Innate immunity to SARS-CoV-2 infection: a review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | http://patua.iec.gov.br/handle/iec/4599 |
Resumo: | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, first notified in China, has spread around the world causing high morbidity and mortality, which is due to factors such as the subversion of the immune response. The aims of the study are to summarise and present the immunopathological relationship of COVID-19 with innate immunity. This is a systematic review conducted by the National Library of Medicine - National Institutes of Health, USA (PUBMED), Latin American and Caribbean Literature on Health Sciences (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scientific Electronic Library Online (SCIELO) databases with clinical trials, in vitro assays, case-controls, cohort studies, systematic reviews and meta-analyses between February 2020 and July 2021. The version 2 of the Cochrane risk-of-bias tool for RCTs (RoB 2), Joana Briggs Institute (JBI) Critical Appraisal (for the review articles) and the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) tools were used to evaluate the quality and the risk of bias of the studies included in this review. The innate immune response through the generation of interferons, alternative pathways and complement system lectins and the joint action of innate immune cells and cytokines and chemokines lead to different clinical outcomes, taking into account the exacerbated inflammatory response and pathogenesis. Then, in addition to interacting as a bridge for adaptive immunity, the innate immune response plays an essential role in primary defense and is one of the starting points for immune evasion by SARS-CoV-2. |
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Silva, Marcos Jessé AbrahãoRodrigues, Yan CorrêaLima, Karla Valéria BatistaLima, Luana Nepomuceno Gondim Costa2022-08-16T12:12:57Z2022-08-16T12:12:57Z2022SILVA, Marcos Jessé Abrahão et al. Innate immunity to SARS-CoV-2 infection: a review. Epidemiology and Infection, v. 150, Article number e142, p. 1-16, July 2022. DOI: https://doi.org/10.1017/S095026882200125X. Disponível em: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/innate-immunity-to-sarscov2-infection-a-review/029C907BB6B3927A6AB00315707C4F59. Acesso em: 16 ago. 2022.1469-4409http://patua.iec.gov.br/handle/iec/459910.1017/S095026882200125XThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, first notified in China, has spread around the world causing high morbidity and mortality, which is due to factors such as the subversion of the immune response. The aims of the study are to summarise and present the immunopathological relationship of COVID-19 with innate immunity. This is a systematic review conducted by the National Library of Medicine - National Institutes of Health, USA (PUBMED), Latin American and Caribbean Literature on Health Sciences (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scientific Electronic Library Online (SCIELO) databases with clinical trials, in vitro assays, case-controls, cohort studies, systematic reviews and meta-analyses between February 2020 and July 2021. The version 2 of the Cochrane risk-of-bias tool for RCTs (RoB 2), Joana Briggs Institute (JBI) Critical Appraisal (for the review articles) and the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) tools were used to evaluate the quality and the risk of bias of the studies included in this review. The innate immune response through the generation of interferons, alternative pathways and complement system lectins and the joint action of innate immune cells and cytokines and chemokines lead to different clinical outcomes, taking into account the exacerbated inflammatory response and pathogenesis. Then, in addition to interacting as a bridge for adaptive immunity, the innate immune response plays an essential role in primary defense and is one of the starting points for immune evasion by SARS-CoV-2.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância Sanitária. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância Sanitária. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engCambridge University PressInnate immunity to SARS-CoV-2 infection: a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19SARS-CoV-2 / patogenicidadeEvasão da Resposta Imune / fisiologiaImunidade / fisiologiaRevisões Sistemáticas como Assuntoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALInnate immunity to SARS-CoV-2 infection: a review.pdfInnate immunity to SARS-CoV-2 infection: a review.pdfapplication/pdf733734https://patua.iec.gov.br/bitstreams/ccf87c4d-4161-4757-b7dd-507c911326a1/download7025aa5124cc71fb808e1f96c2cd36baMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/84c4797c-b94a-457d-aaa6-1ee8777b8ef6/download11832eea31b16df8613079d742d61793MD52TEXTInnate immunity to SARS-CoV-2 infection: a review.pdf.txtInnate immunity to SARS-CoV-2 infection: a review.pdf.txtExtracted texttext/plain90606https://patua.iec.gov.br/bitstreams/bfe9f75c-6c42-4483-87c3-4eb603e1e04a/download002ab6e2d1f6fda16ec37b6439c4f296MD55THUMBNAILInnate immunity to SARS-CoV-2 infection: a review.pdf.jpgInnate immunity to SARS-CoV-2 infection: a review.pdf.jpgGenerated Thumbnailimage/jpeg6060https://patua.iec.gov.br/bitstreams/260dde48-cd58-4d1b-b86b-3f72dcfaf2c0/download2141fabb932e238a06cca80972e61e06MD56iec/45992022-10-20 21:18:29.881oai:patua.iec.gov.br:iec/4599https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:18:29Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Innate immunity to SARS-CoV-2 infection: a review |
