SPECTRAL PROFILE OF DRUGS AND DRUGS OF ABUSE OBTAINED BY DIFFERENT MASS ANALYZERS (FT-ICR AND LTQ): AN APPROACH TO THE ELECTROSPRAY IONIZATION SOURCE

• Autor(a) principal: Araujo dos Santos, Nayara
• Data de Publicação: 2023
• Outros Autores: Vieira Lyrio, Marcos Valério, Mendes, Campili, Queiroz dos Santos, Glaucia, Miranda Barcelos, Marcela, Cassago Nascimento, Márcia Helena, Batista de Oliveira Filpo, Rita Carolina, Roella Garcia , Robson, de Lima Silva, William Cezar, Paula Pinheiro, Marcos André, Romão, Wanderson
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Eletrônica Debates em Educação Científica e Tecnológica
• Texto Completo: https://ojs.ifes.edu.br/index.php/ric/article/view/2227
• topic: espectrometria de massas; ESI( ); FT-ICR MS; LTQ MS

Mass spectrometry is a technique that can detect, count, and characterize molecules of different compositions. Among the main components of the spectrometers are the ionization sources and mass analyzers, which have specificities of their respective manufacturers. In this sense, this work sought to analyze the spectral profile, based on analyses of pharmaceuticals for human and veterinary use, and drugs of abuse, using the same type of ionization source; electrospray ionization (ESI), positive ionization mode, coupled with Fourier transform ion cyclotron resonance (FT-ICR) and linear ion trap (LTQ) mass analyzers. Eight standards were analyzed: abamectin (C48H72O14); ceftiofur (C19H17N5O7S3); diclofenac potassium (C14H10Cl2NO2K); ivermectin (C48H74O14); lincomycin (C18H34N2O6S); moxidectin (C37H53NO8); progesterone (C21H30O2); estradiol valerate (C23H32O3); and two drug of abuse samples: cocaine (C17H21NO4) and blotter paper (containing 25I-NBOMe (C18H22INO3) and 25C-NBOMe (C18H22ClNO3)). By the data acquired, in most cases, spectra were observed with signs indicating the formation of adducts, [M + Na]+, [M + K]+, protonated molecules [M + H]+ or even dimmers, [2M+H]+, [2M + Na]+, and [2M + K]+. Thus, although the analysis with the ESI(+)FT-ICR MS equipment presents very high resolution and mass precision, the analysis by the ESI(+)LTQ MS equipment provides a fast and efficient analysis of MS/MS experiments, which contributes to confirming the structure of the detected molecule.