Mechanisms of human cytomegalovirus infection with a focus on epidermal growth factor receptor interactions

• Autor(a) principal: Falcão, Aline Semblano Carreira
• Data de Publicação: 2017
• Outros Autores: Vasconcelos, Pedro Fernando da Costa, Silva, Dorotéa de Fátima Lobato da, Pinheiro, João de Jesus Viana, Falcão, Luiz Fábio Magno, Quaresma, Juarez Antônio Simões
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: http://patua.iec.gov.br//handle/iec/2908
• topic: Citomegalovirus / patogenicidade; Infecções por Citomegalovirus; Fator de Crescimento Epidérmico; Infecções por Vírus de DNA; Receptores de Superfície Celular; Transdução de Sinais

Human cytomegalovirus (HCMV) is a widespread opportunistic herpesvirus that causes severe diseases in immunocompromised individuals. It has a high prevalence worldwide that is linked with socioeconomic factors. Similar to other herpesviruses, HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. HCMV infects a broad range of cell types. This broad tropism suggests that it may use multiple receptors for host cell entry. The identification of receptors used by HCMV is essential for understanding viral pathogenesis, because these receptors mediate the early events necessary for infection. Many cell surface components have been identified as virus receptors, such as epidermal growth factor receptor (EGFR), which is characterized by tyrosine kinase activity and plays a crucial role in the control of key cellular transduction pathways. EGFR is essential for HCMV binding, signaling, and host cell entry. This review focuses on HCMV infection via EGFR on different cell types and its implications for the cellular environment, viral persistence, and infection.