Transplante ovariano: destaques na reprodução de primatas não humanos
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4027 |
Resumo: | Background: Ovarian transplantation in nonhuman primates (NHP) has been used as a strategy for the development of experimental models for biomedical research in the reproductive area. The prospects for application of this technique range from the restoration of female fertility to the conservation of endangered wild animals. However, studies with NHP were performed mostly focusing on the ovarian transplantation of cryopreserved tissue, in order to simulate the reality of human species, as well as aiming to obtain experimental models suitable for comparative studies. On the other hand, ovarian transplantation could be applied also in NHP species preservation. Review: According to the last census (2012-2014) of the International Union for Conservation of Nature (IUCN), currently, more than half of the 633 types of primates known around the world are in danger of disappearing forever due to the continued destruction of their natural habitat by human activities. Thus, there is an interest to expose the possible methods of ovarian preservation followed by transplantation that can be employed to promote the conservation of endangered NHP. Despite the positive results obtained with avascular autograft of fresh ovarian tissue in NHP, it is important to bring in mind the significant loss of follicles as a result of this procedure due to ischemia and reperfusion during the first days after grafting. This phenomenon leads to the production of reactive oxygen species (ROS) such as hydrogen peroxide, superoxide anion and hydroxyl radical, which are responsible by lipid peroxidation, cell membrane damage and subsequent follicular atresia. An alternative to counteract this oxidative stress consists in the application/administration of different sources of antioxidants previously or during grafting, in the grafted tissue or in the animal receiving the transplant. The most used compounds with a claimed radical scavenger activity are catalase, trolox and some vitamins. In some cases, antioxidants are combined with angiogenic factors, e.g. vascular endothelial growth factor (VEGF) to stimulate revascularization. Another option to avoid the damage caused by ischemia is the whole ovarian transplantation with vascular anastomosis. Therefore, a greater proportion of the pool of follicles survives the procedure and the complete ovary is grafted and not only tissue fragments. However, the vascular microsurgical procedure is complex and, when it is associated with cryopreservation the risks of follicular loss and tissue damage due to improper perfusion are larger. In this context, the aim of this review is to cover important concepts about ovarian transplantation and its current situation in NHP, showing its importance and its advances to reproduction, especially to preserve those endangered ones. Conclusion: Despite advances in tissue response to various applications of the ovarian tissue transplantation reported in this review, it is clear that this technique has been used with paucity as a tool for the conservation of species of PNH endangered. The need for optimization of transplantation techniques, so as to reduce the loss of the follicles during the grafting processes and revascularization, determining the ideal location for the graft, the graft longevity and where in the amount of ovarian tissue required to preserve fertility still are points to be clarified. In this sense, research is ongoing and the perspectives are positive not only to use NHP as a model for human, but also for those endangered species. |
id |
IEC-2_fb9e56c7519d9b8f31a17550d7c69f88 |
---|---|
oai_identifier_str |
oai:patua.iec.gov.br:iec/4027 |
network_acronym_str |
IEC-2 |
network_name_str |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
repository_id_str |
|
spelling |
