Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3240 |
Resumo: | A total of 220 patients with arthropathy were selected in Belem, Para between January 1994 and December 2000, and screened for the presence of human parvovirus B19 IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). A subgroup (n = 132) of patients with high levels of antibodies (either IgM+/IgG+ or IgM-/IgG+) were examined for the presence of DNA by polymerase chain reaction/nested PCR. Recent/active infection (detection of IgM and/or IgG-specific antibodies and presence of viral DNA) was identified in 47.7 per cent of the 132 individuals with arthropathy. In our study, women were significantly more affected (59.7 per cent) than men (35.4 per cent) (P = 0.0006). The age group of 11-20 years (84.6 per cent), among female patients, and 21-30 years (42.1 per cent), among male, were those with the highest incidence rates. The analysis of the temporal distribution of B19-associated arthropaties showed a cyclic pattern, with peak incidence rates occuring at 3-5 year intervals. Significant diference (P = 0.01) was observed when comparing both the highest (39.0 per cent) and the lowest (11.0 per cent) seropositivity rates for the years of 1995 and 2000, respectively. The interfalangial joints of hands and feet were mostly affected, with 50.0 per cent and 48.0 per cent of cases among both women and men, respectively. In a smaller proportion, other joints such as those of knee, ankle, pulse and shoulder were affected. As for the duration, symptoms lasted 1 to 5 days in 54.0 per cent of the individuals, whereas in 46.0 per cent of them the disease lasted 6-10 days, if considered the subgroup (n = 63) of patients with recent/active infection by parvovirus B19. In our study, joint clinical manifestations occurred symmetrically. Our results indicate that B19 may be an important agent of arthropathies in our region, and this underscores the need for specific laboratory diagnosis when treating patients suffering from acute arthropathy, mainly pregnant women. |
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Freitas, Ronaldo Barros deMonteiro, Talita Antônia FurtadoSilva Filho, Manoel Gomes daLinhares, Alexandre da Costa2018-07-16T17:45:50Z2018-07-16T17:45:50Z2002FREITAS, Ronaldo Barros de et al. Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 1, p. 17-22, Jan.-Feb. 2002.0036-4665https://patua.iec.gov.br/handle/iec/3240A total of 220 patients with arthropathy were selected in Belem, Para between January 1994 and December 2000, and screened for the presence of human parvovirus B19 IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). A subgroup (n = 132) of patients with high levels of antibodies (either IgM+/IgG+ or IgM-/IgG+) were examined for the presence of DNA by polymerase chain reaction/nested PCR. Recent/active infection (detection of IgM and/or IgG-specific antibodies and presence of viral DNA) was identified in 47.7 per cent of the 132 individuals with arthropathy. In our study, women were significantly more affected (59.7 per cent) than men (35.4 per cent) (P = 0.0006). The age group of 11-20 years (84.6 per cent), among female patients, and 21-30 years (42.1 per cent), among male, were those with the highest incidence rates. The analysis of the temporal distribution of B19-associated arthropaties showed a cyclic pattern, with peak incidence rates occuring at 3-5 year intervals. Significant diference (P = 0.01) was observed when comparing both the highest (39.0 per cent) and the lowest (11.0 per cent) seropositivity rates for the years of 1995 and 2000, respectively. The interfalangial joints of hands and feet were mostly affected, with 50.0 per cent and 48.0 per cent of cases among both women and men, respectively. In a smaller proportion, other joints such as those of knee, ankle, pulse and shoulder were affected. As for the duration, symptoms lasted 1 to 5 days in 54.0 per cent of the individuals, whereas in 46.0 per cent of them the disease lasted 6-10 days, if considered the subgroup (n = 63) of patients with recent/active infection by parvovirus B19. In our study, joint clinical manifestations occurred symmetrically. Our results indicate that B19 may be an important agent of arthropathies in our region, and this underscores the need for specific laboratory diagnosis when treating patients suffering from acute arthropathy, mainly pregnant women.Um total de 220 indivíduos portadores de artropatias foi selecionado em Belém, Pará, entre janeiro de 1994 e dezembro de 2000 e, posteriormente, examinado com o propósito de se detectarem anticorpos IgM e IgG para o parvovírus B19, utilizando-se a técnica imunoenzimática (ELISA). Um subgrupo (n = 132) de indivíduos com amostras de soro apresentando altos níveis de anticorpos (IgM+/IgG+ e IgM-/IgG+) foi usado para detecção de DNA do B19 através da reação em cadeia da polimerase (PCR) e do ônestedö PCR. Infecção recente/ativa (detecção de IgM e/ou IgG mais a presença de DNA viral) foi diagnosticada em 47,7 por cento dos 132 indivíduos apresentando comprometimento das articulações. O sexo feminino foi mais afetado (59,7 por cento) que o masculino (35,4 por cento), com diferença estatisticamente significativa (P = 0,0006). Os grupos etários mais atingidos foram os de 11-20 anos (84,6 por cento), no sexo feminino, e 21-30 anos (42,1 por cento), no masculino. A análise da distribuição temporal mostrou um padrão cíclico, com períodos de maior e menor atividade viral que variam de 3 a 5 anos. Diferença estatisticamente significativa (P = 0,01) foi observada quando comparadas as freqüências de positividade mais alta (39,0 por cento) e mais baixa (11,0 por cento) para os anos de 1995 e 2000, respectivamente. As articulações mais atingidas foram, em ordem de freqüência, as interfalangianas de mãos e pés, com 50,0 por cento e 48,0 por cento para o sexo feminino e masculino, respectivamente. Em menor proporção outras articulações tais como as do joelho, tornozelo, pulso e ombro foram afetadas. Quanto à duração das manifestações articulares, 54,0 por cento evoluíram por 1-5 dias, e 46,0 por cento ao longo de 6-10 dias, considerando o subgrupo (n = 63) de indivíduos com infecção recente/ativa para o B19 em ambos os sexos. Em nosso estudo, o comprometimento das articulações apresentou caráter simétrico. Os resultados encontrados demonstraram o freqüente acometimento articular associado às infecções recentes/ativas por parvovírus B19, ressaltando a necessidade do diagnóstico laboratorial dessa virose, principalmente entre gestantes.