Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000100029 |
Resumo: | ABSTRACT Objective: To study the effect of raloxifene on endometrial histopathology of menopausal women. Methods: Thirty-one patients under raloxifene treatment (60 mg/day) for a six-month period and submitted to diagnostic videohysteroscopy at the Climateric Outpatients Clinic, Department of Gynecology and Obstetrics, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, in the city of São Paulo, and at Hospital Guilherme Álvaro, in the city of Santos, from September 10th, 2003 to June 22nd, 2004, were analyzed. Guided endometrial biopsy was performed on all patients on the anterior wall, using a 3-mm or 5-mm biopsy forceps. A 3-mm or 5-mm hysteroscope was used with TV imaging by an endocamera. The results of the hysteroscopic tests were compared before and six months after the use of raloxifene. Results: The comparison between both biopsies was performed by means of the McNemar's test (marginal homogeneity test), and showed a descriptive level of 0.001 that indicates difference between the estrogen effects assessed at different moments. The estrogen effect on the endometrial tissue did not increase in any of the 31 patients analyzed. Twenty-one patients (68%) showed smaller estrogen effect in the final evaluation. Conclusions: The study showed no evidence of endometrial stimulation of raloxifene and, in fact, many women presented less estrogen effect after its use. |
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Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifeneRaloxifeneRaloxifene/antagonists & inhibitorsRaloxifene/therapeutic useEndometrium/pathologyEndometrium/drug effectsEstrogen replacement therapyPostmenopausePostmenopause/drug effectsHysteroscopyABSTRACT Objective: To study the effect of raloxifene on endometrial histopathology of menopausal women. Methods: Thirty-one patients under raloxifene treatment (60 mg/day) for a six-month period and submitted to diagnostic videohysteroscopy at the Climateric Outpatients Clinic, Department of Gynecology and Obstetrics, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, in the city of São Paulo, and at Hospital Guilherme Álvaro, in the city of Santos, from September 10th, 2003 to June 22nd, 2004, were analyzed. Guided endometrial biopsy was performed on all patients on the anterior wall, using a 3-mm or 5-mm biopsy forceps. A 3-mm or 5-mm hysteroscope was used with TV imaging by an endocamera. The results of the hysteroscopic tests were compared before and six months after the use of raloxifene. Results: The comparison between both biopsies was performed by means of the McNemar's test (marginal homogeneity test), and showed a descriptive level of 0.001 that indicates difference between the estrogen effects assessed at different moments. The estrogen effect on the endometrial tissue did not increase in any of the 31 patients analyzed. Twenty-one patients (68%) showed smaller estrogen effect in the final evaluation. Conclusions: The study showed no evidence of endometrial stimulation of raloxifene and, in fact, many women presented less estrogen effect after its use.Instituto Israelita de Ensino e Pesquisa Albert Einstein2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000100029einstein (São Paulo) v.8 n.1 2010reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082010ao1227info:eu-repo/semantics/openAccessSoares,Vanessa Maria CaetanoMartorelli Filho,BrazFernandes,Luiz Roberto AraujoLippi,Umberto Gazieng2017-03-14T00:00:00Zoai:scielo:S1679-45082010000100029Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-03-14T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene |
title |
Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene |
spellingShingle |
Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene Soares,Vanessa Maria Caetano Raloxifene Raloxifene/antagonists & inhibitors Raloxifene/therapeutic use Endometrium/pathology Endometrium/drug effects Estrogen replacement therapy Postmenopause Postmenopause/drug effects Hysteroscopy |
title_short |
Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene |
title_full |
Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene |
title_fullStr |
Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene |
title_full_unstemmed |
Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene |
title_sort |
Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene |
author |
Soares,Vanessa Maria Caetano |
author_facet |
Soares,Vanessa Maria Caetano Martorelli Filho,Braz Fernandes,Luiz Roberto Araujo Lippi,Umberto Gazi |
author_role |
author |
author2 |
Martorelli Filho,Braz Fernandes,Luiz Roberto Araujo Lippi,Umberto Gazi |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Soares,Vanessa Maria Caetano Martorelli Filho,Braz Fernandes,Luiz Roberto Araujo Lippi,Umberto Gazi |
dc.subject.por.fl_str_mv |
Raloxifene Raloxifene/antagonists & inhibitors Raloxifene/therapeutic use Endometrium/pathology Endometrium/drug effects Estrogen replacement therapy Postmenopause Postmenopause/drug effects Hysteroscopy |
topic |
Raloxifene Raloxifene/antagonists & inhibitors Raloxifene/therapeutic use Endometrium/pathology Endometrium/drug effects Estrogen replacement therapy Postmenopause Postmenopause/drug effects Hysteroscopy |
description |
ABSTRACT Objective: To study the effect of raloxifene on endometrial histopathology of menopausal women. Methods: Thirty-one patients under raloxifene treatment (60 mg/day) for a six-month period and submitted to diagnostic videohysteroscopy at the Climateric Outpatients Clinic, Department of Gynecology and Obstetrics, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, in the city of São Paulo, and at Hospital Guilherme Álvaro, in the city of Santos, from September 10th, 2003 to June 22nd, 2004, were analyzed. Guided endometrial biopsy was performed on all patients on the anterior wall, using a 3-mm or 5-mm biopsy forceps. A 3-mm or 5-mm hysteroscope was used with TV imaging by an endocamera. The results of the hysteroscopic tests were compared before and six months after the use of raloxifene. Results: The comparison between both biopsies was performed by means of the McNemar's test (marginal homogeneity test), and showed a descriptive level of 0.001 that indicates difference between the estrogen effects assessed at different moments. The estrogen effect on the endometrial tissue did not increase in any of the 31 patients analyzed. Twenty-one patients (68%) showed smaller estrogen effect in the final evaluation. Conclusions: The study showed no evidence of endometrial stimulation of raloxifene and, in fact, many women presented less estrogen effect after its use. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000100029 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000100029 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1679-45082010ao1227 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.8 n.1 2010 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129905758306304 |