Scalercio, Sarah Raphaella Rocha de AzevedoSantana, Luana de Nazaré da SilvaDomingues, Sheyla Farhayldes SouzaAmorim, Christiani AndradeSantos, Regiane Rodrigues dos2020-02-12T18:02:09Z2020-02-12T18:02:09Z2015SCALERCIO, Sarah Raphaella Rocha de Azevedo et al. Transplante ovariano: Destaques na reprodução de primatas não humanos. Acta scientiae veterinariae, v. 43, n. 1315, p. 1-12, 2015.1679-9216https://patua.iec.gov.br/handle/iec/4027Background: Ovarian transplantation in nonhuman primates (NHP) has been used as a strategy for the development of experimental models for biomedical research in the reproductive area. The prospects for application of this technique range from the restoration of female fertility to the conservation of endangered wild animals. However, studies with NHP were performed mostly focusing on the ovarian transplantation of cryopreserved tissue, in order to simulate the reality of human species, as well as aiming to obtain experimental models suitable for comparative studies. On the other hand, ovarian transplantation could be applied also in NHP species preservation. Review: According to the last census (2012-2014) of the International Union for Conservation of Nature (IUCN), currently, more than half of the 633 types of primates known around the world are in danger of disappearing forever due to the continued destruction of their natural habitat by human activities. Thus, there is an interest to expose the possible methods of ovarian preservation followed by transplantation that can be employed to promote the conservation of endangered NHP. Despite the positive results obtained with avascular autograft of fresh ovarian tissue in NHP, it is important to bring in mind the significant loss of follicles as a result of this procedure due to ischemia and reperfusion during the first days after grafting. This phenomenon leads to the production of reactive oxygen species (ROS) such as hydrogen peroxide, superoxide anion and hydroxyl radical, which are responsible by lipid peroxidation, cell membrane damage and subsequent follicular atresia. An alternative to counteract this oxidative stress consists in the application/administration of different sources of antioxidants previously or during grafting, in the grafted tissue or in the animal receiving the transplant. The most used compounds with a claimed radical scavenger activity are catalase, trolox and some vitamins. In some cases, antioxidants are combined with angiogenic factors, e.g. vascular endothelial growth factor (VEGF) to stimulate revascularization. Another option to avoid the damage caused by ischemia is the whole ovarian transplantation with vascular anastomosis. Therefore, a greater proportion of the pool of follicles survives the procedure and the complete ovary is grafted and not only tissue fragments. However, the vascular microsurgical procedure is complex and, when it is associated with cryopreservation the risks of follicular loss and tissue damage due to improper perfusion are larger. In this context, the aim of this review is to cover important concepts about ovarian transplantation and its current situation in NHP, showing its importance and its advances to reproduction, especially to preserve those endangered ones. Conclusion: Despite advances in tissue response to various applications of the ovarian tissue transplantation reported in this review, it is clear that this technique has been used with paucity as a tool for the conservation of species of PNH endangered. The need for optimization of transplantation techniques, so as to reduce the loss of the follicles during the grafting processes and revascularization, determining the ideal location for the graft, the graft longevity and where in the amount of ovarian tissue required to preserve fertility still are points to be clarified. In this sense, research is ongoing and the perspectives are positive not only to use NHP as a model for human, but also for those endangered species.CAPES - processo no. 0503-12-6/2012Universidade Federal do Pará. Laboratório de Biologia e Medicina de Animais Silvestres da Amazônia. Castanhal, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro Nacional de Primatas. Ananindeua, PA, Brasil.Universidade Federal do Pará. Laboratório de Neuroproteção e Neuroregeneração Experimental. Belém, PA, Brasil.Universidade Federal do Pará. Laboratório de Biologia e Medicina de Animais Silvestres da Amazônia. Castanhal, PA, Brazil.Université Catholique de Louvain. Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique. Brussels, Belgium.Universidade Federal do Pará. Laboratório de Biologia e Medicina de Animais Silvestres da Amazônia. Castanhal, PA, Brazil / Utrecht University. Faculty of Veterinary Medicine. Utrecht, The Netherlands.porUniversidade Federal do Rio Grande do Sul. Faculdade de VeterináriaTransplante ovariano: destaques na reprodução de primatas não humanosOvarian transplantation: highlight to non-human primates reproductioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePrimatas / anatomia & histologiaOvário / anatomia & histologiaTransplante / veterináriaReproduçãoTécnicas Reprodutivas / veterináriaPesquisa Biomédicainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALTransplante ovariano: destaques na reprodução de primatas não humanos.pdfTransplante ovariano: destaques na reprodução de primatas não humanos.pdfapplication/pdf649840https://patua.iec.gov.br/bitstreams/fe85d3bb-f35a-4f92-b6e4-0565630cb605/download24656042a803d609d21433a5bb72bc8eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/2537303f-8a73-42ac-91df-63032ee40e28/download11832eea31b16df8613079d742d61793MD52TEXTTransplante ovariano: destaques na reprodução de primatas não humanos.pdf.txtTransplante ovariano: destaques na reprodução de primatas não humanos.pdf.txtExtracted texttext/plain58074https://patua.iec.gov.br/bitstreams/20cec042-908a-4e65-8190-d58927f6a3d5/downloadef6c327495f582e6a96bf3b816d72d3bMD55THUMBNAILTransplante ovariano: destaques na reprodução de primatas não humanos.pdf.jpgTransplante ovariano: destaques na reprodução de primatas não humanos.pdf.jpgGenerated Thumbnailimage/jpeg5831https://patua.iec.gov.br/bitstreams/57833bda-f1e0-4958-af65-4b021083a436/downloadc81e167bdb8a5244a23a8dc59505cf08MD56iec/40272022-10-20 21:10:25.652oai:patua.iec.gov.br:iec/4027https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:10:25Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Transplante ovariano: destaques na reprodução de primatas não humanos |
dc.title.alternative.pt_BR.fl_str_mv |
Ovarian transplantation: highlight to non-human primates reproduction |
title |
Transplante ovariano: destaques na reprodução de primatas não humanos |
spellingShingle |
Transplante ovariano: destaques na reprodução de primatas não humanos Scalercio, Sarah Raphaella Rocha de Azevedo Primatas / anatomia & histologia Ovário / anatomia & histologia Transplante / veterinária Reprodução Técnicas Reprodutivas / veterinária Pesquisa Biomédica |
title_short |
Transplante ovariano: destaques na reprodução de primatas não humanos |
title_full |
Transplante ovariano: destaques na reprodução de primatas não humanos |
title_fullStr |
Transplante ovariano: destaques na reprodução de primatas não humanos |
title_full_unstemmed |
Transplante ovariano: destaques na reprodução de primatas não humanos |
title_sort |
Transplante ovariano: destaques na reprodução de primatas não humanos |
author |
Scalercio, Sarah Raphaella Rocha de Azevedo |
author_facet |
Scalercio, Sarah Raphaella Rocha de Azevedo Santana, Luana de Nazaré da Silva Domingues, Sheyla Farhayldes Souza Amorim, Christiani Andrade Santos, Regiane Rodrigues dos |
author_role |
author |
author2 |
Santana, Luana de Nazaré da Silva Domingues, Sheyla Farhayldes Souza Amorim, Christiani Andrade Santos, Regiane Rodrigues dos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Scalercio, Sarah Raphaella Rocha de Azevedo Santana, Luana de Nazaré da Silva Domingues, Sheyla Farhayldes Souza Amorim, Christiani Andrade Santos, Regiane Rodrigues dos |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Primatas / anatomia & histologia Ovário / anatomia & histologia Transplante / veterinária Reprodução Técnicas Reprodutivas / veterinária Pesquisa Biomédica |
topic |
Primatas / anatomia & histologia Ovário / anatomia & histologia Transplante / veterinária Reprodução Técnicas Reprodutivas / veterinária Pesquisa Biomédica |
description |
Background: Ovarian transplantation in nonhuman primates (NHP) has been used as a strategy for the development of experimental models for biomedical research in the reproductive area. The prospects for application of this technique range from the restoration of female fertility to the conservation of endangered wild animals. However, studies with NHP were performed mostly focusing on the ovarian transplantation of cryopreserved tissue, in order to simulate the reality of human species, as well as aiming to obtain experimental models suitable for comparative studies. On the other hand, ovarian transplantation could be applied also in NHP species preservation. Review: According to the last census (2012-2014) of the International Union for Conservation of Nature (IUCN), currently, more than half of the 633 types of primates