Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

Detalhes bibliográficos
Autor(a) principal: Andreoli,Silmara Cristiane da Silveira
Data de Publicação: 2014
Outros Autores: Gasparini,Nina Jardim, Carvalho,Gisele Pereira de, Garicochea,Bernardo, Pogue,Robert Edward, Andrade,Rosângela Vieira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256
Resumo: Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.
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spelling Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancerMicroRNAsBiological markersColorectal neoplasms/chemotherapyTreatment outcomeCombined modality therapyColorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.Instituto Israelita de Ensino e Pesquisa Albert Einstein2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256einstein (São Paulo) v.12 n.2 2014reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/S1679-45082014MD2839info:eu-repo/semantics/openAccessAndreoli,Silmara Cristiane da SilveiraGasparini,Nina JardimCarvalho,Gisele Pereira deGaricochea,BernardoPogue,Robert EdwardAndrade,Rosângela Vieira deeng2015-09-10T00:00:00Zoai:scielo:S1679-45082014000200256Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2015-09-10T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
spellingShingle Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
Andreoli,Silmara Cristiane da Silveira
MicroRNAs
Biological markers
Colorectal neoplasms/chemotherapy
Treatment outcome
Combined modality therapy
title_short Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_full Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_fullStr Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_full_unstemmed Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_sort Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
author Andreoli,Silmara Cristiane da Silveira
author_facet Andreoli,Silmara Cristiane da Silveira
Gasparini,Nina Jardim
Carvalho,Gisele Pereira de
Garicochea,Bernardo
Pogue,Robert Edward
Andrade,Rosângela Vieira de
author_role author
author2 Gasparini,Nina Jardim
Carvalho,Gisele Pereira de
Garicochea,Bernardo
Pogue,Robert Edward
Andrade,Rosângela Vieira de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Andreoli,Silmara Cristiane da Silveira
Gasparini,Nina Jardim
Carvalho,Gisele Pereira de
Garicochea,Bernardo
Pogue,Robert Edward
Andrade,Rosângela Vieira de
dc.subject.por.fl_str_mv MicroRNAs
Biological markers
Colorectal neoplasms/chemotherapy
Treatment outcome
Combined modality therapy
topic MicroRNAs
Biological markers
Colorectal neoplasms/chemotherapy
Treatment outcome
Combined modality therapy
description Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1679-45082014MD2839
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.12 n.2 2014
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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