon Region, nevertheless the inadequate response of three patients indicates the need for further studies. |
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Pinto, Ana Yecê das NevesAzevedo, Carolina HeitmannSilva, Janaína Bezerra daSouza, José Maria de2019-01-21T14:09:17Z2019-01-21T14:09:17Z2003PINTO, Ana Yecê das Neves et al. Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian. Revista do Instituto de Medicina Tropical de São Paulo, v. 45, n. 6, p. 327-331, Nov.-Dec. 2003.0036-4665https://patua.iec.gov.br/handle/iec/356110.1590/S0036-46652003000600006Malaria regions of the Amazon basin have been characterized by difficult access and non-compliance of the patients to treatment. In an attempt to assess the schizonticide efficacy of chloroquine in a single dose of 600 mg, the authors realized a double-blind, placebo-controlled trial in 132 outpatients with vivax malaria. Patients were distributed into two groups: group CPLA, given chloroquine 600 mg (single dose) on the first day of treatment, and two doses of placebo on second and third days. Group CHLO, given chloroquine 600 mg on first day and 450 mg on second and third day. Geometric means of the parasite density during the follow-up was similar in both groups. No differences were observed in the parasitological cure between the two groups (p = 0.442). There was clinical and parasitological efficacy in treatment of patients given a single-dose of chloroquine. This suggests that its restricted use could be indicated in remote areas of Brazilian Amazon Region, nevertheless the inadequate response of three patients indicates the need for further studies.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Ensaios Clínicos em Malária. Belém, PA, Brasil.Centro de Ensino Superior do Pará. Belém, PA, Brasil.Centro de Ensino Superior do Pará. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Ensaios Clínicos em Malária. Belém, PA, Brasil.engUniversidade de São PauloAssessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilianCloroquina em dose simples no tratamento da malária por Plasmodium vivax na Amazônia brasileirainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMalária Vivax / terapiaCloroquina / uso terapêuticoPlasmodium vivaxinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAssessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian.pdfAssessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian.pdfapplication/pdf154564https://patua.iec.gov.br/bitstreams/05820fa7-e611-413d-9fba-81f5df721453/download114d30d6e8a607a69101b09be702434dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/3b6f89e6-3d93-4b36-ba0f-7978362ee09e/download11832eea31b16df8613079d742d61793MD52TEXTAssessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian.pdf.txtAssessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian.pdf.txtExtracted texttext/plain24236https://patua.iec.gov.br/bitstreams/f5a488d5-4e55-4894-b3cf-c011cec4a6b2/download2bf2be0461ab4b7dc3c0f674eb9899cbMD55THUMBNAILAssessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian.pdf.jpgAssessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian.pdf.jpgGenerated Thumbnailimage/jpeg5491https://patua.iec.gov.br/bitstreams/c2f98539-96b7-43e9-926b-331904c4a8cf/download9a3256b02774a87a9acf2d3e2d2ea630MD56iec/35612022-10-20 22:53:07.94oai:patua.iec.gov.br:iec/3561https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:53:07Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian |
dc.title.alternative.pt_BR.fl_str_mv |
Cloroquina em dose simples no tratamento da malária por Plasmodium vivax na Amazônia brasileira |
title |
Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian |
spellingShingle |
Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian Pinto, Ana Yecê das Neves Malária Vivax / terapia Cloroquina / uso terapêutico Plasmodium vivax |
title_short |
Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian |
title_full |
Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian |
title_fullStr |
Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian |
title_full_unstemmed |
Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian |
title_sort |
Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian |
author |
Pinto, Ana Yecê das Neves |
author_facet |
Pinto, Ana Yecê das Neves Azevedo, Carolina Heitmann Silva, Janaína Bezerra da Souza, José Maria de |
author_role |
author |
author2 |
Azevedo, Carolina Heitmann Silva, Janaína Bezerra da Souza, José Maria de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Pinto, Ana Yecê das Neves Azevedo, Carolina Heitmann Silva, Janaína Bezerra da Souza, José Maria de |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Malária Vivax / terapia Cloroquina / uso terapêutico Plasmodium vivax |
topic |
Malária Vivax / terapia Cloroquina / uso terapêutico Plasmodium vivax |
description |
Malaria regions of the Amazon basin have been characterized by difficult access and non-compliance of the patients to treatment. In an attempt to assess the schizonticide efficacy of chloroquine in a single dose of 600 mg, the authors realized a double-blind, placebo-controlled trial in 132 outpatients with vivax malaria. Patients were distributed into two groups: group CPLA, given chloroquine 600 mg (single dose) on the first day of treatment, and two doses of placebo on second and third days. Group CHLO, given chloroquine 600 mg on first day and 450 mg on second and third day. Geometric means of the parasite density during the follow-up was similar in both groups. No differences were observed in the parasitological cure between the two groups (p = 0.442). There was clinical and parasitological efficacy in treatment of patients given a single-dose of chloroquine. This suggests that its restricted use could be indicated in remote areas of Brazilian Amazon Region, nevertheless the inadequate response of three patients indicates the need for further studies. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2019-01-21T14:09:17Z |
dc.date.available.fl_str_mv |
2019-01-21T14:09:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PINTO, Ana Yecê das Neves et al. Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian. Revista do Instituto de Medicina Tropical de São Paulo, v. 45, n. 6, p. 327-331, Nov.-Dec. 2003. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3561 |
dc.identifier.issn.-.fl_str_mv |
0036-4665 |
dc.identifier.doi.-.fl_str_mv |
10.1590/S0036-46652003000600006 |
identifier_str_mv |
PINTO, Ana Yecê das Neves et al. Assessment of choloroquine single dose treatment of malaria due to Plasmodium vivax in brazilian. Revista do Instituto de Medicina Tropical de São Paulo, v. 45, n. 6, p. 327-331, Nov.-Dec. 2003. 0036-4665 10.1590/S0036-46652003000600006 |
url |
https://patua.iec.gov.br/handle/iec/3561 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
institution |
IEC |
reponame_str |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
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