Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4084 |
Resumo: | BACKGROUND: Enterovirus (EV) A71 and coxsackievirus (CV) A16 were the most frequent serotypes involved in hand, foot, and mouth disease (HFMD) outbreaks throughout Asia. In the past 5 years, however, CV-A6 has emerged as a new important pathogen worldwide, and more severe and extensive dermatologic presentations has been reported. OBJECTIVES: Identify the clinical spectrum for atypical HFMD and enterovirus serotypes in Belém, Pará, Amazon region of northern Brazil. STUDY DESIGN: A prospective ambulatory clinic-based surveillance conducted from January to June 2019, involving patients under 15 years with symptoms of HFMD. Stool, serum, oropharyngeal, and skin swab samples were analyzed. Real-time RT-PCR was performed to detect the viral genome of enteroviruses. Positive specimens were submitted to semi-nested PCR. Physical examinations and demographic data were recorded on a standardized form. RESULTS: 48 patients with symptoms of HFMD were included in the study and collected all samples according to protocol. Enteroviruses were detected in 83 % of patients. An atypical form of HFMD with vesiculobullous exanthema was present in 70 % (28/40); desquamation of the palms and soles detected in 90 % (36/40) and onychomadesis in 30 % (12/40) of patients. The serotype was identified in 22 patients, CV- A6 occurred in 81.8 % of them. CONCLUSION: This is the first ambulatory surveillance and virologic investigation involving HFMD performed in outpatients from Amazon region, Brazil. The detection of CV-A6 was related to atypical forms HFMD. Desquamation of the palms and soles and nail changes occurred with frequency, such as a late sequel in the HFMD disease. |
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Justino, Maria Cleonice AguiarMesquita, Deisiane da SSouza, Maurício FFarias, Francisco PAlves, Jainara Cristina dos SantosFerreira, James LLopes, Daniela PTavares, Fernando Neto2020-04-28T22:16:04Z2020-04-28T22:16:04Z2020JUSTINO, Maria Cleonice Aguiar et al. Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6. Journal of Clinical Virology, v. 126, n. xx, p.xx, May 2020.1873-5967https://patua.iec.gov.br/handle/iec/408410.1016/j.jcv.2020.104307BACKGROUND: Enterovirus (EV) A71 and coxsackievirus (CV) A16 were the most frequent serotypes involved in hand, foot, and mouth disease (HFMD) outbreaks throughout Asia. In the past 5 years, however, CV-A6 has emerged as a new important pathogen worldwide, and more severe and extensive dermatologic presentations has been reported. OBJECTIVES: Identify the clinical spectrum for atypical HFMD and enterovirus serotypes in Belém, Pará, Amazon region of northern Brazil. STUDY DESIGN: A prospective ambulatory clinic-based surveillance conducted from January to June 2019, involving patients under 15 years with symptoms of HFMD. Stool, serum, oropharyngeal, and skin swab samples were analyzed. Real-time RT-PCR was performed to detect the viral genome of enteroviruses. Positive specimens were submitted to semi-nested PCR. Physical examinations and demographic data were recorded on a standardized form. RESULTS: 48 patients with symptoms of HFMD were included in the study and collected all samples according to protocol. Enteroviruses were detected in 83 % of patients. An atypical form of HFMD with vesiculobullous exanthema was present in 70 % (28/40); desquamation of the palms and soles detected in 90 % (36/40) and onychomadesis in 30 % (12/40) of patients. The serotype was identified in 22 patients, CV- A6 occurred in 81.8 % of them. CONCLUSION: This is the first ambulatory surveillance and virologic investigation involving HFMD performed in outpatients from Amazon region, Brazil. The detection of CV-A6 was related to atypical forms HFMD. Desquamation of the palms and soles and nail changes occurred with frequency, such as a late sequel in the HFMD disease.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engElsevierAtypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEnterovírus / patogenicidadeDoença de Mão, Pé e Boca / patologiaDoença de Mão, Pé e Boca / virologiaInfecções por Coxsackievirus / virologiaExantema / virologiainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAtypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6.pdfAtypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/012fb355-fe4a-408e-bd2f-1db973a2678c/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/b914f9a9-2229-41c6-9c33-6665e2f6ca37/download11832eea31b16df8613079d742d61793MD52TEXTAtypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6.pdf.txtAtypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/398fadb5-73a3-4ab0-895a-03742645c4d7/downloade1c06d85ae7b8b032bef47e42e4c08f9MD55THUMBNAILAtypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6.pdf.jpgAtypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/358f49c6-9aaa-43a8-b465-17560a81f34b/download71859d578212107f7f8c49a4ce09d9eeMD56iec/40842022-10-21 00:06:30.744oai:patua.iec.gov.br:iec/4084https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-21T00:06:30Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 |
