Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100116 |
Resumo: | Abstract Toll-like receptor 9 (TLR9) is an important component of the innate immune system and have been associated with several autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). The aim of this study was to investigate polymorphisms in TLR9 gene in a Brazilian SLE patients group and their association with clinical manifestation, particularly Jaccoud’s arthropathy (JA). We analyzed DNA samples from 204 SLE patients, having a subgroup of them presenting JA (n=24). A control group (n=133) from the same city was also included. TLR9 single nucleotide polymorphisms (SNPs) (−1237 C>T and +2848 G>A) were identified by sequencing analysis. The TLR9 gene genotype frequency was similar both in SLE patients and the control group. In the whole SLE population, an association between the homozygosis of allele C at position −1237 with psychosis and anemia (p < 0.01) was found. Likewise, the homozygosis of allele G at position +2848 was associated with a discoid rash (p < 0.05). There was no association between JA and TLR9 polymorphisms. These data show that TLR9 polymorphisms do not seem to be a predisposing factor for SLE in the Brazilian population, and that SNPs are not associated with JA. |
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Brazilian Journal of Biology |
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Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot studysystemic lupus erythematosustoll-like receptor 9polymorphismBrazilianJaccoud’s arthropathyAbstract Toll-like receptor 9 (TLR9) is an important component of the innate immune system and have been associated with several autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). The aim of this study was to investigate polymorphisms in TLR9 gene in a Brazilian SLE patients group and their association with clinical manifestation, particularly Jaccoud’s arthropathy (JA). We analyzed DNA samples from 204 SLE patients, having a subgroup of them presenting JA (n=24). A control group (n=133) from the same city was also included. TLR9 single nucleotide polymorphisms (SNPs) (−1237 C>T and +2848 G>A) were identified by sequencing analysis. The TLR9 gene genotype frequency was similar both in SLE patients and the control group. In the whole SLE population, an association between the homozygosis of allele C at position −1237 with psychosis and anemia (p < 0.01) was found. Likewise, the homozygosis of allele G at position +2848 was associated with a discoid rash (p < 0.05). There was no association between JA and TLR9 polymorphisms. These data show that TLR9 polymorphisms do not seem to be a predisposing factor for SLE in the Brazilian population, and that SNPs are not associated with JA.Instituto Internacional de Ecologia2023-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100116Brazilian Journal of Biology v.83 2023reponame:Brazilian Journal of Biologyinstname:Instituto Internacional de Ecologia (IIE)instacron:IIE10.1590/1519-6984.244123info:eu-repo/semantics/openAccessBarbosa,L. M.Santiago,M. B.Moretto,V. T.Athanazio,D.Takahashi,D.Reis,E. G.Lopes,M.Lemaire,D.Reis,M. G.eng2021-06-18T00:00:00Zoai:scielo:S1519-69842023000100116Revistahttps://www.scielo.br/j/bjb/https://old.scielo.br/oai/scielo-oai.phpbjb@bjb.com.br||bjb@bjb.com.br1678-43751519-6984opendoar:2021-06-18T00:00Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)false |
dc.title.none.fl_str_mv |
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study |
title |
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study |
spellingShingle |
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study Barbosa,L. M. systemic lupus erythematosus toll-like receptor 9 polymorphism Brazilian Jaccoud’s arthropathy |
title_short |
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study |
title_full |
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study |
title_fullStr |
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study |
title_full_unstemmed |
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study |
title_sort |
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study |
author |
Barbosa,L. M. |
author_facet |
Barbosa,L. M. Santiago,M. B. Moretto,V. T. Athanazio,D. Takahashi,D. Reis,E. G. Lopes,M. Lemaire,D. Reis,M. G. |
author_role |
author |
author2 |
Santiago,M. B. Moretto,V. T. Athanazio,D. Takahashi,D. Reis,E. G. Lopes,M. Lemaire,D. Reis,M. G. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Barbosa,L. M. Santiago,M. B. Moretto,V. T. Athanazio,D. Takahashi,D. Reis,E. G. Lopes,M. Lemaire,D. Reis,M. G. |
dc.subject.por.fl_str_mv |
systemic lupus erythematosus toll-like receptor 9 polymorphism Brazilian Jaccoud’s arthropathy |
topic |
systemic lupus erythematosus toll-like receptor 9 polymorphism Brazilian Jaccoud’s arthropathy |
description |
Abstract Toll-like receptor 9 (TLR9) is an important component of the innate immune system and have been associated with several autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). The aim of this study was to investigate polymorphisms in TLR9 gene in a Brazilian SLE patients group and their association with clinical manifestation, particularly Jaccoud’s arthropathy (JA). We analyzed DNA samples from 204 SLE patients, having a subgroup of them presenting JA (n=24). A control group (n=133) from the same city was also included. TLR9 single nucleotide polymorphisms (SNPs) (−1237 C>T and +2848 G>A) were identified by sequencing analysis. The TLR9 gene genotype frequency was similar both in SLE patients and the control group. In the whole SLE population, an association between the homozygosis of allele C at position −1237 with psychosis and anemia (p < 0.01) was found. Likewise, the homozygosis of allele G at position +2848 was associated with a discoid rash (p < 0.05). There was no association between JA and TLR9 polymorphisms. These data show that TLR9 polymorphisms do not seem to be a predisposing factor for SLE in the Brazilian population, and that SNPs are not associated with JA. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100116 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100116 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1519-6984.244123 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Internacional de Ecologia |
publisher.none.fl_str_mv |
Instituto Internacional de Ecologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Biology v.83 2023 reponame:Brazilian Journal of Biology instname:Instituto Internacional de Ecologia (IIE) instacron:IIE |
instname_str |
Instituto Internacional de Ecologia (IIE) |
instacron_str |
IIE |
institution |
IIE |
reponame_str |
Brazilian Journal of Biology |
collection |
Brazilian Journal of Biology |
repository.name.fl_str_mv |
Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE) |
repository.mail.fl_str_mv |
bjb@bjb.com.br||bjb@bjb.com.br |
_version_ |
1752129889720336384 |