Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
Texto Completo: | https://doi.org/10.3892/mmr_00000120 https://repositorio.ifpa.edu.br/jspui/handle/prefix/423 |
Resumo: | Meningiomas are generally slow-growing benign tumours; however, recurrent cases are associated with a poor prognosis. As these tumours are commonly grouped according to their grade of malignancy, it is difficult to define tumourspecific alterations involved in their genesis and evolution. Genetic comparative studies of primary and recurrent tumours are important for the identification of the chromosomal, genetic and proliferative alterations that are possibly involved in the process of malignancy in this class of tumour. We performed interphase fluorescence in situ hybridization using region-specific probes comprising the genes MYCN, ERBB4, CDH1, ABR, ERBB2 and NF2 as well as AgNOR staining in a sample of primary and relapsed chordoid meningiomas. Significant differences were found in these samples regarding the genes NF2, MYCN, ABR and ERBB2. Cell proliferation levels also showed a significant difference. The results suggest the involvement of the MYCN gene in the evolution of meningiomas. |
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Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNORMeningiomaMutationMYCNNF2Tumour relapseCNPQ::CIENCIAS BIOLOGICASMeningiomas are generally slow-growing benign tumours; however, recurrent cases are associated with a poor prognosis. As these tumours are commonly grouped according to their grade of malignancy, it is difficult to define tumourspecific alterations involved in their genesis and evolution. Genetic comparative studies of primary and recurrent tumours are important for the identification of the chromosomal, genetic and proliferative alterations that are possibly involved in the process of malignancy in this class of tumour. We performed interphase fluorescence in situ hybridization using region-specific probes comprising the genes MYCN, ERBB4, CDH1, ABR, ERBB2 and NF2 as well as AgNOR staining in a sample of primary and relapsed chordoid meningiomas. Significant differences were found in these samples regarding the genes NF2, MYCN, ABR and ERBB2. Cell proliferation levels also showed a significant difference. The results suggest the involvement of the MYCN gene in the evolution of meningiomas.Universidade da AmazôniaInstituto Federal de Educação, Ciência e Tecnologia do ParáUniversidade Federal do ParáUniversidade Federal do ParáUniversidade Federal do ParáHospital Ophir LoyolaFriedrich-Schiller-Universität JenaInstituto Evandro ChagasSpandidos PublicationsGra-bretanha2023-05-11T14:41:31Z2023-05-11T14:41:31Z2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCORDEIRO, Ana Patrícia Barros; SILVA, Fábio Pacheco Estumano da, PIECZARKA, Júlio César, NAGAMACHI, Cleusa Yoshiko, ANSELMO, Nilson Praia, BRITO, José Reginaldo Nascimento, VASCONCELOS, Douglas S., LIEHR, Thomas, WEISE, Anja, de OLIVEIRA, Edvaldo Herculano Correa de. Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR. Molecular Medicine Reports, v.2 n.3, p. 449-454, mai. 2009. Disponível em:https://repositorio.ifpa.edu.br/jspui/handle/prefix/423. Acesso em:https://doi.org/10.3892/mmr_000001201791-3004https://repositorio.ifpa.edu.br/jspui/handle/prefix/423Disponível via email: repositorio.belem@ifpa.edu.brhttps://www.spandidos-publications.com/mmr/2/3/449reponame:Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA)instname:Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA)instacron:IFPAengMolecular Medicine ReportsCORDEIRO, Ana Patricia BarrosSILVA, Fábio Pacheco Estumano daPIECZARKA, Júlio CésarNAGAMACHI, Cleusa YoshikoANSELMO, Nilson PraiaBRITO, José Reginaldo NascimentoVASCONCELOS, Douglas S.LIEHR, ThomasWEISE, AnjaOLIVEIRA, Edivaldo Herculano Correa deinfo:eu-repo/semantics/openAccess2023-06-27T19:37:58Zoai:10.0.2.15:prefix/423Repositório InstitucionalPUBhttps://repositorio.ifpa.edu.br/oai/requestrepositorio@ifpa.edu.bropendoar:2023-06-27T19:37:58Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) - Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA)false |
dc.title.none.fl_str_mv |
Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR |
title |
Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR |
spellingShingle |
Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR CORDEIRO, Ana Patricia Barros Meningioma Mutation MYCN NF2 Tumour relapse CNPQ::CIENCIAS BIOLOGICAS |
title_short |
Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR |
title_full |
Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR |
