Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200190 |
Resumo: | Objective: To analyze the outcome of patients treated with gemtuzumab ozogamycin combined with conventional therapy treated at Hospital Israelita Albert Einstein. Methods: 14 patients who had high risk features (secondary leukemia, unfavorable cytogenetics, and refractory disease) were treated with gemtuzumab ozogamycin combined with conventional therapy and their outcome was analysed by reviewing their medical records. Results: Overall response rate was 58%, with 43% achieving complete response, with a median follow-up of 11 months, event-free survival was 3 months. Eleven patients died, 6 of them due to refractory acute myeloid leukemia. Only four patients presented with grade 3 to 4 toxicities and only one patient had sinusoidal obstruction syndrome after bone marrow transplant. Conclusion: gemtuzumab ozogamycin combined with chemotherapy is a feasible treatment regimen in acute myeloid leukemia patients. However, further studies are necessary to clarify which subgroup of patients may beneft from this treatment. |
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Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemiaLeukemia, myeloid, acute/drug therapyRadiotherapyAntineoplastic agents/therapeutic useAntineoplastic combined chemotherapy protocols/therapeutic useAged Objective: To analyze the outcome of patients treated with gemtuzumab ozogamycin combined with conventional therapy treated at Hospital Israelita Albert Einstein. Methods: 14 patients who had high risk features (secondary leukemia, unfavorable cytogenetics, and refractory disease) were treated with gemtuzumab ozogamycin combined with conventional therapy and their outcome was analysed by reviewing their medical records. Results: Overall response rate was 58%, with 43% achieving complete response, with a median follow-up of 11 months, event-free survival was 3 months. Eleven patients died, 6 of them due to refractory acute myeloid leukemia. Only four patients presented with grade 3 to 4 toxicities and only one patient had sinusoidal obstruction syndrome after bone marrow transplant. Conclusion: gemtuzumab ozogamycin combined with chemotherapy is a feasible treatment regimen in acute myeloid leukemia patients. However, further studies are necessary to clarify which subgroup of patients may beneft from this treatment.Instituto Israelita de Ensino e Pesquisa Albert Einstein2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200190einstein (São Paulo) v.9 n.2 2011reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082011ao1987info:eu-repo/semantics/openAccessPerini,Guilherme FleurySantos,Fabio Pires de SouzaEsteves,IracemaNascimento,Claudia Mac-Donald Bley doRodrigues,MorganiAssis,Reijane Alves deHelman,RicardoKutner,Jose MauroRibeiro,Andreza Alice FeitosaHamerschlak,Nelsoneng2017-03-14T00:00:00Zoai:scielo:S1679-45082011000200190Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-03-14T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia |
title |
Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia |
spellingShingle |
Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia Perini,Guilherme Fleury Leukemia, myeloid, acute/drug therapy Radiotherapy Antineoplastic agents/therapeutic use Antineoplastic combined chemotherapy protocols/therapeutic use Aged |
title_short |
Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia |
title_full |
Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia |
title_fullStr |
Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia |
title_full_unstemmed |
Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia |
title_sort |
Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia |
author |
Perini,Guilherme Fleury |
author_facet |
Perini,Guilherme Fleury Santos,Fabio Pires de Souza Esteves,Iracema Nascimento,Claudia Mac-Donald Bley do Rodrigues,Morgani Assis,Reijane Alves de Helman,Ricardo Kutner,Jose Mauro Ribeiro,Andreza Alice Feitosa Hamerschlak,Nelson |
author_role |
author |
author2 |
Santos,Fabio Pires de Souza Esteves,Iracema Nascimento,Claudia Mac-Donald Bley do Rodrigues,Morgani Assis,Reijane Alves de Helman,Ricardo Kutner,Jose Mauro Ribeiro,Andreza Alice Feitosa Hamerschlak,Nelson |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Perini,Guilherme Fleury Santos,Fabio Pires de Souza Esteves,Iracema Nascimento,Claudia Mac-Donald Bley do Rodrigues,Morgani Assis,Reijane Alves de Helman,Ricardo Kutner,Jose Mauro Ribeiro,Andreza Alice Feitosa Hamerschlak,Nelson |
dc.subject.por.fl_str_mv |
Leukemia, myeloid, acute/drug therapy Radiotherapy Antineoplastic agents/therapeutic use Antineoplastic combined chemotherapy protocols/therapeutic use Aged |
topic |
Leukemia, myeloid, acute/drug therapy Radiotherapy Antineoplastic agents/therapeutic use Antineoplastic combined chemotherapy protocols/therapeutic use Aged |
description |
Objective: To analyze the outcome of patients treated with gemtuzumab ozogamycin combined with conventional therapy treated at Hospital Israelita Albert Einstein. Methods: 14 patients who had high risk features (secondary leukemia, unfavorable cytogenetics, and refractory disease) were treated with gemtuzumab ozogamycin combined with conventional therapy and their outcome was analysed by reviewing their medical records. Results: Overall response rate was 58%, with 43% achieving complete response, with a median follow-up of 11 months, event-free survival was 3 months. Eleven patients died, 6 of them due to refractory acute myeloid leukemia. Only four patients presented with grade 3 to 4 toxicities and only one patient had sinusoidal obstruction syndrome after bone marrow transplant. Conclusion: gemtuzumab ozogamycin combined with chemotherapy is a feasible treatment regimen in acute myeloid leukemia patients. However, further studies are necessary to clarify which subgroup of patients may beneft from this treatment. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200190 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200190 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1679-45082011ao1987 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.9 n.2 2011 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129906207096832 |