Canine transmissible venereal tumor - From general to molecular characteristics: a review

Detalhes bibliográficos
Autor(a) principal: Faro, Thamirys Aline Silva
Data de Publicação: 2022
Outros Autores: Oliveira, Edivaldo Herculano Corrêa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/4699
Resumo: Cancer is a group of complex diseases resulting from the accumulation of genetic and epigenetic changes affecting control and activity of several genes, especially those involved in cell differentiation and growth processes, leading to an abnormal proliferation. When the disease reaches an advanced stage, cancer can lead to metastasis in other organs. Interestingly, recent studies have shown that some types of cancer spread not only through the body, but also can be transmitted among individuals. Therefore, these cancers are known as transmissible tumors. Among the three types of transmissible tumors that occur in nature, the canine transmissible venereal tumor (CTVT) is known as the oldest cancer in the world, since it was originated from a single individual 11 000 years ago. The disease has a worldwide distribution, and its occurrence has been documented since 1810. The CTVT presents three types of cytomorphological classification: lymphocytoid type, mixed type, and plasmacytoid type, the latter being chemoresistant due to overexpression of the ABCB1 gene, and consequently increase of the P-glycoprotein. More knowledge about the epidemiology and evolution of CTVT may help to elucidate the pathway and form of the global spread of the disease.
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spelling Faro, Thamirys Aline SilvaOliveira, Edivaldo Herculano Corrêa de2022-11-01T14:27:05Z2022-11-01T14:27:05Z2022FARO, Thamirys Aline Silva; OLIVEIRA, Edivaldo Herculano Corrêa de. Canine transmissible venereal tumor – From general to molecular characteristics: a review. Animal Genetics, v. xx, n. xx, p. xx, 2022. DOI: https://doi.org/10.1111/age.13260.1365-2052https://patua.iec.gov.br/handle/iec/469910.1111/age.13260Cancer is a group of complex diseases resulting from the accumulation of genetic and epigenetic changes affecting control and activity of several genes, especially those involved in cell differentiation and growth processes, leading to an abnormal proliferation. When the disease reaches an advanced stage, cancer can lead to metastasis in other organs. Interestingly, recent studies have shown that some types of cancer spread not only through the body, but also can be transmitted among individuals. Therefore, these cancers are known as transmissible tumors. Among the three types of transmissible tumors that occur in nature, the canine transmissible venereal tumor (CTVT) is known as the oldest cancer in the world, since it was originated from a single individual 11 000 years ago. The disease has a worldwide distribution, and its occurrence has been documented since 1810. The CTVT presents three types of cytomorphological classification: lymphocytoid type, mixed type, and plasmacytoid type, the latter being chemoresistant due to overexpression of the ABCB1 gene, and consequently increase of the P-glycoprotein. More knowledge about the epidemiology and evolution of CTVT may help to elucidate the pathway and form of the global spread of the disease.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CapesUniversidade Federal do Pará. Programa de Pós-Graduação em Genética e Biologia Molecular. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Laboratório de Citogenômica e Mutagênese Ambiental. Ananindeua, PA, Brasil.Universidade Federal do Pará. Programa de Pós-Graduação em Genética e Biologia Molecular. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Laboratório de Citogenômica e Mutagênese Ambiental. 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dc.title.pt_BR.fl_str_mv Canine transmissible venereal tumor - From general to molecular characteristics: a review
title Canine transmissible venereal tumor - From general to molecular characteristics: a review
spellingShingle Canine transmissible venereal tumor - From general to molecular characteristics: a review
Faro, Thamirys Aline Silva
Neoplasias / veterinária
Cães / anatomia & histologia
Tumores Venéreos Veterinários
title_short Canine transmissible venereal tumor - From general to molecular characteristics: a review
title_full Canine transmissible venereal tumor - From general to molecular characteristics: a review
title_fullStr Canine transmissible venereal tumor - From general to molecular characteristics: a review
title_full_unstemmed Canine transmissible venereal tumor - From general to molecular characteristics: a review
title_sort Canine transmissible venereal tumor - From general to molecular characteristics: a review
author Faro, Thamirys Aline Silva
author_facet Faro, Thamirys Aline Silva
Oliveira, Edivaldo Herculano Corrêa de
author_role author
author2 Oliveira, Edivaldo Herculano Corrêa de
author2_role author
dc.contributor.author.fl_str_mv Faro, Thamirys Aline Silva
Oliveira, Edivaldo Herculano Corrêa de
dc.subject.decsPrimary.pt_BR.fl_str_mv Neoplasias / veterinária
Cães / anatomia & histologia
Tumores Venéreos Veterinários
topic Neoplasias / veterinária
Cães / anatomia & histologia
Tumores Venéreos Veterinários
description Cancer is a group of complex diseases resulting from the accumulation of genetic and epigenetic changes affecting control and activity of several genes, especially those involved in cell differentiation and growth processes, leading to an abnormal proliferation. When the disease reaches an advanced stage, cancer can lead to metastasis in other organs. Interestingly, recent studies have shown that some types of cancer spread not only through the body, but also can be transmitted among individuals. Therefore, these cancers are known as transmissible tumors. Among the three types of transmissible tumors that occur in nature, the canine transmissible venereal tumor (CTVT) is known as the oldest cancer in the world, since it was originated from a single individual 11 000 years ago. The disease has a worldwide distribution, and its occurrence has been documented since 1810. The CTVT presents three types of cytomorphological classification: lymphocytoid type, mixed type, and plasmacytoid type, the latter being chemoresistant due to overexpression of the ABCB1 gene, and consequently increase of the P-glycoprotein. More knowledge about the epidemiology and evolution of CTVT may help to elucidate the pathway and form of the global spread of the disease.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-11-01T14:27:05Z
dc.date.available.fl_str_mv 2022-11-01T14:27:05Z
dc.date.issued.fl_str_mv 2022
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dc.identifier.citation.fl_str_mv FARO, Thamirys Aline Silva; OLIVEIRA, Edivaldo Herculano Corrêa de. Canine transmissible venereal tumor – From general to molecular characteristics: a review. Animal Genetics, v. xx, n. xx, p. xx, 2022. DOI: https://doi.org/10.1111/age.13260.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/4699
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dc.identifier.doi.pt_BR.fl_str_mv 10.1111/age.13260
identifier_str_mv FARO, Thamirys Aline Silva; OLIVEIRA, Edivaldo Herculano Corrêa de. Canine transmissible venereal tumor – From general to molecular characteristics: a review. Animal Genetics, v. xx, n. xx, p. xx, 2022. DOI: https://doi.org/10.1111/age.13260.
1365-2052
10.1111/age.13260
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