Anti-promastigote activity of the amazon plants

Detalhes bibliográficos
Autor(a) principal: Silva-Silva, João Victor
Data de Publicação: 2017
Outros Autores: Monteiro, R. C. S., Brígido, Helliton Patrick Cordovil, Vale, Valdicley Vieira, Silvestre, J. V., Silva, N. C. S., Silveira, Fernando Tobias, Marinho, A. M. R., Dolabela, Maria Fâni
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/3692
Resumo: This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was evaluated through the cell viability assessment method (MTT). The ethanol extract, fractions, and isolated substance from Himatanthus articulatus and Parahancornia fasciculata were inactive in promastigote of L. amazonensis, as the ethanol extract of Physalis angulata. The hexane fractions from different parts of Montrichardia linifera showed anti-promastigote activity probably due to the presence of steroids and terpenes. All species in studies were inactive, except of M. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required.
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spelling Silva-Silva, João VictorMonteiro, R. C. S.Brígido, Helliton Patrick CordovilVale, Valdicley VieiraSilvestre, J. V.Silva, N. C. S.Silveira, Fernando TobiasMarinho, A. M. R.Dolabela, Maria Fâni2019-05-17T11:18:17Z2019-05-17T11:18:17Z2017SILVA-SILVA, João Victor et al. Anti-promastigote activity of the amazon plants. Journal of Pharmacy and Pharmacology, v. 5, n. 9, p. 654-660, Sept. 2017.2328-2150https://patua.iec.gov.br/handle/iec/369210.17265/2328-2150/2017.09.007This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was evaluated through the cell viability assessment method (MTT). The ethanol extract, fractions, and isolated substance from Himatanthus articulatus and Parahancornia fasciculata were inactive in promastigote of L. amazonensis, as the ethanol extract of Physalis angulata. The hexane fractions from different parts of Montrichardia linifera showed anti-promastigote activity probably due to the presence of steroids and terpenes. All species in studies were inactive, except of M. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required.Universidade Federal do Pará. Programa de Pós-Graduação em Ciências Farmacêuticas. Belém, PA, Brasil.Universidade Federal do Pará. Programa de Pós-Graduação em Ciências Farmacêuticas. Belém, PA, Brasil.Universidade Federal do Pará. Programa de Pós-Graduação em Ciências Farmacêuticas. Belém, PA, Brasil.Universidade Federal do Pará. Programa de Pós-Graduação em Inovação Farmacêutica. Belém, PA, Brasil.Universidade Federal do Pará. Faculdade de Ciências Farmacêuticas. Belém, PA, Brasil.Universidade Federal do Pará. Faculdade de Ciências Farmacêuticas. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Pará. Faculdade de Química. Belém, PA, Brasil.Universidade Federal do Pará. Programa de Pós-Graduação em Ciências Farmacêuticas. Belém, PA, Brasil / Universidade Federal do Pará. Programa de Pós-Graduação em Inovação Farmacêutica. 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dc.title.pt_BR.fl_str_mv Anti-promastigote activity of the amazon plants
title Anti-promastigote activity of the amazon plants
spellingShingle Anti-promastigote activity of the amazon plants
Silva-Silva, João Victor
Fitoterapia / métodos
Plantas Medicinais / química
Extratos Vegetais / química
Leishmania / efeitos dos fármacos
Himatanthus articulatus
Fasciculata parahancornia
Montrichardia linifera
Physalis angulata
title_short Anti-promastigote activity of the amazon plants
title_full Anti-promastigote activity of the amazon plants
title_fullStr Anti-promastigote activity of the amazon plants
title_full_unstemmed Anti-promastigote activity of the amazon plants
title_sort Anti-promastigote activity of the amazon plants
author Silva-Silva, João Victor
author_facet Silva-Silva, João Victor
Monteiro, R. C. S.
Brígido, Helliton Patrick Cordovil
Vale, Valdicley Vieira
Silvestre, J. V.
Silva, N. C. S.
Silveira, Fernando Tobias
Marinho, A. M. R.
Dolabela, Maria Fâni
author_role author
author2 Monteiro, R. C. S.
Brígido, Helliton Patrick Cordovil
Vale, Valdicley Vieira
Silvestre, J. V.
Silva, N. C. S.
Silveira, Fernando Tobias
Marinho, A. M. R.
Dolabela, Maria Fâni
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva-Silva, João Victor
Monteiro, R. C. S.
Brígido, Helliton Patrick Cordovil
Vale, Valdicley Vieira
Silvestre, J. V.
Silva, N. C. S.
Silveira, Fernando Tobias
Marinho, A. M. R.
Dolabela, Maria Fâni
dc.subject.decsPrimary.pt_BR.fl_str_mv Fitoterapia / métodos
Plantas Medicinais / química
Extratos Vegetais / química
Leishmania / efeitos dos fármacos
Himatanthus articulatus
Fasciculata parahancornia
Montrichardia linifera
Physalis angulata
topic Fitoterapia / métodos
Plantas Medicinais / química
Extratos Vegetais / química
Leishmania / efeitos dos fármacos
Himatanthus articulatus
Fasciculata parahancornia
Montrichardia linifera
Physalis angulata
description This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was evaluated through the cell viability assessment method (MTT). The ethanol extract, fractions, and isolated substance from Himatanthus articulatus and Parahancornia fasciculata were inactive in promastigote of L. amazonensis, as the ethanol extract of Physalis angulata. The hexane fractions from different parts of Montrichardia linifera showed anti-promastigote activity probably due to the presence of steroids and terpenes. All species in studies were inactive, except of M. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-05-17T11:18:17Z
dc.date.available.fl_str_mv 2019-05-17T11:18:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA-SILVA, João Victor et al. Anti-promastigote activity of the amazon plants. Journal of Pharmacy and Pharmacology, v. 5, n. 9, p. 654-660, Sept. 2017.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/3692
dc.identifier.issn.-.fl_str_mv 2328-2150
dc.identifier.doi.-.fl_str_mv 10.17265/2328-2150/2017.09.007
identifier_str_mv SILVA-SILVA, João Victor et al. Anti-promastigote activity of the amazon plants. Journal of Pharmacy and Pharmacology, v. 5, n. 9, p. 654-660, Sept. 2017.
2328-2150
10.17265/2328-2150/2017.09.007
url https://patua.iec.gov.br/handle/iec/3692
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv David Publishing
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dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
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instacron:IEC
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