Organic effects of associating paclitaxel with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella

• Autor(a) principal: Feio, Danielle Cristina Azevedo
• Data de Publicação: 2017
• Outros Autores: Oliveira, Nayara Cristina Lima de, Pereira, Edmundo Luis Rodrigues, Morikawa, Aleksandra Tiemi, Muniz, José Augusto Pereira Carneiro, Montenegro, Raquel Carvalho, Alves, Ana Paula Negreiros Nunes, Lima, Patricia Danielle Lima de, Maranhão, Raul Cavalcante, Burbano, Rommel Rodríguez
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/2877
• topic: Cebus / anatomia & histologia; Cebus / sangue; Paclitaxel / administração & dosagem; Paclitaxel / efeitos adversos; Paclitaxel / farmacocinética; Paclitaxel / toxicidade; Paclitaxel / uso terapêutico; Emulsões Gordurosas Intravenosas / administração & dosagem; Emulsões Gordurosas Intravenosas / efeitos adversos; Emulsões Gordurosas Intravenosas / toxicidade; Emulsões Gordurosas Intravenosas / farmacocinética; Emulsões Gordurosas Intravenosas / uso terapêutico; Quimioterapia Combinada / efeitos adversos; Avaliação Pré-Clínica de Medicamentos / veterinária; Análise Química do Sangue / veterinária; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos; Análise de Variância; Nanopartículas; Lipídeos

Lipid-based nanoparticle systems have been used as vehicles for chemotherapeutic agents in experimental cancer treatments. Those systems have generally been credited with attenuating the severe toxicity of chemotherapeutic agents. This study aimed to investigate the effects of associating paclitaxel (PTX) with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella, documenting the toxicity as measured by serum biochemistry, which is a detailed analysis of blood and tissue. Eighteen C. apella were studied: three animals were treated with cholesterol-rich nanoemulsion (LDE) only, without PTX, administered intravenously every 3 weeks, during six treatment cycles; six animals were treated with PTX associated with LDE at the same administration scheme, three with lower (175 mg/m2 ) and three with higher (250 mg/m2 ) PTX doses; and six animals were treated with commercial PTX, three with the lower and three with the higher doses. In the LDE-PTX group, no clinical toxicity appeared, and the weight–food consumption curve was similar to that of the controls. Two animals treated with commercial PTX presented weight loss, nausea and vomiting, diarrhea, skin flaking, 70% loss of body hair, and decreased physical activity. The use of LDE as a carrier at both lower and higher doses reduced the toxicity of the drug in this species, which is closely related to human subjects. This was observed not only by clinical, biochemical, and hematological profiles but also by the histopathological analysis. The results of this study support the assumption that lipid-based nanoparticle systems used as drug carriers can serve as valuable tools to decrease the toxicity and increase the safety of chemotherapeutic agents.