HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4459 |
Resumo: | BACKGROUND: Penile cancer (PeCa) is a rare disease, but its incidence has increased worldwide, mostly in HPV+ patients. Nevertheless, there is still no targeted treatment for this carcinoma. OBJECTIVE: To predict the main signaling pathways involved in penile tumorigenesis and its potential drug targets. METHODS: Genome-wide copy number profiling was performed in 28 PeCa. Integration analysis of CNAs and miRNAs and mRNA targets was performed by DIANA-TarBase v.8. The potential impact of the miRNAs/target genes on biological pathways was assessed by DIANA-miRPath v.3.0. For each miRNA, KEGG pathways were generated based on the tarbase and microT-CDS algorithms. Pharmaco-miR was used to identify associations between miRNAs and their target genes to predict druggable targets. RESULTS: 269 miRNAs and 2,395 genes were mapped in cytobands with CNAs. The comparison of the miRNAs mapped at these cytobands and the miRNAs that were predicted to regulate the genes also mapped in these regions, resulted in a set of common 35 miRNAs and 292 genes. Enrichment pathway revealed their involvement in five top signaling pathways. EGFR and COX2 were identified as potential druggable targets. CONCLUSION: Our data indicate the potential use of EGFR and COX2 inhibitors as a target treatment for PeCa patients. |
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Silva, Jenilson daNogueira, LeudivanCoelho, RonaldDeus, AmandaKhayat, AndréMarchi, RafaelOliveira, Edivaldo Herculano Corrêa deSantos, Ana Paula dosCavalli, LucianePereira, Silma2021-10-19T14:20:58Z2021-10-19T14:20:58Z2021SILVA, Jenilson da et al. HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets. Cancer Biomarkers, v. 32, n. 2, p. 147-160, 2021.1574-0153https://patua.iec.gov.br/handle/iec/445910.3233/CBM-210035.BACKGROUND: Penile cancer (PeCa) is a rare disease, but its incidence has increased worldwide, mostly in HPV+ patients. Nevertheless, there is still no targeted treatment for this carcinoma. OBJECTIVE: To predict the main signaling pathways involved in penile tumorigenesis and its potential drug targets. METHODS: Genome-wide copy number profiling was performed in 28 PeCa. Integration analysis of CNAs and miRNAs and mRNA targets was performed by DIANA-TarBase v.8. The potential impact of the miRNAs/target genes on biological pathways was assessed by DIANA-miRPath v.3.0. For each miRNA, KEGG pathways were generated based on the tarbase and microT-CDS algorithms. Pharmaco-miR was used to identify associations between miRNAs and their target genes to predict druggable targets. RESULTS: 269 miRNAs and 2,395 genes were mapped in cytobands with CNAs. The comparison of the miRNAs mapped at these cytobands and the miRNAs that were predicted to regulate the genes also mapped in these regions, resulted in a set of common 35 miRNAs and 292 genes. Enrichment pathway revealed their involvement in five top signaling pathways. EGFR and COX2 were identified as potential druggable targets. CONCLUSION: Our data indicate the potential use of EGFR and COX2 inhibitors as a target treatment for PeCa patients.Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Federal University of Maranhão. Postgraduate Program in Health Science. São Luís, MA, Brazil.Federal University of Maranhão. Postgraduate Program in Health Science. São Luís, MA, Brazil / Aldenora Bello Cancer Hospital. São Luís, MA, Brazil.Aldenora Bello Cancer Hospital. São Luís, MA, Brazil.Federal University of Maranhão. Postgraduate Program in Health Science. São Luís, MA, Brazil / Aldenora Bello Cancer Hospital. São Luís, MA, Brazil.Federal University of Pará. Oncology Research Center. Belém, PA, Brazil.Faculdades Pequeno Príncipe. Research Institute Pelé Pequeno Príncipe. Curitiba, PR, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Cultura de Tecidos e Citogenética. Ananindeua, PA, Brasil.Federal University of Maranhão. Department of Physiological Sciences. São Luís, MA, Brazil.Faculdades Pequeno Príncipe. Research Institute Pelé Pequeno Príncipe. Curitiba, PR, Brazil.Federal University of Maranhão. Department of Biology. Laboratory of Genetics and Molecular Biology. São Luís, MA, Brazil.engIOS PressHPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePênis / anatomia & histologiaNeoplasias Penianas / patologiaBiomarcadores TumoraisPapillomaviridae / patogenicidadeCarcinogênese / genéticainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALHPV-associated penile cancer: Impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets.pdfHPV-associated penile cancer: Impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/038c15f0-ead8-4a92-875c-9bc8d4b5efeb/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/a3181f6e-5569-41ef-8b7d-fff166bc53c4/download11832eea31b16df8613079d742d61793MD52TEXTHPV-associated penile cancer: Impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets.pdf.txtHPV-associated penile cancer: Impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/a7418b18-66db-4f9d-a881-38ed0411e526/downloade1c06d85ae7b8b032bef47e42e4c08f9MD55THUMBNAILHPV-associated penile cancer: Impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets.pdf.jpgHPV-associated penile cancer: Impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/34a421ae-618c-4f0a-90cc-232dea110720/download71859d578212107f7f8c49a4ce09d9eeMD56iec/44592022-10-20 21:28:00.109oai:patua.iec.gov.br:iec/4459https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:28Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets |
