Hepatitis B prevalence among men who have sex with men in Brazil

Detalhes bibliográficos
Autor(a) principal: Castro, Ana Rita C. Motta
Data de Publicação: 2023
Outros Autores: Kerr, Lígia, Kendall, Carl, Mota, Rosa S, Guimarães, Mark Drew C, Leal, Andréa Fachel, Hamann, Edgar Merchan, Dourado, Inês, Veras, Maria Amélia, Brito, Ana Maria de, Pontes, Alexandre Kerr, Macena, Raimunda Hermelinda M, Knauth, Daniela, Lima, Luana Nepouceno Godim da Costa, Cavalcante, Socorro, Díaz-Bermúdez, Ximena P, Oliveira, Lisangela C, Magno, Laio, Camillo, Ana Calúdia, Lemos, Marcílio F, Silva, Vanessa Cristina M, Compri, Adriana P, Moreira, Regina Célia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/6819
Resumo: Hepatitis B virus (HBV) is a global public health problem and requires specific prevention actions, particularly focusing on the key populations, such as men who have sex with men (MSM). We aimed at assessing the prevalence of HBV infection, among MSM, in a multicity study in Brazil. In 2016, we conducted a survey using a respondent-driven sampling methodology in 12 Brazilian cities. Rapid tests (RT) were performed on 3178 samples from those MSM. Positive results were tested for HBV DNA and sequenced. If negative for HBV DNA, samples were tested for serological markers. The prevalence rate of HBV exposure and clearance was 10.1% (95% CI: 8.1–12.6), and 1.1% (95%; CI: 0.6–2.1) were confirmed to be HBsAg-positive. Of those samples tested for anti-HBs (n = 1033), only 74.4% presented a serological profile analogous to that elicited by hepatitis B vaccination. Among HBsAg-positive samples (n = 29), 72.4% were HBV DNA-positive, and from these, 18 were sequenced. HBV genotypes A, F, and G were found in 55.5%, 38.9%, and 5.6%, respectively. This study indicates high prevalence rates of MSM HBV exposure and a low positivity index for the serological marker of HBV vaccine immunity. These findings may contribute to the discussion of strategies to prevent hepatitis B and reinforce the importance of promoting HBV vaccination in this key population.
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spelling Castro, Ana Rita C. MottaKerr, LígiaKendall, CarlMota, Rosa SGuimarães, Mark Drew CLeal, Andréa FachelHamann, Edgar MerchanDourado, InêsVeras, Maria AméliaBrito, Ana Maria dePontes, Alexandre KerrMacena, Raimunda Hermelinda MKnauth, DanielaLima, Luana Nepouceno Godim da CostaCavalcante, SocorroDíaz-Bermúdez, Ximena POliveira, Lisangela CMagno, LaioCamillo, Ana CalúdiaLemos, Marcílio FSilva, Vanessa Cristina MCompri, Adriana PMoreira, Regina Célia2023-05-09T14:40:35Z2023-05-09T14:40:35Z2023CASTRO, Ana Rita C. Motta et al. Hepatitis B prevalence among men who have sex with men in Brazil. Tropical Medicine and Infectious Disease, v. 8, n. 4, p. 1-8, 2023. DOI: https://doi.org/10.3390/tropicalmed8040218. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142294/pdf/tropicalmed-08-00218.pdf2414-6366https://patua.iec.gov.br/handle/iec/681910.3390/tropicalmed8040218Hepatitis B virus (HBV) is a global public health problem and requires specific prevention actions, particularly focusing on the key populations, such as men who have sex with men (MSM). We aimed at assessing the prevalence of HBV infection, among MSM, in a multicity study in Brazil. In 2016, we conducted a survey using a respondent-driven sampling methodology in 12 Brazilian cities. Rapid tests (RT) were performed on 3178 samples from those MSM. Positive results were tested for HBV DNA and sequenced. If negative for HBV DNA, samples were tested for serological markers. The prevalence rate of HBV exposure and clearance was 10.1% (95% CI: 8.1–12.6), and 1.1% (95%; CI: 0.6–2.1) were confirmed to be HBsAg-positive. Of those samples tested for anti-HBs (n = 1033), only 74.4% presented a serological profile analogous to that elicited by hepatitis B vaccination. Among