Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil

Detalhes bibliográficos
Autor(a) principal: Oliveira,Léa Campos de
Data de Publicação: 2011
Outros Autores: Ramasawmy,Rajendranath, Borges,Jaila Dias, Marin,Maria Lucia Carnevale, Muller,Natalie Guida, Kalil,Jorge, Goldberg,Anna Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000300359
Resumo: ABSTRACT Objective: To present the frequency of single nucleotide polymorphisms of a few immune response genes in a population sample from São Paulo City (SP), Brazil. Methods: Data on allele frequencies of known polymorphisms of innate and acquired immunity genes were presented, the majority with proven impact on gene function. Data were gathered from a sample of healthy individuals, non-HLA identical siblings of bone marrow transplant recipients from the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, obtained between 1998 and 2005. The number of samples varied for each single nucleotide polymorphism analyzed by polymerase chain reaction followed by restriction enzyme cleavage. Results: Allele and genotype distribution of 41 different gene polymorphisms, mostly cytokines, but also including other immune response genes, were presented. Conclusion: We believe that the data presented here can be of great value for case-control studies, to define which polymorphisms are present in biologically relevant frequencies and to assess targets for therapeutic intervention in polygenic diseases with a component of immune and inflammatory responses.
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spelling Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, BrazilPolymorphism, geneticImmunity, innateCytokinesABSTRACT Objective: To present the frequency of single nucleotide polymorphisms of a few immune response genes in a population sample from São Paulo City (SP), Brazil. Methods: Data on allele frequencies of known polymorphisms of innate and acquired immunity genes were presented, the majority with proven impact on gene function. Data were gathered from a sample of healthy individuals, non-HLA identical siblings of bone marrow transplant recipients from the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, obtained between 1998 and 2005. The number of samples varied for each single nucleotide polymorphism analyzed by polymerase chain reaction followed by restriction enzyme cleavage. Results: Allele and genotype distribution of 41 different gene polymorphisms, mostly cytokines, but also including other immune response genes, were presented. Conclusion: We believe that the data presented here can be of great value for case-control studies, to define which polymorphisms are present in biologically relevant frequencies and to assess targets for therapeutic intervention in polygenic diseases with a component of immune and inflammatory responses.Instituto Israelita de Ensino e Pesquisa Albert Einstein2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000300359einstein (São Paulo) v.9 n.3 2011reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082011ao1866info:eu-repo/semantics/openAccessOliveira,Léa Campos deRamasawmy,RajendranathBorges,Jaila DiasMarin,Maria Lucia CarnevaleMuller,Natalie GuidaKalil,JorgeGoldberg,Anna Carlaeng2017-03-10T00:00:00Zoai:scielo:S1679-45082011000300359Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-03-10T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
title Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
spellingShingle Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
Oliveira,Léa Campos de
Polymorphism, genetic
Immunity, innate
Cytokines
title_short Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
title_full Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
title_fullStr Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
title_full_unstemmed Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
title_sort Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
author Oliveira,Léa Campos de
author_facet Oliveira,Léa Campos de
Ramasawmy,Rajendranath
Borges,Jaila Dias
Marin,Maria Lucia Carnevale
Muller,Natalie Guida
Kalil,Jorge
Goldberg,Anna Carla
author_role author
author2 Ramasawmy,Rajendranath
Borges,Jaila Dias
Marin,Maria Lucia Carnevale
Muller,Natalie Guida
Kalil,Jorge
Goldberg,Anna Carla
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Léa Campos de
Ramasawmy,Rajendranath
Borges,Jaila Dias
Marin,Maria Lucia Carnevale
Muller,Natalie Guida
Kalil,Jorge
Goldberg,Anna Carla
dc.subject.por.fl_str_mv Polymorphism, genetic
Immunity, innate
Cytokines
topic Polymorphism, genetic
Immunity, innate
Cytokines
description ABSTRACT Objective: To present the frequency of single nucleotide polymorphisms of a few immune response genes in a population sample from São Paulo City (SP), Brazil. Methods: Data on allele frequencies of known polymorphisms of innate and acquired immunity genes were presented, the majority with proven impact on gene function. Data were gathered from a sample of healthy individuals, non-HLA identical siblings of bone marrow transplant recipients from the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, obtained between 1998 and 2005. The number of samples varied for each single nucleotide polymorphism analyzed by polymerase chain reaction followed by restriction enzyme cleavage. Results: Allele and genotype distribution of 41 different gene polymorphisms, mostly cytokines, but also including other immune response genes, were presented. Conclusion: We believe that the data presented here can be of great value for case-control studies, to define which polymorphisms are present in biologically relevant frequencies and to assess targets for therapeutic intervention in polygenic diseases with a component of immune and inflammatory responses.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000300359
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000300359
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1679-45082011ao1866
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.9 n.3 2011
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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