known around the world are in danger of disappearing forever due to the continued destruction of their natural habitat by human activities. Thus, there is an interest to expose the possible methods of ovarian preservation followed by transplantation that can be employed to promote the conservation of endangered NHP. Despite the positive results obtained with avascular autograft of fresh ovarian tissue in NHP, it is important to bring in mind the significant loss of follicles as a result of this procedure due to ischemia and reperfusion during the first days after grafting. This phenomenon leads to the production of reactive oxygen species (ROS) such as hydrogen peroxide, superoxide anion and hydroxyl radical, which are responsible by lipid peroxidation, cell membrane damage and subsequent follicular atresia. An alternative to counteract this oxidative stress consists in the application/administration of different sources of antioxidants previously or during grafting, in the grafted tissue or in the animal receiving the transplant. The most used compounds with a claimed radical scavenger activity are catalase, trolox and some vitamins. In some cases, antioxidants are combined with angiogenic factors, e.g. vascular endothelial growth factor (VEGF) to stimulate revascularization. Another option to avoid the damage caused by ischemia is the whole ovarian transplantation with vascular anastomosis. Therefore, a greater proportion of the pool of follicles survives the procedure and the complete ovary is grafted and not only tissue fragments. However, the vascular microsurgical procedure is complex and, when it is associated with cryopreservation the risks of follicular loss and tissue damage due to improper perfusion are larger. In this context, the aim of this review is to cover important concepts about ovarian transplantation and its current situation in NHP, showing its importance and its advances to reproduction, especially to preserve those endangered ones. Conclusion: Despite advances in tissue response to various applications of the ovarian tissue transplantation reported in this review, it is clear that this technique has been used with paucity as a tool for the conservation of species of PNH endangered. The need for optimization of transplantation techniques, so as to reduce the loss of the follicles during the grafting processes and revascularization, determining the ideal location for the graft, the graft longevity and where in the amount of ovarian tissue required to preserve fertility still are points to be clarified. In this sense, research is ongoing and the perspectives are positive not only to use NHP as a model for human, but also for those endangered species. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2020-02-12T18:02:09Z |
dc.date.available.fl_str_mv |
2020-02-12T18:02:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SCALERCIO, Sarah Raphaella Rocha de Azevedo et al. Transplante ovariano: Destaques na reprodução de primatas não humanos. Acta scientiae veterinariae, v. 43, n. 1315, p. 1-12, 2015. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4027 |
dc.identifier.issn.-.fl_str_mv |
1679-9216 |
identifier_str_mv |
SCALERCIO, Sarah Raphaella Rocha de Azevedo et al. Transplante ovariano: Destaques na reprodução de primatas não humanos. Acta scientiae veterinariae, v. 43, n. 1315, p. 1-12, 2015. 1679-9216 |
url |
https://patua.iec.gov.br/handle/iec/4027 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária |
publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
instname_str |
Instituto Evandro Chagas (IEC) |
instacron_str |
IEC |
institution |
IEC |
reponame_str |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
bitstream.url.fl_str_mv |
https://patua.iec.gov.br/bitstreams/fe85d3bb-f35a-4f92-b6e4-0565630cb605/download https://patua.iec.gov.br/bitstreams/2537303f-8a73-42ac-91df-63032ee40e28/download https://patua.iec.gov.br/bitstreams/20cec042-908a-4e65-8190-d58927f6a3d5/download https://patua.iec.gov.br/bitstreams/57833bda-f1e0-4958-af65-4b021083a436/download |
bitstream.checksum.fl_str_mv |
24656042a803d609d21433a5bb72bc8e 11832eea31b16df8613079d742d61793 ef6c327495f582e6a96bf3b816d72d3b c81e167bdb8a5244a23a8dc59505cf08 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC) |
repository.mail.fl_str_mv |
clariceneta@iec.gov.br || Biblioteca@iec.gov.br |
_version_ |
1787533056230293504 |