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Universidade de São PauloAssociation between human parvovirus B19 and arthropathy in Belém, Pará, North BrazilAssociação entre parvovírus B19 e artropatias em Belém, Pará, norte do Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleParvovirus B19 HumanoArtropatias / complicaçõesinfo:eu-repo/semantics/openAccessengreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAssociation between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil.pdfAssociation between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil.pdfapplication/pdf149271https://patua.iec.gov.br/bitstreams/1ca65eec-e6c7-4ac7-8388-43e921c37e56/download75a3c59084fbaddcadb7934c169d8329MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/5775ead9-4e0f-4c8d-a146-3ee4f0d12d5b/download52f1732ea66fbd1123abe39f5373b797MD52TEXTAssociation between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil.pdf.txtAssociation between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil.pdf.txtExtracted texttext/plain30605https://patua.iec.gov.br/bitstreams/d4d3496c-4c5d-45a7-97e3-069e7500d292/download7f13ce430d0a3fece2d0b3986756f6e2MD55THUMBNAILAssociation between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil.pdf.jpgAssociation between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5924https://patua.iec.gov.br/bitstreams/ab8c9d3c-48a2-440a-9c5d-8a2ee62c6c94/downloadfca1fbc847a879ed19336e12467a7ff9MD56iec/32402022-10-20 22:41:03.151oai:patua.iec.gov.br:iec/3240https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:41:03Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Associação entre parvovírus B19 e artropatias em Belém, Pará, norte do Brasil |
title |
Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil |
spellingShingle |
Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil Freitas, Ronaldo Barros de Parvovirus B19 Humano Artropatias / complicações |
title_short |
Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil |
title_full |
Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil |
title_fullStr |
Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil |
title_full_unstemmed |
Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil |
title_sort |
Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil |
author |
Freitas, Ronaldo Barros de |
author_facet |
Freitas, Ronaldo Barros de Monteiro, Talita Antônia Furtado Silva Filho, Manoel Gomes da Linhares, Alexandre da Costa |
author_role |
author |
author2 |
Monteiro, Talita Antônia Furtado Silva Filho, Manoel Gomes da Linhares, Alexandre da Costa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Freitas, Ronaldo Barros de Monteiro, Talita Antônia Furtado Silva Filho, Manoel Gomes da Linhares, Alexandre da Costa |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Parvovirus B19 Humano Artropatias / complicações |
topic |
Parvovirus B19 Humano Artropatias / complicações |
description |
A total of 220 patients with arthropathy were selected in Belem, Para between January 1994 and December 2000, and screened for the presence of human parvovirus B19 IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). A subgroup (n = 132) of patients with high levels of antibodies (either IgM+/IgG+ or IgM-/IgG+) were examined for the presence of DNA by polymerase chain reaction/nested PCR. Recent/active infection (detection of IgM and/or IgG-specific antibodies and presence of viral DNA) was identified in 47.7 per cent of the 132 individuals with arthropathy. In our study, women were significantly more affected (59.7 per cent) than men (35.4 per cent) (P = 0.0006). The age group of 11-20 years (84.6 per cent), among female patients, and 21-30 years (42.1 per cent), among male, were those with the highest incidence rates. The analysis of the temporal distribution of B19-associated arthropaties showed a cyclic pattern, with peak incidence rates occuring at 3-5 year intervals. Significant diference (P = 0.01) was observed when comparing both the highest (39.0 per cent) and the lowest (11.0 per cent) seropositivity rates for the years of 1995 and 2000, respectively. The interfalangial joints of hands and feet were mostly affected, with 50.0 per cent and 48.0 per cent of cases among both women and men, respectively. In a smaller proportion, other joints such as those of knee, ankle, pulse and shoulder were affected. As for the duration, symptoms lasted 1 to 5 days in 54.0 per cent of the individuals, whereas in 46.0 per cent of them the disease lasted 6-10 days, if considered the subgroup (n = 63) of patients with recent/active infection by parvovirus B19. In our study, joint clinical manifestations occurred symmetrically. Our results indicate that B19 may be an important agent of arthropathies in our region, and this underscores the need for specific laboratory diagnosis when treating patients suffering from acute arthropathy, mainly pregnant women. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002 |
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2018-07-16T17:45:50Z |
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2018-07-16T17:45:50Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
FREITAS, Ronaldo Barros de et al. Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 1, p. 17-22, Jan.-Feb. 2002. |
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https://patua.iec.gov.br/handle/iec/3240 |
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0036-4665 |
identifier_str_mv |
FREITAS, Ronaldo Barros de et al. Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 1, p. 17-22, Jan.-Feb. 2002. 0036-4665 |
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https://patua.iec.gov.br/handle/iec/3240 |
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eng |
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Universidade de São Paulo |
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Universidade de São Paulo |
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