Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene

Detalhes bibliográficos
Autor(a) principal: Soares,Vanessa Maria Caetano
Data de Publicação: 2010
Outros Autores: Martorelli Filho,Braz, Fernandes,Luiz Roberto Araujo, Lippi,Umberto Gazi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000100029
Resumo: ABSTRACT Objective: To study the effect of raloxifene on endometrial histopathology of menopausal women. Methods: Thirty-one patients under raloxifene treatment (60 mg/day) for a six-month period and submitted to diagnostic videohysteroscopy at the Climateric Outpatients Clinic, Department of Gynecology and Obstetrics, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, in the city of São Paulo, and at Hospital Guilherme Álvaro, in the city of Santos, from September 10th, 2003 to June 22nd, 2004, were analyzed. Guided endometrial biopsy was performed on all patients on the anterior wall, using a 3-mm or 5-mm biopsy forceps. A 3-mm or 5-mm hysteroscope was used with TV imaging by an endocamera. The results of the hysteroscopic tests were compared before and six months after the use of raloxifene. Results: The comparison between both biopsies was performed by means of the McNemar's test (marginal homogeneity test), and showed a descriptive level of 0.001 that indicates difference between the estrogen effects assessed at different moments. The estrogen effect on the endometrial tissue did not increase in any of the 31 patients analyzed. Twenty-one patients (68%) showed smaller estrogen effect in the final evaluation. Conclusions: The study showed no evidence of endometrial stimulation of raloxifene and, in fact, many women presented less estrogen effect after its use.
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spelling Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifeneRaloxifeneRaloxifene/antagonists & inhibitorsRaloxifene/therapeutic useEndometrium/pathologyEndometrium/drug effectsEstrogen replacement therapyPostmenopausePostmenopause/drug effectsHysteroscopyABSTRACT Objective: To study the effect of raloxifene on endometrial histopathology of menopausal women. Methods: Thirty-one patients under raloxifene treatment (60 mg/day) for a six-month period and submitted to diagnostic videohysteroscopy at the Climateric Outpatients Clinic, Department of Gynecology and Obstetrics, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, in the city of São Paulo, and at Hospital Guilherme Álvaro, in the city of Santos, from September 10th, 2003 to June 22nd, 2004, were analyzed. Guided endometrial biopsy was performed on all patients on the anterior wall, using a 3-mm or 5-mm biopsy forceps. A 3-mm or 5-mm hysteroscope was used with TV imaging by an endocamera. The results of the hysteroscopic tests were compared before and six months after the use of raloxifene. Results: The comparison between both biopsies was performed by means of the McNemar's test (marginal homogeneity test), and showed a descriptive level of 0.001 that indicates difference between the estrogen effects assessed at different moments. The estrogen effect on the endometrial tissue did not increase in any of the 31 patients analyzed. Twenty-one patients (68%) showed smaller estrogen effect in the final evaluation. Conclusions: The study showed no evidence of endometrial stimulation of raloxifene and, in fact, many women presented less estrogen effect after its use.Instituto Israelita de Ensino e Pesquisa Albert Einstein2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000100029einstein (São Paulo) v.8 n.1 2010reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082010ao1227info:eu-repo/semantics/openAccessSoares,Vanessa Maria CaetanoMartorelli Filho,BrazFernandes,Luiz Roberto AraujoLippi,Umberto Gazieng2017-03-14T00:00:00Zoai:scielo:S1679-45082010000100029Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-03-14T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
title Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
spellingShingle Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
Soares,Vanessa Maria Caetano
Raloxifene
Raloxifene/antagonists & inhibitors
Raloxifene/therapeutic use
Endometrium/pathology
Endometrium/drug effects
Estrogen replacement therapy
Postmenopause
Postmenopause/drug effects
Hysteroscopy
title_short Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
title_full Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
title_fullStr Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
title_full_unstemmed Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
title_sort Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene
author Soares,Vanessa Maria Caetano
author_facet Soares,Vanessa Maria Caetano
Martorelli Filho,Braz
Fernandes,Luiz Roberto Araujo
Lippi,Umberto Gazi
author_role author
author2 Martorelli Filho,Braz
Fernandes,Luiz Roberto Araujo
Lippi,Umberto Gazi
author2_role author
author
author
dc.contributor.author.fl_str_mv Soares,Vanessa Maria Caetano
Martorelli Filho,Braz
Fernandes,Luiz Roberto Araujo
Lippi,Umberto Gazi
dc.subject.por.fl_str_mv Raloxifene
Raloxifene/antagonists & inhibitors
Raloxifene/therapeutic use
Endometrium/pathology
Endometrium/drug effects
Estrogen replacement therapy
Postmenopause
Postmenopause/drug effects
Hysteroscopy
topic Raloxifene
Raloxifene/antagonists & inhibitors
Raloxifene/therapeutic use
Endometrium/pathology
Endometrium/drug effects
Estrogen replacement therapy
Postmenopause
Postmenopause/drug effects
Hysteroscopy
description ABSTRACT Objective: To study the effect of raloxifene on endometrial histopathology of menopausal women. Methods: Thirty-one patients under raloxifene treatment (60 mg/day) for a six-month period and submitted to diagnostic videohysteroscopy at the Climateric Outpatients Clinic, Department of Gynecology and Obstetrics, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, in the city of São Paulo, and at Hospital Guilherme Álvaro, in the city of Santos, from September 10th, 2003 to June 22nd, 2004, were analyzed. Guided endometrial biopsy was performed on all patients on the anterior wall, using a 3-mm or 5-mm biopsy forceps. A 3-mm or 5-mm hysteroscope was used with TV imaging by an endocamera. The results of the hysteroscopic tests were compared before and six months after the use of raloxifene. Results: The comparison between both biopsies was performed by means of the McNemar's test (marginal homogeneity test), and showed a descriptive level of 0.001 that indicates difference between the estrogen effects assessed at different moments. The estrogen effect on the endometrial tissue did not increase in any of the 31 patients analyzed. Twenty-one patients (68%) showed smaller estrogen effect in the final evaluation. Conclusions: The study showed no evidence of endometrial stimulation of raloxifene and, in fact, many women presented less estrogen effect after its use.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000100029
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082010000100029
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1679-45082010ao1227
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.8 n.1 2010
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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