Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3244 |
Resumo: | To determine the efficacy of a reassortant rhesus-human tetravalent rotavirus vaccine (RRV-TV) (4 x 10(4) pfu/dose) against P and G rotavirus genotypes, 90 positive samples were tested using reverse transcription-polymerase chain reaction. The efficacy of the RRV-TV vaccine against P[8] and G1 individually or in binary combination P[8], G1 was 72 per cent (p 0.005) 61 per cent (p 0.013), and 70 per cent (p 0.009), respectively, only for the first year of follow-up. In the second year, as well as after 2 years of follow-up, no efficacy was observed to these genotypes. These data indicate that further studies with rotavirus vaccines should focus on the molecular characterization of rotaviruses genotypes, in order to see whether or not cross-protection among different G and P genotypes may occur as a result of common bearing of VP4 specificities. |
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Mascarenhas, Joana D'Arc PereiraLeite, José Paulo GGabbay, Yvone BenchimolAlmeida, M. LLinhares, Alexandre da Costa2018-07-16T19:12:35Z2018-07-16T19:12:35Z2002MASCARENHAS, Joana D’Arc Pereira et al. Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes. Journal of Tropical Pediatrics, v. 48, n. 5, p. 300-302, Oct. 2002.0142-6338https://patua.iec.gov.br/handle/iec/3244To determine the efficacy of a reassortant rhesus-human tetravalent rotavirus vaccine (RRV-TV) (4 x 10(4) pfu/dose) against P and G rotavirus genotypes, 90 positive samples were tested using reverse transcription-polymerase chain reaction. The efficacy of the RRV-TV vaccine against P[8] and G1 individually or in binary combination P[8], G1 was 72 per cent (p 0.005) 61 per cent (p 0.013), and 70 per cent (p 0.009), respectively, only for the first year of follow-up. In the second year, as well as after 2 years of follow-up, no efficacy was observed to these genotypes. These data indicate that further studies with rotavirus vaccines should focus on the molecular characterization of rotaviruses genotypes, in order to see whether or not cross-protection among different G and P genotypes may occur as a result of common bearing of VP4 specificities.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Instituto Oswaldo Cruz. Departamento de Virologia. Rio Janeiro, RJ, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Programa Institucional de Bolsas de Iniciação Científica. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.engOxford University PressTetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVacinas contra Rotavirus / análiseVacinas contra Rotavirus / uso terapêuticoResultado do Tratamentoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALTetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes.pdfTetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes.pdfapplication/pdf51822https://patua.iec.gov.br/bitstreams/1c50c569-100e-446d-b88b-088181a4bddc/download8761b48bde8e07823e19101fc72e0fb0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/2c4c0413-11ed-4774-a6cf-6f5c85bd8210/download52f1732ea66fbd1123abe39f5373b797MD52TEXTTetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes.pdf.txtTetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes.pdf.txtExtracted texttext/plain11771https://patua.iec.gov.br/bitstreams/b683ed70-bf4c-4c6d-970a-52e70c038c1b/downloadb92bb49da145fcc302f3e7164ed25bbbMD55THUMBNAILTetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes.pdf.jpgTetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes.pdf.jpgGenerated Thumbnailimage/jpeg6404https://patua.iec.gov.br/bitstreams/611a113a-b93a-4e0a-b9d9-af931bee5497/downloadee23c8af0ae21ff72937ac42ac68482fMD56iec/32442022-10-20 23:22:30.99oai:patua.iec.gov.br:iec/3244https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T23:22:30Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes |
title |
Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes |
spellingShingle |
Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes Mascarenhas, Joana D'Arc Pereira Vacinas contra Rotavirus / análise Vacinas contra Rotavirus / uso terapêutico Resultado do Tratamento |
title_short |
Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes |
title_full |
Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes |
title_fullStr |
Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes |
title_full_unstemmed |
Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes |
title_sort |
Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes |
author |
Mascarenhas, Joana D'Arc Pereira |
author_facet |
Mascarenhas, Joana D'Arc Pereira Leite, José Paulo G Gabbay, Yvone Benchimol Almeida, M. L Linhares, Alexandre da Costa |
author_role |
author |
author2 |
Leite, José Paulo G Gabbay, Yvone Benchimol Almeida, M. L Linhares, Alexandre da Costa |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Mascarenhas, Joana D'Arc Pereira Leite, José Paulo G Gabbay, Yvone Benchimol Almeida, M. L Linhares, Alexandre da Costa |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Vacinas contra Rotavirus / análise Vacinas contra Rotavirus / uso terapêutico Resultado do Tratamento |
topic |
Vacinas contra Rotavirus / análise Vacinas contra Rotavirus / uso terapêutico Resultado do Tratamento |
description |
To determine the efficacy of a reassortant rhesus-human tetravalent rotavirus vaccine (RRV-TV) (4 x 10(4) pfu/dose) against P and G rotavirus genotypes, 90 positive samples were tested using reverse transcription-polymerase chain reaction. The efficacy of the RRV-TV vaccine against P[8] and G1 individually or in binary combination P[8], G1 was 72 per cent (p 0.005) 61 per cent (p 0.013), and 70 per cent (p 0.009), respectively, only for the first year of follow-up. In the second year, as well as after 2 years of follow-up, no efficacy was observed to these genotypes. These data indicate that further studies with rotavirus vaccines should focus on the molecular characterization of rotaviruses genotypes, in order to see whether or not cross-protection among different G and P genotypes may occur as a result of common bearing of VP4 specificities. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002 |
dc.date.accessioned.fl_str_mv |
2018-07-16T19:12:35Z |
dc.date.available.fl_str_mv |
2018-07-16T19:12:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MASCARENHAS, Joana D’Arc Pereira et al. Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes. Journal of Tropical Pediatrics, v. 48, n. 5, p. 300-302, Oct. 2002. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3244 |
dc.identifier.issn.-.fl_str_mv |
0142-6338 |
identifier_str_mv |
MASCARENHAS, Joana D’Arc Pereira et al. Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes. Journal of Tropical Pediatrics, v. 48, n. 5, p. 300-302, Oct. 2002. 0142-6338 |
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https://patua.iec.gov.br/handle/iec/3244 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Oxford University Press |
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Oxford University Press |
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