Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4053 |
Resumo: | We described the HIV-1 subtypes and the frequency of resistance mutations in HIV-1 integrase region among antiretroviral-naive patients with HIV/AIDS from Belém, Pará, Amazon region of Brazil. The partial integrase gene sequence of 59 antiretroviral-naive HIV-1 infected patients was amplified and sequenced. Genotypic analyses revealed the absence of major resistance-associated mutations to integrase but minor polymorphic mutations were present in 44.1% of patients and M50I polymorphism was the more prevalent. |
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Torres, Maria K. SAvelino, Maria E. SIrias, Susan FBarbosa, Mike SPereira, Danilo L. ALima, Ana B. FLemos, Poliana da SilvaLima, Clayton Pereira Silva deOliveira, Renato R. MFrânces, Regiane S. KVianez Júnior, João Lídio da Silva GonçalvesMachado, Luiz Fernando Almeida2020-02-20T17:41:06Z2020-02-20T17:41:06Z2020TORRES, Maria K. S. et al. Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil. AIDS Research and Human Retroviruses, v. 36, n. 2, p. 97-98, Feb. 2020.1931-8405https://patua.iec.gov.br/handle/iec/405310.1089/AID.2019.019We described the HIV-1 subtypes and the frequency of resistance mutations in HIV-1 integrase region among antiretroviral-naive patients with HIV/AIDS from Belém, Pará, Amazon region of Brazil. The partial integrase gene sequence of 59 antiretroviral-naive HIV-1 infected patients was amplified and sequenced. Genotypic analyses revealed the absence of major resistance-associated mutations to integrase but minor polymorphic mutations were present in 44.1% of patients and M50I polymorphism was the more prevalent.Universidade Federal do Pará. Instituto de Ciências Biológicas. Programa de Pós-graduação em Biologia de Agentes Infecciosos e Parasitários. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Programa de Pós-graduação em Biologia de Agentes Infecciosos e Parasitários. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Programa de Pós-graduação em Biologia de Agentes Infecciosos e Parasitários. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Programa de Pós-graduação em Biologia de Agentes Infecciosos e Parasitários. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Programa de Pós-graduação em Biologia de Agentes Infecciosos e Parasitários. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Programa de Pós-graduação em Biologia de Agentes Infecciosos e Parasitários. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Bioinformática. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Bioinformática. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Bioinformática. Ananindeua, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Laboratório de Bioinformática e Computação de Alto Desempenho. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Programa de Pós-graduação em Biologia de Agentes Infecciosos e Parasitários. Belém, PA, Brazil / Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Virologia. Belém, PA, Brazil.engMary Ann LiebertLow prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHIV-1 / patogenicidadeTerapia Antirretroviral de Alta AtividadeInfecções por HIVSíndrome de Imunodeficiência AdquiridaIntegrase de HIVIntegrasesinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALLow prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil.pdfLow prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/5c87a434-bf38-4e75-98a8-249e2b71c0fe/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil |
title |
Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil |
spellingShingle |
Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil Torres, Maria K. S HIV-1 / patogenicidade Terapia Antirretroviral de Alta Atividade Infecções por HIV Síndrome de Imunodeficiência Adquirida Integrase de HIV Integrases |
title_short |
Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil |
title_full |
Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil |
title_fullStr |
Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil |
title_full_unstemmed |
Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil |
title_sort |
Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil |
author |
Torres, Maria K. S |
author_facet |
Torres, Maria K. S Avelino, Maria E. S Irias, Susan F Barbosa, Mike S Pereira, Danilo L. A Lima, Ana B. F Lemos, Poliana da Silva Lima, Clayton Pereira Silva de Oliveira, Renato R. M Frânces, Regiane S. K Vianez Júnior, João Lídio da Silva Gonçalves Machado, Luiz Fernando Almeida |
author_role |
author |
author2 |
Avelino, Maria E. S Irias, Susan F Barbosa, Mike S Pereira, Danilo L. A Lima, Ana B. F Lemos, Poliana da Silva Lima, Clayton Pereira Silva de Oliveira, Renato R. M Frânces, Regiane S. K Vianez Júnior, João Lídio da Silva Gonçalves Machado, Luiz Fernando Almeida |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Torres, Maria K. S Avelino, Maria E. S Irias, Susan F Barbosa, Mike S Pereira, Danilo L. A Lima, Ana B. F Lemos, Poliana da Silva Lima, Clayton Pereira Silva de Oliveira, Renato R. M Frânces, Regiane S. K Vianez Júnior, João Lídio da Silva Gonçalves Machado, Luiz Fernando Almeida |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
HIV-1 / patogenicidade Terapia Antirretroviral de Alta Atividade Infecções por HIV Síndrome de Imunodeficiência Adquirida Integrase de HIV Integrases |
topic |
HIV-1 / patogenicidade Terapia Antirretroviral de Alta Atividade Infecções por HIV Síndrome de Imunodeficiência Adquirida Integrase de HIV Integrases |
description |
We described the HIV-1 subtypes and the frequency of resistance mutations in HIV-1 integrase region among antiretroviral-naive patients with HIV/AIDS from Belém, Pará, Amazon region of Brazil. The partial integrase gene sequence of 59 antiretroviral-naive HIV-1 infected patients was amplified and sequenced. Genotypic analyses revealed the absence of major resistance-associated mutations to integrase but minor polymorphic mutations were present in 44.1% of patients and M50I polymorphism was the more prevalent. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-02-20T17:41:06Z |
dc.date.available.fl_str_mv |
2020-02-20T17:41:06Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
TORRES, Maria K. S. et al. Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil. AIDS Research and Human Retroviruses, v. 36, n. 2, p. 97-98, Feb. 2020. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4053 |
dc.identifier.issn.-.fl_str_mv |
1931-8405 |
dc.identifier.doi.-.fl_str_mv |
10.1089/AID.2019.019 |
identifier_str_mv |
TORRES, Maria K. S. et al. Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil. AIDS Research and Human Retroviruses, v. 36, n. 2, p. 97-98, Feb. 2020. 1931-8405 10.1089/AID.2019.019 |
url |
https://patua.iec.gov.br/handle/iec/4053 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.publisher.none.fl_str_mv |
Mary Ann Liebert |
publisher.none.fl_str_mv |
Mary Ann Liebert |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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