HBsAg-positive samples (n = 29), 72.4% were HBV DNA-positive, and from these, 18 were sequenced. HBV genotypes A, F, and G were found in 55.5%, 38.9%, and 5.6%, respectively. This study indicates high prevalence rates of MSM HBV exposure and a low positivity index for the serological marker of HBV vaccine immunity. These findings may contribute to the discussion of strategies to prevent hepatitis B and reinforce the importance of promoting HBV vaccination in this key population.The Brazilian Ministry of Health, through the Secretariat for Health Surveillance and the Department of Prevention, Surveillance and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis (Project # 914BRZ1138, BRAZIL, AIDS-SUS).Universidade Federal de Mato Grosso do Sul. Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição. Campo Grande, MS, Brazil / Fundação Oswaldo Cruz—Mato Grosso do Sul. Campo Grande, MS, Brazil.Universidade Federal do Ceará. Faculdade de Medicina. Saúde Comunitária. Fortaleza, CE, Brazil.Universidade Federal do Ceará. Faculdade de Medicina. Saúde Comunitária. Fortaleza, CE, Brazil / Tulane University. Global Community Health and Behavioral Sciences. New Orleans, LA, USA.Universidade Federal do Ceará. Departamento de Estatística e Matemática Aplicada. Fortaleza, CE, Brazil.Universidade Federal de Minas Gerais. Medicina Preventiva e Social. Belo Horizonte, MG, Brazil.Universidade Federal do Rio Grande do Sul. Departamento de Sociologia. Porto Alegre, RS, Brazil.Universidade de Brasília. Faculdade de Ciências da Saúde, Saúde Coletiva. Brasília, DF, Brazil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brazil.Faculdade de Ciências Médicas da Santa Casa de São Paulo. Departamento de Saúde Coletiva. São Paulo, SP, Brazil.Universidade Federal de Pernambuco. Recife, PE, Brazil / Fundação Oswaldo Cruz. Instituto de Pesquisas Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Psicologia. Rio de Janeiro, RJ, Brazil.Universidade Federal do Ceará. Faculdade de Medicina. Fortaleza, CE, Brazil.Universidade Federal do Rio Grande do Sul. Departamento de Medicina Social. Porto Alegre, RS, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Secretaria de Saúde do Estado do Ceará. Fortaleza, CE, Brazil.Universidade de Brasília. Centro de Ciências da Saúde. Brasília, DF, Brazil.Centro Universitário Autônomo do Brasil. Escola de Saúde. Curitiba, PR, Brazil.Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brazil.Fundação Alfredo da Mata. Centro de Aconselhamento. Manaus, AM, Brazil.Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites. São Paulo, SP, Brazil.Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites. São Paulo, SP, Brazil.Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites. São Paulo, SP, Brazil.Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites. 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dc.title.pt_BR.fl_str_mv Hepatitis B prevalence among men who have sex with men in Brazil
title Hepatitis B prevalence among men who have sex with men in Brazil
spellingShingle Hepatitis B prevalence among men who have sex with men in Brazil
Castro, Ana Rita C. Motta
Hepatite B / patologia
Vírus da Hepatite B / patogenicidade
Minorias Sexuais e de Gênero
Prevalência
title_short Hepatitis B prevalence among men who have sex with men in Brazil
title_full Hepatitis B prevalence among men who have sex with men in Brazil
title_fullStr Hepatitis B prevalence among men who have sex with men in Brazil
title_full_unstemmed Hepatitis B prevalence among men who have sex with men in Brazil
title_sort Hepatitis B prevalence among men who have sex with men in Brazil
author Castro, Ana Rita C. Motta
author_facet Castro, Ana Rita C. Motta
Kerr, Lígia
Kendall, Carl
Mota, Rosa S
Guimarães, Mark Drew C
Leal, Andréa Fachel
Hamann, Edgar Merchan
Dourado, Inês
Veras, Maria Amélia
Brito, Ana Maria de
Pontes, Alexandre Kerr