title |
Innate immunity to SARS-CoV-2 infection: a review |
spellingShingle |
Innate immunity to SARS-CoV-2 infection: a review Silva, Marcos Jessé Abrahão COVID-19 SARS-CoV-2 / patogenicidade Evasão da Resposta Imune / fisiologia Imunidade / fisiologia Revisões Sistemáticas como Assunto |
title_short |
Innate immunity to SARS-CoV-2 infection: a review |
title_full |
Innate immunity to SARS-CoV-2 infection: a review |
title_fullStr |
Innate immunity to SARS-CoV-2 infection: a review |
title_full_unstemmed |
Innate immunity to SARS-CoV-2 infection: a review |
title_sort |
Innate immunity to SARS-CoV-2 infection: a review |
author |
Silva, Marcos Jessé Abrahão |
author_facet |
Silva, Marcos Jessé Abrahão Rodrigues, Yan Corrêa Lima, Karla Valéria Batista Lima, Luana Nepomuceno Gondim Costa |
author_role |
author |
author2 |
Rodrigues, Yan Corrêa Lima, Karla Valéria Batista Lima, Luana Nepomuceno Gondim Costa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Marcos Jessé Abrahão Rodrigues, Yan Corrêa Lima, Karla Valéria Batista Lima, Luana Nepomuceno Gondim Costa |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 / patogenicidade Evasão da Resposta Imune / fisiologia Imunidade / fisiologia Revisões Sistemáticas como Assunto |
topic |
COVID-19 SARS-CoV-2 / patogenicidade Evasão da Resposta Imune / fisiologia Imunidade / fisiologia Revisões Sistemáticas como Assunto |
dc.subject.decsPrimary.none.fl_str_mv |
|
description |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, first notified in China, has spread around the world causing high morbidity and mortality, which is due to factors such as the subversion of the immune response. The aims of the study are to summarise and present the immunopathological relationship of COVID-19 with innate immunity. This is a systematic review conducted by the National Library of Medicine - National Institutes of Health, USA (PUBMED), Latin American and Caribbean Literature on Health Sciences (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scientific Electronic Library Online (SCIELO) databases with clinical trials, in vitro assays, case-controls, cohort studies, systematic reviews and meta-analyses between February 2020 and July 2021. The version 2 of the Cochrane risk-of-bias tool for RCTs (RoB 2), Joana Briggs Institute (JBI) Critical Appraisal (for the review articles) and the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) tools were used to evaluate the quality and the risk of bias of the studies included in this review. The innate immune response through the generation of interferons, alternative pathways and complement system lectins and the joint action of innate immune cells and cytokines and chemokines lead to different clinical outcomes, taking into account the exacerbated inflammatory response and pathogenesis. Then, in addition to interacting as a bridge for adaptive immunity, the innate immune response plays an essential role in primary defense and is one of the starting points for immune evasion by SARS-CoV-2. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-08-16T12:12:57Z |
dc.date.available.fl_str_mv |
2022-08-16T12:12:57Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Marcos Jessé Abrahão et al. Innate immunity to SARS-CoV-2 infection: a review. Epidemiology and Infection, v. 150, Article number e142, p. 1-16, July 2022. DOI: https://doi.org/10.1017/S095026882200125X. Disponível em: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/innate-immunity-to-sarscov2-infection-a-review/029C907BB6B3927A6AB00315707C4F59. Acesso em: 16 ago. 2022. |
dc.identifier.uri.fl_str_mv |
http://patua.iec.gov.br/handle/iec/4599 |
dc.identifier.issn.pt_BR.fl_str_mv |
1469-4409 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1017/S095026882200125X |
identifier_str_mv |
SILVA, Marcos Jessé Abrahão et al. Innate immunity to SARS-CoV-2 infection: a review. Epidemiology and Infection, v. 150, Article number e142, p. 1-16, July 2022. DOI: https://doi.org/10.1017/S095026882200125X. Disponível em: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/innate-immunity-to-sarscov2-infection-a-review/029C907BB6B3927A6AB00315707C4F59. Acesso em: 16 ago. 2022. 1469-4409 10.1017/S095026882200125X |
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http://patua.iec.gov.br/handle/iec/4599 |
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eng |
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Cambridge University Press |
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Cambridge University Press |
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