title |
HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets |
spellingShingle |
HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets Silva, Jenilson da Pênis / anatomia & histologia Neoplasias Penianas / patologia Biomarcadores Tumorais Papillomaviridae / patogenicidade Carcinogênese / genética |
title_short |
HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets |
title_full |
HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets |
title_fullStr |
HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets |
title_full_unstemmed |
HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets |
title_sort |
HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets |
author |
Silva, Jenilson da |
author_facet |
Silva, Jenilson da Nogueira, Leudivan Coelho, Ronald Deus, Amanda Khayat, André Marchi, Rafael Oliveira, Edivaldo Herculano Corrêa de Santos, Ana Paula dos Cavalli, Luciane Pereira, Silma |
author_role |
author |
author2 |
Nogueira, Leudivan Coelho, Ronald Deus, Amanda Khayat, André Marchi, Rafael Oliveira, Edivaldo Herculano Corrêa de Santos, Ana Paula dos Cavalli, Luciane Pereira, Silma |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Jenilson da Nogueira, Leudivan Coelho, Ronald Deus, Amanda Khayat, André Marchi, Rafael Oliveira, Edivaldo Herculano Corrêa de Santos, Ana Paula dos Cavalli, Luciane Pereira, Silma |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Pênis / anatomia & histologia Neoplasias Penianas / patologia Biomarcadores Tumorais Papillomaviridae / patogenicidade Carcinogênese / genética |
topic |
Pênis / anatomia & histologia Neoplasias Penianas / patologia Biomarcadores Tumorais Papillomaviridae / patogenicidade Carcinogênese / genética |
description |
BACKGROUND: Penile cancer (PeCa) is a rare disease, but its incidence has increased worldwide, mostly in HPV+ patients. Nevertheless, there is still no targeted treatment for this carcinoma. OBJECTIVE: To predict the main signaling pathways involved in penile tumorigenesis and its potential drug targets. METHODS: Genome-wide copy number profiling was performed in 28 PeCa. Integration analysis of CNAs and miRNAs and mRNA targets was performed by DIANA-TarBase v.8. The potential impact of the miRNAs/target genes on biological pathways was assessed by DIANA-miRPath v.3.0. For each miRNA, KEGG pathways were generated based on the tarbase and microT-CDS algorithms. Pharmaco-miR was used to identify associations between miRNAs and their target genes to predict druggable targets. RESULTS: 269 miRNAs and 2,395 genes were mapped in cytobands with CNAs. The comparison of the miRNAs mapped at these cytobands and the miRNAs that were predicted to regulate the genes also mapped in these regions, resulted in a set of common 35 miRNAs and 292 genes. Enrichment pathway revealed their involvement in five top signaling pathways. EGFR and COX2 were identified as potential druggable targets. CONCLUSION: Our data indicate the potential use of EGFR and COX2 inhibitors as a target treatment for PeCa patients. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-10-19T14:20:58Z |
dc.date.available.fl_str_mv |
2021-10-19T14:20:58Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Jenilson da et al. HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets. Cancer Biomarkers, v. 32, n. 2, p. 147-160, 2021. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4459 |
dc.identifier.issn.-.fl_str_mv |
1574-0153 |
dc.identifier.doi.-.fl_str_mv |
10.3233/CBM-210035. |
identifier_str_mv |
SILVA, Jenilson da et al. HPV-associated penile cancer: impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets. Cancer Biomarkers, v. 32, n. 2, p. 147-160, 2021. 1574-0153 10.3233/CBM-210035. |
url |
https://patua.iec.gov.br/handle/iec/4459 |
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eng |
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eng |
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info:eu-repo/semantics/embargoedAccess |
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IOS Press |
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IOS Press |
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