Biologically structured materials
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Independent Journal of Management & Production |
Texto Completo: | http://www.ijmp.jor.br/index.php/ijmp/article/view/950 |
Resumo: | Biomimetics, biomechanics, and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability. Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico). An innovative biomimetics and biomechanics approach, and a new synthetic structure providing a microenvironment, which is mechanically coherent and nutrient conducive for tissue osteoblast cell cultures used in regenerative medicine, are presented. The novel hybrid ceramic-polymeric nanocomposites are mutually investigated by finite element analysis (FEA) biomimetic modeling, anatomic reconstruction, quantitative-computed-tomography characterization, computer design of tissue scaffold. The starting base materials are a class of innovative highly bioactive hybrid ceramic-polymeric materials set-up by the proponent research group that will be used as a bioactive matrix for the preparation of in situ bio-mineralized techno- structured porous nanocomposites. This study treats biomimetics, biomechanics and tissue engineering as strongly correlated multidisciplinary fields combined to design bone tissue scaffolds. The growth, maintenance, and ossification of bone are fundamental and are regulated by the mechanical cues that are imposed by physical activities: this biomimetic/biomechanical approach will be pursued in designing the experimental procedures for in vitro scaffold mineralization and ossification. Bio-tissue mathematical modeling serves as a central repository to interface design, simulation, and tissue fabrication. Finite element computer analyses will be used to study the role of local tissue mechanics on endochondral ossification patterns, skeletal morphology and mandible thickness distributions using single and multi-phase continuum material representations of clinical cases of patients implanted with the traditional protocols. New protocols will be hypothesized for the use of the new biologically techno-structured hybrid materials. |
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Independent Journal of Management & Production |
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Biologically structured materialsBiotechnologyBioengineeringBiomaterialsBioactive scaffoldsbiomimeticsFinite Element AnalysisOsteointegrationOsteoinduction.Biomimetics, biomechanics, and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability. Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico). An innovative biomimetics and biomechanics approach, and a new synthetic structure providing a microenvironment, which is mechanically coherent and nutrient conducive for tissue osteoblast cell cultures used in regenerative medicine, are presented. The novel hybrid ceramic-polymeric nanocomposites are mutually investigated by finite element analysis (FEA) biomimetic modeling, anatomic reconstruction, quantitative-computed-tomography characterization, computer design of tissue scaffold. The starting base materials are a class of innovative highly bioactive hybrid ceramic-polymeric materials set-up by the proponent research group that will be used as a bioactive matrix for the preparation of in situ bio-mineralized techno- structured porous nanocomposites. This study treats biomimetics, biomechanics and tissue engineering as strongly correlated multidisciplinary fields combined to design bone tissue scaffolds. The growth, maintenance, and ossification of bone are fundamental and are regulated by the mechanical cues that are imposed by physical activities: this biomimetic/biomechanical approach will be pursued in designing the experimental procedures for in vitro scaffold mineralization and ossification. Bio-tissue mathematical modeling serves as a central repository to interface design, simulation, and tissue fabrication. Finite element computer analyses will be used to study the role of local tissue mechanics on endochondral ossification patterns, skeletal morphology and mandible thickness distributions using single and multi-phase continuum material representations of clinical cases of patients implanted with the traditional protocols. New protocols will be hypothesized for the use of the new biologically techno-structured hybrid materials.Independent2020-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttp://www.ijmp.jor.br/index.php/ijmp/article/view/95010.14807/ijmp.v11i4.950Independent Journal of Management & Production; Vol. 11 No. 4 (2020): Independent Journal of Management & Production; 1119-11392236-269X2236-269Xreponame:Independent Journal of Management & Productioninstname:Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP)instacron:IJM&Penghttp://www.ijmp.jor.br/index.php/ijmp/article/view/950/1376http://www.ijmp.jor.br/index.php/ijmp/article/view/950/1377Copyright (c) 2020 Raffaella Aversa, Relly Victoria Virgil Petrescu, Antonio Apicella, Florian Ion Tiberiu Petrescuinfo:eu-repo/semantics/openAccessAversa, RaffaellaPetrescu, Relly Victoria VirgilApicella, AntonioPetrescu, Florian Ion Tiberiu2020-08-01T03:31:44Zoai:www.ijmp.jor.br:article/950Revistahttp://www.ijmp.jor.br/PUBhttp://www.ijmp.jor.br/index.php/ijmp/oaiijmp@ijmp.jor.br||paulo@paulorodrigues.pro.br||2236-269X2236-269Xopendoar:2020-08-01T03:31:44Independent Journal of Management & Production - Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP)false |
