Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000400206 |
Resumo: | ABSTRACT Objective To analyze suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups. Methods A descriptive study of drugs with pediatric indication included in a retrospective cohort of new drugs registered in Brazil. The evaluation of drug suitability for the pediatric age group was performed using the following criteria: suitability of dosage form and capacity to deliver the recommended dose. The drugs were considered adequate for the pediatric age groups when they met both criteria. The statistical analysis included calculation of frequencies and proportions. Results Suitability due to the drug capacity to deliver the recommended dose was greater than 80% across all age groups. Regarding suitability of the dosage form, we identified that the older the age group, the greater suitability for pediatric use. Concerning the drugs presented in solid dosage form, we showed that half were classified as inadequate for one or more pediatric age groups to whom they were indicated. The adequacy of drugs to the pediatric age group was 64.3% for preschool children, 66.7% for full-term newborns, 66.7% for premature newborns, and over 70% for other age groups. Conclusion Drugs for children aged under 6 years were less often adequate, considering the dosage form and capacity to provide the recommended dose. The availability and proportional suitability of medicines for pediatric use are greater for older age groups, according to age groups the drug is registered for. |
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Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groupsReference drugsDrug approvalDrug therapyDosage formsChildABSTRACT Objective To analyze suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups. Methods A descriptive study of drugs with pediatric indication included in a retrospective cohort of new drugs registered in Brazil. The evaluation of drug suitability for the pediatric age group was performed using the following criteria: suitability of dosage form and capacity to deliver the recommended dose. The drugs were considered adequate for the pediatric age groups when they met both criteria. The statistical analysis included calculation of frequencies and proportions. Results Suitability due to the drug capacity to deliver the recommended dose was greater than 80% across all age groups. Regarding suitability of the dosage form, we identified that the older the age group, the greater suitability for pediatric use. Concerning the drugs presented in solid dosage form, we showed that half were classified as inadequate for one or more pediatric age groups to whom they were indicated. The adequacy of drugs to the pediatric age group was 64.3% for preschool children, 66.7% for full-term newborns, 66.7% for premature newborns, and over 70% for other age groups. Conclusion Drugs for children aged under 6 years were less often adequate, considering the dosage form and capacity to provide the recommended dose. The availability and proportional suitability of medicines for pediatric use are greater for older age groups, according to age groups the drug is registered for.Instituto Israelita de Ensino e Pesquisa Albert Einstein2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000400206einstein (São Paulo) v.16 n.4 2018reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2018ao4354info:eu-repo/semantics/openAccessCastro,Jaqueline Cristina da Silveira Xavier eBotelho,Stephanie FerreiraMachado,Taisa Roberta LopesMartins,Maria Auxiliadora ParreirasVieira,Liliana BatistaReis,Adriano Max Moreiraeng2018-10-31T00:00:00Zoai:scielo:S1679-45082018000400206Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2018-10-31T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups |
title |
Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups |
spellingShingle |
Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups Castro,Jaqueline Cristina da Silveira Xavier e Reference drugs Drug approval Drug therapy Dosage forms Child |
title_short |
Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups |
title_full |
Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups |
title_fullStr |
Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups |
title_full_unstemmed |
Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups |
title_sort |
Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups |
author |
Castro,Jaqueline Cristina da Silveira Xavier e |
author_facet |
Castro,Jaqueline Cristina da Silveira Xavier e Botelho,Stephanie Ferreira Machado,Taisa Roberta Lopes Martins,Maria Auxiliadora Parreiras Vieira,Liliana Batista Reis,Adriano Max Moreira |
author_role |
author |
author2 |
Botelho,Stephanie Ferreira Machado,Taisa Roberta Lopes Martins,Maria Auxiliadora Parreiras Vieira,Liliana Batista Reis,Adriano Max Moreira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Castro,Jaqueline Cristina da Silveira Xavier e Botelho,Stephanie Ferreira Machado,Taisa Roberta Lopes Martins,Maria Auxiliadora Parreiras Vieira,Liliana Batista Reis,Adriano Max Moreira |
dc.subject.por.fl_str_mv |
Reference drugs Drug approval Drug therapy Dosage forms Child |
topic |
Reference drugs Drug approval Drug therapy Dosage forms Child |
description |
ABSTRACT Objective To analyze suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups. Methods A descriptive study of drugs with pediatric indication included in a retrospective cohort of new drugs registered in Brazil. The evaluation of drug suitability for the pediatric age group was performed using the following criteria: suitability of dosage form and capacity to deliver the recommended dose. The drugs were considered adequate for the pediatric age groups when they met both criteria. The statistical analysis included calculation of frequencies and proportions. Results Suitability due to the drug capacity to deliver the recommended dose was greater than 80% across all age groups. Regarding suitability of the dosage form, we identified that the older the age group, the greater suitability for pediatric use. Concerning the drugs presented in solid dosage form, we showed that half were classified as inadequate for one or more pediatric age groups to whom they were indicated. The adequacy of drugs to the pediatric age group was 64.3% for preschool children, 66.7% for full-term newborns, 66.7% for premature newborns, and over 70% for other age groups. Conclusion Drugs for children aged under 6 years were less often adequate, considering the dosage form and capacity to provide the recommended dose. The availability and proportional suitability of medicines for pediatric use are greater for older age groups, according to age groups the drug is registered for. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000400206 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000400206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.31744/einstein_journal/2018ao4354 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.16 n.4 2018 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129909545762816 |