title |
Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 |
spellingShingle |
Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 Justino, Maria Cleonice Aguiar Enterovírus / patogenicidade Doença de Mão, Pé e Boca / patologia Doença de Mão, Pé e Boca / virologia Infecções por Coxsackievirus / virologia Exantema / virologia |
title_short |
Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 |
title_full |
Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 |
title_fullStr |
Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 |
title_full_unstemmed |
Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 |
title_sort |
Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 |
author |
Justino, Maria Cleonice Aguiar |
author_facet |
Justino, Maria Cleonice Aguiar Mesquita, Deisiane da S Souza, Maurício F Farias, Francisco P Alves, Jainara Cristina dos Santos Ferreira, James L Lopes, Daniela P Tavares, Fernando Neto |
author_role |
author |
author2 |
Mesquita, Deisiane da S Souza, Maurício F Farias, Francisco P Alves, Jainara Cristina dos Santos Ferreira, James L Lopes, Daniela P Tavares, Fernando Neto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Justino, Maria Cleonice Aguiar Mesquita, Deisiane da S Souza, Maurício F Farias, Francisco P Alves, Jainara Cristina dos Santos Ferreira, James L Lopes, Daniela P Tavares, Fernando Neto |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Enterovírus / patogenicidade Doença de Mão, Pé e Boca / patologia Doença de Mão, Pé e Boca / virologia Infecções por Coxsackievirus / virologia Exantema / virologia |
topic |
Enterovírus / patogenicidade Doença de Mão, Pé e Boca / patologia Doença de Mão, Pé e Boca / virologia Infecções por Coxsackievirus / virologia Exantema / virologia |
description |
BACKGROUND: Enterovirus (EV) A71 and coxsackievirus (CV) A16 were the most frequent serotypes involved in hand, foot, and mouth disease (HFMD) outbreaks throughout Asia. In the past 5 years, however, CV-A6 has emerged as a new important pathogen worldwide, and more severe and extensive dermatologic presentations has been reported. OBJECTIVES: Identify the clinical spectrum for atypical HFMD and enterovirus serotypes in Belém, Pará, Amazon region of northern Brazil. STUDY DESIGN: A prospective ambulatory clinic-based surveillance conducted from January to June 2019, involving patients under 15 years with symptoms of HFMD. Stool, serum, oropharyngeal, and skin swab samples were analyzed. Real-time RT-PCR was performed to detect the viral genome of enteroviruses. Positive specimens were submitted to semi-nested PCR. Physical examinations and demographic data were recorded on a standardized form. RESULTS: 48 patients with symptoms of HFMD were included in the study and collected all samples according to protocol. Enteroviruses were detected in 83 % of patients. An atypical form of HFMD with vesiculobullous exanthema was present in 70 % (28/40); desquamation of the palms and soles detected in 90 % (36/40) and onychomadesis in 30 % (12/40) of patients. The serotype was identified in 22 patients, CV- A6 occurred in 81.8 % of them. CONCLUSION: This is the first ambulatory surveillance and virologic investigation involving HFMD performed in outpatients from Amazon region, Brazil. The detection of CV-A6 was related to atypical forms HFMD. Desquamation of the palms and soles and nail changes occurred with frequency, such as a late sequel in the HFMD disease. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-04-28T22:16:04Z |
dc.date.available.fl_str_mv |
2020-04-28T22:16:04Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
JUSTINO, Maria Cleonice Aguiar et al. Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6. Journal of Clinical Virology, v. 126, n. xx, p.xx, May 2020. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4084 |
dc.identifier.issn.-.fl_str_mv |
1873-5967 |
dc.identifier.doi.-.fl_str_mv |
10.1016/j.jcv.2020.104307 |
identifier_str_mv |
JUSTINO, Maria Cleonice Aguiar et al. Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6. Journal of Clinical Virology, v. 126, n. xx, p.xx, May 2020. 1873-5967 10.1016/j.jcv.2020.104307 |
url |
https://patua.iec.gov.br/handle/iec/4084 |
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eng |
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eng |
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Elsevier |
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Elsevier |
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