Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/1058 |
Resumo: | The role of the insulin-like growth factor I (IGF-I) system and nutritional status was studied in 241 children from a Brazilian area endemic for visceral leishmaniasis (VL). Thirtynine children had the active form, 20 were oligosymptomatic, 38 were asymptomatic and 144 were not infected. Serum concentrations of growth hormone (GH), total and free IGF-I and IGF binding-protein 3 (IGFBP3) were measured by radioimmunoassay. Nutritional status was evaluated by anthropometric indicators and biochemical measurements. Total and free IGF-I and IGFBP3 were significantly reduced in the active form. Z scores for total and free IGF-I and for IGFBP3 were found to be significantly lower for active VL and oligosymptomatic individuals than for asymptomatic individuals, but never reached values ≤2 SD. Median values of weight-for-age Z and height-for-age Z (HAZ) scores and albumin concentration were significantly different in the active VL group compared with the other groups. Multiple discriminant analysis selected albumin and HAZ score as predictors of active and oligosymptomatic VL. The lack of correlation between auxological data and serum concentrations of the GH/IGF axis components suggested that the primary cause of retarded growth in children with active VL is not dependent on IGF-I or IGFBP3, but rather on VL intrinsic factors that might secondarily involve the GH/IGF axis. |
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Gomes, Claudia Maria de CastroGianella Neto, DanielGama, Monica Elinor AlvesPereira, Julio Cesar RCampos, Marliane BatistaCorbett, Carlos Eduardo Pereira2016-01-26T11:43:20Z2016-01-26T11:43:20Z2007GOMES, Claudia Maria de Castro et al. Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis. Transactions of the Royal Society of The Tropical Medicine and Hygiene, v. 101, n. 7, p. 660-667, 20070035-9203https://patua.iec.gov.br/handle/iec/105810.1016/j.trstmh.2007.02.017The role of the insulin-like growth factor I (IGF-I) system and nutritional status was studied in 241 children from a Brazilian area endemic for visceral leishmaniasis (VL). Thirtynine children had the active form, 20 were oligosymptomatic, 38 were asymptomatic and 144 were not infected. Serum concentrations of growth hormone (GH), total and free IGF-I and IGF binding-protein 3 (IGFBP3) were measured by radioimmunoassay. Nutritional status was evaluated by anthropometric indicators and biochemical measurements. Total and free IGF-I and IGFBP3 were significantly reduced in the active form. Z scores for total and free IGF-I and for IGFBP3 were found to be significantly lower for active VL and oligosymptomatic individuals than for asymptomatic individuals, but never reached values ≤2 SD. Median values of weight-for-age Z and height-for-age Z (HAZ) scores and albumin concentration were significantly different in the active VL group compared with the other groups. Multiple discriminant analysis selected albumin and HAZ score as predictors of active and oligosymptomatic VL. The lack of correlation between auxological data and serum concentrations of the GH/IGF axis components suggested that the primary cause of retarded growth in children with active VL is not dependent on IGF-I or IGFBP3, but rather on VL intrinsic factors that might secondarily involve the GH/IGF axis.University of São Paulo Medical School. Department of Pathology. São Paulo, SP, Brazil.University of São Paulo Medical School. Division of Endocrinology. São Paulo, SP, Brazil.Federal Universty of Maranhão. Department of Pediatrics. São Luis, MA, Brazil.University of São Paulo. Department of Epidemiology. São Paulo, SP, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.University of São Paulo Medical School. Department of Pathology. 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dc.title.pt_BR.fl_str_mv |
Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis |
title |
Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis |
spellingShingle |
Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis Gomes, Claudia Maria de Castro Fator de Crescimento Insulin-Like I Leishmaniose Visceral Transtornos da Nutrição Infantil |
title_short |
Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis |
title_full |
Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis |
title_fullStr |
Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis |
title_full_unstemmed |
Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis |
title_sort |
Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis |
author |
Gomes, Claudia Maria de Castro |
author_facet |
Gomes, Claudia Maria de Castro Gianella Neto, Daniel Gama, Monica Elinor Alves Pereira, Julio Cesar R Campos, Marliane Batista Corbett, Carlos Eduardo Pereira |
author_role |
author |
author2 |
Gianella Neto, Daniel Gama, Monica Elinor Alves Pereira, Julio Cesar R Campos, Marliane Batista Corbett, Carlos Eduardo Pereira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Claudia Maria de Castro Gianella Neto, Daniel Gama, Monica Elinor Alves Pereira, Julio Cesar R Campos, Marliane Batista Corbett, Carlos Eduardo Pereira |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Fator de Crescimento Insulin-Like I Leishmaniose Visceral Transtornos da Nutrição Infantil |
topic |
Fator de Crescimento Insulin-Like I Leishmaniose Visceral Transtornos da Nutrição Infantil |
description |
The role of the insulin-like growth factor I (IGF-I) system and nutritional status was studied in 241 children from a Brazilian area endemic for visceral leishmaniasis (VL). Thirtynine children had the active form, 20 were oligosymptomatic, 38 were asymptomatic and 144 were not infected. Serum concentrations of growth hormone (GH), total and free IGF-I and IGF binding-protein 3 (IGFBP3) were measured by radioimmunoassay. Nutritional status was evaluated by anthropometric indicators and biochemical measurements. Total and free IGF-I and IGFBP3 were significantly reduced in the active form. Z scores for total and free IGF-I and for IGFBP3 were found to be significantly lower for active VL and oligosymptomatic individuals than for asymptomatic individuals, but never reached values ≤2 SD. Median values of weight-for-age Z and height-for-age Z (HAZ) scores and albumin concentration were significantly different in the active VL group compared with the other groups. Multiple discriminant analysis selected albumin and HAZ score as predictors of active and oligosymptomatic VL. The lack of correlation between auxological data and serum concentrations of the GH/IGF axis components suggested that the primary cause of retarded growth in children with active VL is not dependent on IGF-I or IGFBP3, but rather on VL intrinsic factors that might secondarily involve the GH/IGF axis. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2016-01-26T11:43:20Z |
dc.date.available.fl_str_mv |
2016-01-26T11:43:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOMES, Claudia Maria de Castro et al. Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis. Transactions of the Royal Society of The Tropical Medicine and Hygiene, v. 101, n. 7, p. 660-667, 2007 |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/1058 |
dc.identifier.issn.-.fl_str_mv |
0035-9203 |
dc.identifier.doi.-.fl_str_mv |
10.1016/j.trstmh.2007.02.017 |
identifier_str_mv |
GOMES, Claudia Maria de Castro et al. Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis. Transactions of the Royal Society of The Tropical Medicine and Hygiene, v. 101, n. 7, p. 660-667, 2007 0035-9203 10.1016/j.trstmh.2007.02.017 |
url |
https://patua.iec.gov.br/handle/iec/1058 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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