Macena, Raimunda Hermelinda M
Knauth, Daniela
Lima, Luana Nepouceno Godim da Costa
Cavalcante, Socorro
Díaz-Bermúdez, Ximena P
Oliveira, Lisangela C
Magno, Laio
Camillo, Ana Calúdia
Lemos, Marcílio F
Silva, Vanessa Cristina M
Compri, Adriana P
Moreira, Regina Célia
author_role author
author2 Kerr, Lígia
Kendall, Carl
Mota, Rosa S
Guimarães, Mark Drew C
Leal, Andréa Fachel
Hamann, Edgar Merchan
Dourado, Inês
Veras, Maria Amélia
Brito, Ana Maria de
Pontes, Alexandre Kerr
Macena, Raimunda Hermelinda M
Knauth, Daniela
Lima, Luana Nepouceno Godim da Costa
Cavalcante, Socorro
Díaz-Bermúdez, Ximena P
Oliveira, Lisangela C
Magno, Laio
Camillo, Ana Calúdia
Lemos, Marcílio F
Silva, Vanessa Cristina M
Compri, Adriana P
Moreira, Regina Célia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Ana Rita C. Motta
Kerr, Lígia
Kendall, Carl
Mota, Rosa S
Guimarães, Mark Drew C
Leal, Andréa Fachel
Hamann, Edgar Merchan
Dourado, Inês
Veras, Maria Amélia
Brito, Ana Maria de
Pontes, Alexandre Kerr
Macena, Raimunda Hermelinda M
Knauth, Daniela
Lima, Luana Nepouceno Godim da Costa
Cavalcante, Socorro
Díaz-Bermúdez, Ximena P
Oliveira, Lisangela C
Magno, Laio
Camillo, Ana Calúdia
Lemos, Marcílio F
Silva, Vanessa Cristina M
Compri, Adriana P
Moreira, Regina Célia
dc.subject.decsPrimary.pt_BR.fl_str_mv Hepatite B / patologia
Vírus da Hepatite B / patogenicidade
Minorias Sexuais e de Gênero
Prevalência
topic Hepatite B / patologia
Vírus da Hepatite B / patogenicidade
Minorias Sexuais e de Gênero
Prevalência
description Hepatitis B virus (HBV) is a global public health problem and requires specific prevention actions, particularly focusing on the key populations, such as men who have sex with men (MSM). We aimed at assessing the prevalence of HBV infection, among MSM, in a multicity study in Brazil. In 2016, we conducted a survey using a respondent-driven sampling methodology in 12 Brazilian cities. Rapid tests (RT) were performed on 3178 samples from those MSM. Positive results were tested for HBV DNA and sequenced. If negative for HBV DNA, samples were tested for serological markers. The prevalence rate of HBV exposure and clearance was 10.1% (95% CI: 8.1–12.6), and 1.1% (95%; CI: 0.6–2.1) were confirmed to be HBsAg-positive. Of those samples tested for anti-HBs (n = 1033), only 74.4% presented a serological profile analogous to that elicited by hepatitis B vaccination. Among HBsAg-positive samples (n = 29), 72.4% were HBV DNA-positive, and from these, 18 were sequenced. HBV genotypes A, F, and G were found in 55.5%, 38.9%, and 5.6%, respectively. This study indicates high prevalence rates of MSM HBV exposure and a low positivity index for the serological marker of HBV vaccine immunity. These findings may contribute to the discussion of strategies to prevent hepatitis B and reinforce the importance of promoting HBV vaccination in this key population.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-09T14:40:35Z
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dc.identifier.citation.fl_str_mv CASTRO, Ana Rita C. Motta et al. Hepatitis B prevalence among men who have sex with men in Brazil. Tropical Medicine and Infectious Disease, v. 8, n. 4, p. 1-8, 2023. DOI: https://doi.org/10.3390/tropicalmed8040218. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142294/pdf/tropicalmed-08-00218.pdf
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/6819
dc.identifier.issn.-.fl_str_mv 2414-6366
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/tropicalmed8040218
identifier_str_mv CASTRO, Ana Rita C. Motta et al. Hepatitis B prevalence among men who have sex with men in Brazil. Tropical Medicine and Infectious Disease, v. 8, n. 4, p. 1-8, 2023. DOI: https://doi.org/10.3390/tropicalmed8040218. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142294/pdf/tropicalmed-08-00218.pdf
2414-6366
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