Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review

Detalhes bibliográficos
Autor(a) principal: Batista,Jéssica Mauricio
Data de Publicação: 2021
Outros Autores: Martins,Maria Auxiliadora Parreiras, Bertollo,Caryne Margotto
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100502
Resumo: ABSTRACT Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum. The disease is endemic in several regions of tropical and temperate climate. The fungus presents opportunistic behavior, causing widespread infection in immunocompromised patients, resulting from complication of primary pulmonary infection, due to exogenous reinfection or reactivation of a quiescent source. In immunocompetent individuals, approximately 95% of pulmonary infections are asymptomatic. However, prolonged exposure to high amount spores may lead to acute or chronic lung infection. Due to the low amount of inoculum, primary cutaneous histoplasmosis caused by traumatic implantation is extremely rare and effectively treated with triazoles. Thus, the present study aims to report a case of primary cutaneous histoplasmosis that is difficult to treat in an immunocompetent patient, and to review the literature on the incidence of drug-resistant Histoplasma capsulatum strains in clinical practice.
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spelling Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature reviewHistoplasmosisHistoplasmaImmunocompetenceItraconazoleABSTRACT Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum. The disease is endemic in several regions of tropical and temperate climate. The fungus presents opportunistic behavior, causing widespread infection in immunocompromised patients, resulting from complication of primary pulmonary infection, due to exogenous reinfection or reactivation of a quiescent source. In immunocompetent individuals, approximately 95% of pulmonary infections are asymptomatic. However, prolonged exposure to high amount spores may lead to acute or chronic lung infection. Due to the low amount of inoculum, primary cutaneous histoplasmosis caused by traumatic implantation is extremely rare and effectively treated with triazoles. Thus, the present study aims to report a case of primary cutaneous histoplasmosis that is difficult to treat in an immunocompetent patient, and to review the literature on the incidence of drug-resistant Histoplasma capsulatum strains in clinical practice.Instituto Israelita de Ensino e Pesquisa Albert Einstein2021-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100502einstein (São Paulo) v.19 2021reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2021rc5488info:eu-repo/semantics/openAccessBatista,Jéssica MauricioMartins,Maria Auxiliadora ParreirasBertollo,Caryne Margottoeng2021-05-20T00:00:00Zoai:scielo:S1679-45082021000100502Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2021-05-20T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
title Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
spellingShingle Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
Batista,Jéssica Mauricio
Histoplasmosis
Histoplasma
Immunocompetence
Itraconazole
title_short Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
title_full Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
title_fullStr Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
title_full_unstemmed Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
title_sort Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
author Batista,Jéssica Mauricio
author_facet Batista,Jéssica Mauricio
Martins,Maria Auxiliadora Parreiras
Bertollo,Caryne Margotto
author_role author
author2 Martins,Maria Auxiliadora Parreiras
Bertollo,Caryne Margotto
author2_role author
author
dc.contributor.author.fl_str_mv Batista,Jéssica Mauricio
Martins,Maria Auxiliadora Parreiras
Bertollo,Caryne Margotto
dc.subject.por.fl_str_mv Histoplasmosis
Histoplasma
Immunocompetence
Itraconazole
topic Histoplasmosis
Histoplasma
Immunocompetence
Itraconazole
description ABSTRACT Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum. The disease is endemic in several regions of tropical and temperate climate. The fungus presents opportunistic behavior, causing widespread infection in immunocompromised patients, resulting from complication of primary pulmonary infection, due to exogenous reinfection or reactivation of a quiescent source. In immunocompetent individuals, approximately 95% of pulmonary infections are asymptomatic. However, prolonged exposure to high amount spores may lead to acute or chronic lung infection. Due to the low amount of inoculum, primary cutaneous histoplasmosis caused by traumatic implantation is extremely rare and effectively treated with triazoles. Thus, the present study aims to report a case of primary cutaneous histoplasmosis that is difficult to treat in an immunocompetent patient, and to review the literature on the incidence of drug-resistant Histoplasma capsulatum strains in clinical practice.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100502
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100502
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.31744/einstein_journal/2021rc5488
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.19 2021
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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