title_fullStr |
Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR |
title_full_unstemmed |
Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR |
title_sort |
Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR |
author |
CORDEIRO, Ana Patricia Barros |
author_facet |
CORDEIRO, Ana Patricia Barros SILVA, Fábio Pacheco Estumano da PIECZARKA, Júlio César NAGAMACHI, Cleusa Yoshiko ANSELMO, Nilson Praia BRITO, José Reginaldo Nascimento VASCONCELOS, Douglas S. LIEHR, Thomas WEISE, Anja OLIVEIRA, Edivaldo Herculano Correa de |
author_role |
author |
author2 |
SILVA, Fábio Pacheco Estumano da PIECZARKA, Júlio César NAGAMACHI, Cleusa Yoshiko ANSELMO, Nilson Praia BRITO, José Reginaldo Nascimento VASCONCELOS, Douglas S. LIEHR, Thomas WEISE, Anja OLIVEIRA, Edivaldo Herculano Correa de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
CORDEIRO, Ana Patricia Barros SILVA, Fábio Pacheco Estumano da PIECZARKA, Júlio César NAGAMACHI, Cleusa Yoshiko ANSELMO, Nilson Praia BRITO, José Reginaldo Nascimento VASCONCELOS, Douglas S. LIEHR, Thomas WEISE, Anja OLIVEIRA, Edivaldo Herculano Correa de |
dc.subject.por.fl_str_mv |
Meningioma Mutation MYCN NF2 Tumour relapse CNPQ::CIENCIAS BIOLOGICAS |
topic |
Meningioma Mutation MYCN NF2 Tumour relapse CNPQ::CIENCIAS BIOLOGICAS |
description |
Meningiomas are generally slow-growing benign tumours; however, recurrent cases are associated with a poor prognosis. As these tumours are commonly grouped according to their grade of malignancy, it is difficult to define tumourspecific alterations involved in their genesis and evolution. Genetic comparative studies of primary and recurrent tumours are important for the identification of the chromosomal, genetic and proliferative alterations that are possibly involved in the process of malignancy in this class of tumour. We performed interphase fluorescence in situ hybridization using region-specific probes comprising the genes MYCN, ERBB4, CDH1, ABR, ERBB2 and NF2 as well as AgNOR staining in a sample of primary and relapsed chordoid meningiomas. Significant differences were found in these samples regarding the genes NF2, MYCN, ABR and ERBB2. Cell proliferation levels also showed a significant difference. The results suggest the involvement of the MYCN gene in the evolution of meningiomas. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 2023-05-11T14:41:31Z 2023-05-11T14:41:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
CORDEIRO, Ana Patrícia Barros; SILVA, Fábio Pacheco Estumano da, PIECZARKA, Júlio César, NAGAMACHI, Cleusa Yoshiko, ANSELMO, Nilson Praia, BRITO, José Reginaldo Nascimento, VASCONCELOS, Douglas S., LIEHR, Thomas, WEISE, Anja, de OLIVEIRA, Edvaldo Herculano Correa de. Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR. Molecular Medicine Reports, v.2 n.3, p. 449-454, mai. 2009. Disponível em:https://repositorio.ifpa.edu.br/jspui/handle/prefix/423. Acesso em: https://doi.org/10.3892/mmr_00000120 1791-3004 https://repositorio.ifpa.edu.br/jspui/handle/prefix/423 |
identifier_str_mv |
CORDEIRO, Ana Patrícia Barros; SILVA, Fábio Pacheco Estumano da, PIECZARKA, Júlio César, NAGAMACHI, Cleusa Yoshiko, ANSELMO, Nilson Praia, BRITO, José Reginaldo Nascimento, VASCONCELOS, Douglas S., LIEHR, Thomas, WEISE, Anja, de OLIVEIRA, Edvaldo Herculano Correa de. Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR. Molecular Medicine Reports, v.2 n.3, p. 449-454, mai. 2009. Disponível em:https://repositorio.ifpa.edu.br/jspui/handle/prefix/423. Acesso em: 1791-3004 |
url |
https://doi.org/10.3892/mmr_00000120 https://repositorio.ifpa.edu.br/jspui/handle/prefix/423 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecular Medicine Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Spandidos Publications Gra-bretanha |
publisher.none.fl_str_mv |
Spandidos Publications Gra-bretanha |
dc.source.none.fl_str_mv |
Disponível via email: repositorio.belem@ifpa.edu.br https://www.spandidos-publications.com/mmr/2/3/449 reponame:Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) instname:Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) instacron:IFPA |
instname_str |
Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
instacron_str |
IFPA |
institution |
IFPA |
reponame_str |
Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
collection |
Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
repository.name.fl_str_mv |
Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) - Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
repository.mail.fl_str_mv |
repositorio@ifpa.edu.br |
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