Innate immunity to SARS-CoV-2 infection: a review

Detalhes bibliográficos
Autor(a) principal: Silva, Marcos Jessé Abrahão
Data de Publicação: 2022
Outros Autores: Rodrigues, Yan Corrêa, Lima, Karla Valéria Batista, Lima, Luana Nepomuceno Gondim Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: http://patua.iec.gov.br/handle/iec/4599
Resumo: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, first notified in China, has spread around the world causing high morbidity and mortality, which is due to factors such as the subversion of the immune response. The aims of the study are to summarise and present the immunopathological relationship of COVID-19 with innate immunity. This is a systematic review conducted by the National Library of Medicine - National Institutes of Health, USA (PUBMED), Latin American and Caribbean Literature on Health Sciences (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scientific Electronic Library Online (SCIELO) databases with clinical trials, in vitro assays, case-controls, cohort studies, systematic reviews and meta-analyses between February 2020 and July 2021. The version 2 of the Cochrane risk-of-bias tool for RCTs (RoB 2), Joana Briggs Institute (JBI) Critical Appraisal (for the review articles) and the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) tools were used to evaluate the quality and the risk of bias of the studies included in this review. The innate immune response through the generation of interferons, alternative pathways and complement system lectins and the joint action of innate immune cells and cytokines and chemokines lead to different clinical outcomes, taking into account the exacerbated inflammatory response and pathogenesis. Then, in addition to interacting as a bridge for adaptive immunity, the innate immune response plays an essential role in primary defense and is one of the starting points for immune evasion by SARS-CoV-2.
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spelling Silva, Marcos Jessé AbrahãoRodrigues, Yan CorrêaLima, Karla Valéria BatistaLima, Luana Nepomuceno Gondim Costa2022-08-16T12:12:57Z2022-08-16T12:12:57Z2022SILVA, Marcos Jessé Abrahão et al. Innate immunity to SARS-CoV-2 infection: a review. Epidemiology and Infection, v. 150, Article number e142, p. 1-16, July 2022. DOI: https://doi.org/10.1017/S095026882200125X. Disponível em: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/innate-immunity-to-sarscov2-infection-a-review/029C907BB6B3927A6AB00315707C4F59. Acesso em: 16 ago. 2022.1469-4409http://patua.iec.gov.br/handle/iec/459910.1017/S095026882200125XThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, first notified in China, has spread around the world causing high morbidity and mortality, which is due to factors such as the subversion of the immune response. The aims of the study are to summarise and present the immunopathological relationship of COVID-19 with innate immunity. This is a systematic review conducted by the National Library of Medicine - National Institutes of Health, USA (PUBMED), Latin American and Caribbean Literature on Health Sciences (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scientific Electronic Library Online (SCIELO) databases with clinical trials, in vitro assays, case-controls, cohort studies, systematic reviews and meta-analyses between February 2020 and July 2021. The version 2 of the Cochrane risk-of-bias tool for RCTs (RoB 2), Joana Briggs Institute (JBI) Critical Appraisal (for the review articles) and the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) tools were used to evaluate the quality and the risk of bias of the studies included in this review. The innate immune response through the generation of interferons, alternative pathways and complement system lectins and the joint action of innate immune cells and cytokines and chemokines lead to different clinical outcomes, taking into account the exacerbated inflammatory response and pathogenesis. Then, in addition to interacting as a bridge for adaptive immunity, the innate immune response plays an essential role in primary defense and is one of the starting points for immune evasion by SARS-CoV-2.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância Sanitária. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância Sanitária. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engCambridge University PressInnate immunity to SARS-CoV-2 infection: a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19SARS-CoV-2 / patogenicidadeEvasão da Resposta Imune / fisiologiaImunidade / fisiologiaRevisões Sistemáticas como Assuntoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALInnate immunity to SARS-CoV-2 infection: a review.pdfInnate immunity to SARS-CoV-2 infection: a review.pdfapplication/pdf733734https://patua.iec.gov.br/bitstreams/ccf87c4d-4161-4757-b7dd-507c911326a1/download7025aa5124cc71fb808e1f96c2cd36baMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/84c4797c-b94a-457d-aaa6-1ee8777b8ef6/download11832eea31b16df8613079d742d61793MD52TEXTInnate immunity to SARS-CoV-2 infection: a review.pdf.txtInnate immunity to SARS-CoV-2 infection: a review.pdf.txtExtracted texttext/plain90606https://patua.iec.gov.br/bitstreams/bfe9f75c-6c42-4483-87c3-4eb603e1e04a/download002ab6e2d1f6fda16ec37b6439c4f296MD55THUMBNAILInnate immunity to SARS-CoV-2 infection: a review.pdf.jpgInnate immunity to SARS-CoV-2 infection: a review.pdf.jpgGenerated Thumbnailimage/jpeg6060https://patua.iec.gov.br/bitstreams/260dde48-cd58-4d1b-b86b-3f72dcfaf2c0/download2141fabb932e238a06cca80972e61e06MD56iec/45992022-10-20 21:18:29.881oai:patua.iec.gov.br:iec/4599https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:18:29Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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
dc.title.pt_BR.fl_str_mv Innate immunity to SARS-CoV-2 infection: a review
title Innate immunity to SARS-CoV-2 infection: a review
spellingShingle Innate immunity to SARS-CoV-2 infection: a review
Silva, Marcos Jessé Abrahão
COVID-19
SARS-CoV-2 / patogenicidade
Evasão da Resposta Imune / fisiologia
Imunidade / fisiologia
Revisões Sistemáticas como Assunto
title_short Innate immunity to SARS-CoV-2 infection: a review
title_full Innate immunity to SARS-CoV-2 infection: a review
title_fullStr Innate immunity to SARS-CoV-2 infection: a review
title_full_unstemmed Innate immunity to SARS-CoV-2 infection: a review
title_sort Innate immunity to SARS-CoV-2 infection: a review
author Silva, Marcos Jessé Abrahão
author_facet Silva, Marcos Jessé Abrahão
Rodrigues, Yan Corrêa
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
author_role author
author2 Rodrigues, Yan Corrêa
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Marcos Jessé Abrahão
Rodrigues, Yan Corrêa
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
dc.subject.decsPrimary.pt_BR.fl_str_mv COVID-19
SARS-CoV-2 / patogenicidade
Evasão da Resposta Imune / fisiologia
Imunidade / fisiologia
Revisões Sistemáticas como Assunto
topic COVID-19
SARS-CoV-2 / patogenicidade
Evasão da Resposta Imune / fisiologia
Imunidade / fisiologia
Revisões Sistemáticas como Assunto
dc.subject.decsPrimary.none.fl_str_mv
description The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, first notified in China, has spread around the world causing high morbidity and mortality, which is due to factors such as the subversion of the immune response. The aims of the study are to summarise and present the immunopathological relationship of COVID-19 with innate immunity. This is a systematic review conducted by the National Library of Medicine - National Institutes of Health, USA (PUBMED), Latin American and Caribbean Literature on Health Sciences (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scientific Electronic Library Online (SCIELO) databases with clinical trials, in vitro assays, case-controls, cohort studies, systematic reviews and meta-analyses between February 2020 and July 2021. The version 2 of the Cochrane risk-of-bias tool for RCTs (RoB 2), Joana Briggs Institute (JBI) Critical Appraisal (for the review articles) and the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) tools were used to evaluate the quality and the risk of bias of the studies included in this review. The innate immune response through the generation of interferons, alternative pathways and complement system lectins and the joint action of innate immune cells and cytokines and chemokines lead to different clinical outcomes, taking into account the exacerbated inflammatory response and pathogenesis. Then, in addition to interacting as a bridge for adaptive immunity, the innate immune response plays an essential role in primary defense and is one of the starting points for immune evasion by SARS-CoV-2.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-08-16T12:12:57Z
dc.date.available.fl_str_mv 2022-08-16T12:12:57Z
dc.date.issued.fl_str_mv 2022
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dc.identifier.citation.fl_str_mv SILVA, Marcos Jessé Abrahão et al. Innate immunity to SARS-CoV-2 infection: a review. Epidemiology and Infection, v. 150, Article number e142, p. 1-16, July 2022. DOI: https://doi.org/10.1017/S095026882200125X. Disponível em: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/innate-immunity-to-sarscov2-infection-a-review/029C907BB6B3927A6AB00315707C4F59. Acesso em: 16 ago. 2022.
dc.identifier.uri.fl_str_mv http://patua.iec.gov.br/handle/iec/4599
dc.identifier.issn.pt_BR.fl_str_mv 1469-4409
dc.identifier.doi.pt_BR.fl_str_mv 10.1017/S095026882200125X
identifier_str_mv SILVA, Marcos Jessé Abrahão et al. Innate immunity to SARS-CoV-2 infection: a review. Epidemiology and Infection, v. 150, Article number e142, p. 1-16, July 2022. DOI: https://doi.org/10.1017/S095026882200125X. Disponível em: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/innate-immunity-to-sarscov2-infection-a-review/029C907BB6B3927A6AB00315707C4F59. Acesso em: 16 ago. 2022.
1469-4409
10.1017/S095026882200125X
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