Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100409 |
Resumo: | Abstract Alzheimer’s disease is a neurodegenerative condition that causes changes in memory and cognition, in addition to behavioral disorders, and most commonly affects the elderly. Several studies in the literature have presented therapeutic measures in an attempt to interfere with the pathogenic mechanisms of the disease and to mitigate its clinical manifestations. Some factors, such as excitotoxicity, cholinergic dysfunctions, oxidative stress, tau protein hyperphosphorylation, changes in amyloid-beta peptide metabolism, herpes viruses, apolipoprotein E, glycogen synthase kinase 3, insulin resistance, and the endocannabinoid system seem to be related to pathophysiology of Alzheimer’s disease. Given this, a literature review was carried out to address the molecular mechanisms associated with the pathophysiological hypotheses previously mentioned, aiming to better understanding their underlying causes and contributing to possible pharmacological strategies about treatment of the disease. |
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Hypothesis on ontogenesis and pathophysiology of Alzheimer’s diseaseAlzheimer diseaseOxidative stressAmyloid beta-peptidesTau proteinsApolipoprotein E4Glycogen synthase kinase 3Cyclic AMP response element-binding proteinDiabetes mellitus type 3EndocannabinoidsInsulin resistanceAbstract Alzheimer’s disease is a neurodegenerative condition that causes changes in memory and cognition, in addition to behavioral disorders, and most commonly affects the elderly. Several studies in the literature have presented therapeutic measures in an attempt to interfere with the pathogenic mechanisms of the disease and to mitigate its clinical manifestations. Some factors, such as excitotoxicity, cholinergic dysfunctions, oxidative stress, tau protein hyperphosphorylation, changes in amyloid-beta peptide metabolism, herpes viruses, apolipoprotein E, glycogen synthase kinase 3, insulin resistance, and the endocannabinoid system seem to be related to pathophysiology of Alzheimer’s disease. Given this, a literature review was carried out to address the molecular mechanisms associated with the pathophysiological hypotheses previously mentioned, aiming to better understanding their underlying causes and contributing to possible pharmacological strategies about treatment of the disease.Instituto Israelita de Ensino e Pesquisa Albert Einstein2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100409einstein (São Paulo) v.20 2022reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2022rw0170info:eu-repo/semantics/openAccessSchwab,Eduarda Dal PisolQueiroz,RuliamFiebrantz,Anne Karine BosettoBastos,MuriloBonini,Juliana SartoriSilva,Weber Cláudio Francisco Nunes daeng2022-11-22T00:00:00Zoai:scielo:S1679-45082022000100409Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2022-11-22T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease |
title |
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease |
spellingShingle |
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease Schwab,Eduarda Dal Pisol Alzheimer disease Oxidative stress Amyloid beta-peptides Tau proteins Apolipoprotein E4 Glycogen synthase kinase 3 Cyclic AMP response element-binding protein Diabetes mellitus type 3 Endocannabinoids Insulin resistance |
title_short |
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease |
title_full |
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease |
title_fullStr |
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease |
title_full_unstemmed |
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease |
title_sort |
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease |
author |
Schwab,Eduarda Dal Pisol |
author_facet |
Schwab,Eduarda Dal Pisol Queiroz,Ruliam Fiebrantz,Anne Karine Bosetto Bastos,Murilo Bonini,Juliana Sartori Silva,Weber Cláudio Francisco Nunes da |
author_role |
author |
author2 |
Queiroz,Ruliam Fiebrantz,Anne Karine Bosetto Bastos,Murilo Bonini,Juliana Sartori Silva,Weber Cláudio Francisco Nunes da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Schwab,Eduarda Dal Pisol Queiroz,Ruliam Fiebrantz,Anne Karine Bosetto Bastos,Murilo Bonini,Juliana Sartori Silva,Weber Cláudio Francisco Nunes da |
dc.subject.por.fl_str_mv |
Alzheimer disease Oxidative stress Amyloid beta-peptides Tau proteins Apolipoprotein E4 Glycogen synthase kinase 3 Cyclic AMP response element-binding protein Diabetes mellitus type 3 Endocannabinoids Insulin resistance |
topic |
Alzheimer disease Oxidative stress Amyloid beta-peptides Tau proteins Apolipoprotein E4 Glycogen synthase kinase 3 Cyclic AMP response element-binding protein Diabetes mellitus type 3 Endocannabinoids Insulin resistance |
description |
Abstract Alzheimer’s disease is a neurodegenerative condition that causes changes in memory and cognition, in addition to behavioral disorders, and most commonly affects the elderly. Several studies in the literature have presented therapeutic measures in an attempt to interfere with the pathogenic mechanisms of the disease and to mitigate its clinical manifestations. Some factors, such as excitotoxicity, cholinergic dysfunctions, oxidative stress, tau protein hyperphosphorylation, changes in amyloid-beta peptide metabolism, herpes viruses, apolipoprotein E, glycogen synthase kinase 3, insulin resistance, and the endocannabinoid system seem to be related to pathophysiology of Alzheimer’s disease. Given this, a literature review was carried out to address the molecular mechanisms associated with the pathophysiological hypotheses previously mentioned, aiming to better understanding their underlying causes and contributing to possible pharmacological strategies about treatment of the disease. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100409 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100409 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.31744/einstein_journal/2022rw0170 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.20 2022 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129911289544704 |