Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study

Detalhes bibliográficos
Autor(a) principal: Kaliks,Rafael
Data de Publicação: 2010
Outros Autores: Guerra,Camila, Giglio,Auro Del
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000300336
Resumo: ABSTRACT Objective: To evaluate the efficacy and toxicity of the association of mitoxantrone and oral etoposide. Methods: Twelve consecutive patients with metastatic hormone-refractory prostate cancer were treated with mitoxantrone and oral etoposide. Toxicity, response rate and response duration were assessed. Results: Partial response was observed in two patients (response duration of seven and four months) and one patient had stable disease (during four months). Mitoxantrone and oral Etoposide were well tolerated and did not affect tolerability to subsequent chemotherapy. Conclusion: Mitoxantrone and oral etoposide association is an active and well-tolerated regimen in hormone-refractory prostate cancer.
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spelling Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot studyProstatic neoplasms/drug therapyNeoplasm metastasisEfficacyDrug therapy, combinationMitoxantrone/therapeutic useMitoxantrone/toxicityEtoposide/therapeutic useEtoposide/toxicidadeABSTRACT Objective: To evaluate the efficacy and toxicity of the association of mitoxantrone and oral etoposide. Methods: Twelve consecutive patients with metastatic hormone-refractory prostate cancer were treated with mitoxantrone and oral etoposide. Toxicity, response rate and response duration were assessed. Results: Partial response was observed in two patients (response duration of seven and four months) and one patient had stable disease (during four months). Mitoxantrone and oral Etoposide were well tolerated and did not affect tolerability to subsequent chemotherapy. Conclusion: Mitoxantrone and oral etoposide association is an active and well-tolerated regimen in hormone-refractory prostate cancer.Instituto Israelita de Ensino e Pesquisa Albert Einstein2010-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000300336einstein (São Paulo) v.8 n.3 2010reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082010ao1622info:eu-repo/semantics/openAccessKaliks,RafaelGuerra,CamilaGiglio,Auro Deleng2017-03-14T00:00:00Zoai:scielo:S1679-45082010000300336Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-03-14T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study
title Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study
spellingShingle Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study
Kaliks,Rafael
Prostatic neoplasms/drug therapy
Neoplasm metastasis
Efficacy
Drug therapy, combination
Mitoxantrone/therapeutic use
Mitoxantrone/toxicity
Etoposide/therapeutic use
Etoposide/toxicidade
title_short Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study
title_full Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study
title_fullStr Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study
title_full_unstemmed Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study
title_sort Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study
author Kaliks,Rafael
author_facet Kaliks,Rafael
Guerra,Camila
Giglio,Auro Del
author_role author
author2 Guerra,Camila
Giglio,Auro Del
author2_role author
author
dc.contributor.author.fl_str_mv Kaliks,Rafael
Guerra,Camila
Giglio,Auro Del
dc.subject.por.fl_str_mv Prostatic neoplasms/drug therapy
Neoplasm metastasis
Efficacy
Drug therapy, combination
Mitoxantrone/therapeutic use
Mitoxantrone/toxicity
Etoposide/therapeutic use
Etoposide/toxicidade
topic Prostatic neoplasms/drug therapy
Neoplasm metastasis
Efficacy
Drug therapy, combination
Mitoxantrone/therapeutic use
Mitoxantrone/toxicity
Etoposide/therapeutic use
Etoposide/toxicidade
description ABSTRACT Objective: To evaluate the efficacy and toxicity of the association of mitoxantrone and oral etoposide. Methods: Twelve consecutive patients with metastatic hormone-refractory prostate cancer were treated with mitoxantrone and oral etoposide. Toxicity, response rate and response duration were assessed. Results: Partial response was observed in two patients (response duration of seven and four months) and one patient had stable disease (during four months). Mitoxantrone and oral Etoposide were well tolerated and did not affect tolerability to subsequent chemotherapy. Conclusion: Mitoxantrone and oral etoposide association is an active and well-tolerated regimen in hormone-refractory prostate cancer.
publishDate 2010
dc.date.none.fl_str_mv 2010-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000300336
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000300336
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1679-45082010ao1622
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.8 n.3 2010
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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