II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies

• Autor(a) principal: Goudouris,Ekaterini Simões
• Data de Publicação: 2017
• Outros Autores: Silva,Almerinda Maria do Rego, Ouricuri,Aluce Loureiro, Grumach,Anete Sevciovic, Condino-Neto,Antonio, Costa-Carvalho,Beatriz Tavares, Prando,Carolina Cardoso de Mello, Kokron,Cristina Maria, Vasconcelos,Dewton de Moraes, Tavares,Fabíola Scancetti, Silva Segundo,Gesmar Rodrigues, Barreto,Irma Cecília Douglas Paes, Dorna,Mayra de Barros, Barros,Myrthes Anna Maragna Toledo, Forte,Wilma Carvalho Neves
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Einstein (São Paulo)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100002
• topic: Immune system diseases; Immunoglobulins; Immunoglobulins, intravenous; Immunologic deficiency syndromes; Immunization, passive

ABSTRACT In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published in 2010. The document presents new knowledge about the indications and efficacy of immunoglobulin therapy in primary immunodeficiencies, relevant production-related aspects, mode of use (routes of administration, pharmacokinetics, doses and intervals), adverse events (major, prevention, treatment and reporting), patient monitoring, presentations available and how to have access to this therapeutic resource in Brazil.