Canine transmissible venereal tumor - From general to molecular characteristics: a review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4699 |
Resumo: | Cancer is a group of complex diseases resulting from the accumulation of genetic and epigenetic changes affecting control and activity of several genes, especially those involved in cell differentiation and growth processes, leading to an abnormal proliferation. When the disease reaches an advanced stage, cancer can lead to metastasis in other organs. Interestingly, recent studies have shown that some types of cancer spread not only through the body, but also can be transmitted among individuals. Therefore, these cancers are known as transmissible tumors. Among the three types of transmissible tumors that occur in nature, the canine transmissible venereal tumor (CTVT) is known as the oldest cancer in the world, since it was originated from a single individual 11 000 years ago. The disease has a worldwide distribution, and its occurrence has been documented since 1810. The CTVT presents three types of cytomorphological classification: lymphocytoid type, mixed type, and plasmacytoid type, the latter being chemoresistant due to overexpression of the ABCB1 gene, and consequently increase of the P-glycoprotein. More knowledge about the epidemiology and evolution of CTVT may help to elucidate the pathway and form of the global spread of the disease. |
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Faro, Thamirys Aline SilvaOliveira, Edivaldo Herculano Corrêa de2022-11-01T14:27:05Z2022-11-01T14:27:05Z2022FARO, Thamirys Aline Silva; OLIVEIRA, Edivaldo Herculano Corrêa de. Canine transmissible venereal tumor – From general to molecular characteristics: a review. Animal Genetics, v. xx, n. xx, p. xx, 2022. DOI: https://doi.org/10.1111/age.13260.1365-2052https://patua.iec.gov.br/handle/iec/469910.1111/age.13260Cancer is a group of complex diseases resulting from the accumulation of genetic and epigenetic changes affecting control and activity of several genes, especially those involved in cell differentiation and growth processes, leading to an abnormal proliferation. When the disease reaches an advanced stage, cancer can lead to metastasis in other organs. Interestingly, recent studies have shown that some types of cancer spread not only through the body, but also can be transmitted among individuals. Therefore, these cancers are known as transmissible tumors. Among the three types of transmissible tumors that occur in nature, the canine transmissible venereal tumor (CTVT) is known as the oldest cancer in the world, since it was originated from a single individual 11 000 years ago. The disease has a worldwide distribution, and its occurrence has been documented since 1810. The CTVT presents three types of cytomorphological classification: lymphocytoid type, mixed type, and plasmacytoid type, the latter being chemoresistant due to overexpression of the ABCB1 gene, and consequently increase of the P-glycoprotein. More knowledge about the epidemiology and evolution of CTVT may help to elucidate the pathway and form of the global spread of the disease.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CapesUniversidade Federal do Pará. Programa de Pós-Graduação em Genética e Biologia Molecular. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Laboratório de Citogenômica e Mutagênese Ambiental. Ananindeua, PA, Brasil.Universidade Federal do Pará. Programa de Pós-Graduação em Genética e Biologia Molecular. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Laboratório de Citogenômica e Mutagênese Ambiental. 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dc.title.pt_BR.fl_str_mv |
Canine transmissible venereal tumor - From general to molecular characteristics: a review |
title |
Canine transmissible venereal tumor - From general to molecular characteristics: a review |
spellingShingle |
Canine transmissible venereal tumor - From general to molecular characteristics: a review Faro, Thamirys Aline Silva Neoplasias / veterinária Cães / anatomia & histologia Tumores Venéreos Veterinários |
title_short |
Canine transmissible venereal tumor - From general to molecular characteristics: a review |
title_full |
Canine transmissible venereal tumor - From general to molecular characteristics: a review |
title_fullStr |
Canine transmissible venereal tumor - From general to molecular characteristics: a review |
title_full_unstemmed |
Canine transmissible venereal tumor - From general to molecular characteristics: a review |
title_sort |
Canine transmissible venereal tumor - From general to molecular characteristics: a review |
author |
Faro, Thamirys Aline Silva |
author_facet |
Faro, Thamirys Aline Silva Oliveira, Edivaldo Herculano Corrêa de |
author_role |
author |
author2 |
Oliveira, Edivaldo Herculano Corrêa de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Faro, Thamirys Aline Silva Oliveira, Edivaldo Herculano Corrêa de |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Neoplasias / veterinária Cães / anatomia & histologia Tumores Venéreos Veterinários |
topic |
Neoplasias / veterinária Cães / anatomia & histologia Tumores Venéreos Veterinários |
description |
Cancer is a group of complex diseases resulting from the accumulation of genetic and epigenetic changes affecting control and activity of several genes, especially those involved in cell differentiation and growth processes, leading to an abnormal proliferation. When the disease reaches an advanced stage, cancer can lead to metastasis in other organs. Interestingly, recent studies have shown that some types of cancer spread not only through the body, but also can be transmitted among individuals. Therefore, these cancers are known as transmissible tumors. Among the three types of transmissible tumors that occur in nature, the canine transmissible venereal tumor (CTVT) is known as the oldest cancer in the world, since it was originated from a single individual 11 000 years ago. The disease has a worldwide distribution, and its occurrence has been documented since 1810. The CTVT presents three types of cytomorphological classification: lymphocytoid type, mixed type, and plasmacytoid type, the latter being chemoresistant due to overexpression of the ABCB1 gene, and consequently increase of the P-glycoprotein. More knowledge about the epidemiology and evolution of CTVT may help to elucidate the pathway and form of the global spread of the disease. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-11-01T14:27:05Z |
dc.date.available.fl_str_mv |
2022-11-01T14:27:05Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FARO, Thamirys Aline Silva; OLIVEIRA, Edivaldo Herculano Corrêa de. Canine transmissible venereal tumor – From general to molecular characteristics: a review. Animal Genetics, v. xx, n. xx, p. xx, 2022. DOI: https://doi.org/10.1111/age.13260. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4699 |
dc.identifier.issn.-.fl_str_mv |
1365-2052 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1111/age.13260 |
identifier_str_mv |
FARO, Thamirys Aline Silva; OLIVEIRA, Edivaldo Herculano Corrêa de. Canine transmissible venereal tumor – From general to molecular characteristics: a review. Animal Genetics, v. xx, n. xx, p. xx, 2022. DOI: https://doi.org/10.1111/age.13260. 1365-2052 10.1111/age.13260 |
url |
https://patua.iec.gov.br/handle/iec/4699 |
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eng |
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eng |
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openAccess |
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Wiley |
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Wiley |
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reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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