dc.title.none.fl_str_mv |
Biologically structured materials |
title |
Biologically structured materials |
spellingShingle |
Biologically structured materials Aversa, Raffaella Biotechnology Bioengineering Biomaterials Bioactive scaffolds biomimetics Finite Element Analysis Osteointegration Osteoinduction. |
title_short |
Biologically structured materials |
title_full |
Biologically structured materials |
title_fullStr |
Biologically structured materials |
title_full_unstemmed |
Biologically structured materials |
title_sort |
Biologically structured materials |
author |
Aversa, Raffaella |
author_facet |
Aversa, Raffaella Petrescu, Relly Victoria Virgil Apicella, Antonio Petrescu, Florian Ion Tiberiu |
author_role |
author |
author2 |
Petrescu, Relly Victoria Virgil Apicella, Antonio Petrescu, Florian Ion Tiberiu |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Aversa, Raffaella Petrescu, Relly Victoria Virgil Apicella, Antonio Petrescu, Florian Ion Tiberiu |
dc.subject.por.fl_str_mv |
Biotechnology Bioengineering Biomaterials Bioactive scaffolds biomimetics Finite Element Analysis Osteointegration Osteoinduction. |
topic |
Biotechnology Bioengineering Biomaterials Bioactive scaffolds biomimetics Finite Element Analysis Osteointegration Osteoinduction. |
description |
Biomimetics, biomechanics, and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability. Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico). An innovative biomimetics and biomechanics approach, and a new synthetic structure providing a microenvironment, which is mechanically coherent and nutrient conducive for tissue osteoblast cell cultures used in regenerative medicine, are presented. The novel hybrid ceramic-polymeric nanocomposites are mutually investigated by finite element analysis (FEA) biomimetic modeling, anatomic reconstruction, quantitative-computed-tomography characterization, computer design of tissue scaffold. The starting base materials are a class of innovative highly bioactive hybrid ceramic-polymeric materials set-up by the proponent research group that will be used as a bioactive matrix for the preparation of in situ bio-mineralized techno- structured porous nanocomposites. This study treats biomimetics, biomechanics and tissue engineering as strongly correlated multidisciplinary fields combined to design bone tissue scaffolds. The growth, maintenance, and ossification of bone are fundamental and are regulated by the mechanical cues that are imposed by physical activities: this biomimetic/biomechanical approach will be pursued in designing the experimental procedures for in vitro scaffold mineralization and ossification. Bio-tissue mathematical modeling serves as a central repository to interface design, simulation, and tissue fabrication. Finite element computer analyses will be used to study the role of local tissue mechanics on endochondral ossification patterns, skeletal morphology and mandible thickness distributions using single and multi-phase continuum material representations of clinical cases of patients implanted with the traditional protocols. New protocols will be hypothesized for the use of the new biologically techno-structured hybrid materials. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.ijmp.jor.br/index.php/ijmp/article/view/950 10.14807/ijmp.v11i4.950 |
url |
http://www.ijmp.jor.br/index.php/ijmp/article/view/950 |
identifier_str_mv |
10.14807/ijmp.v11i4.950 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.ijmp.jor.br/index.php/ijmp/article/view/950/1376 http://www.ijmp.jor.br/index.php/ijmp/article/view/950/1377 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html |
dc.publisher.none.fl_str_mv |
Independent |
publisher.none.fl_str_mv |
Independent |
dc.source.none.fl_str_mv |
Independent Journal of Management & Production; Vol. 11 No. 4 (2020): Independent Journal of Management & Production; 1119-1139 2236-269X 2236-269X reponame:Independent Journal of Management & Production instname:Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP) instacron:IJM&P |
instname_str |
Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP) |
instacron_str |
IJM&P |
institution |
IJM&P |
reponame_str |
Independent Journal of Management & Production |
collection |
Independent Journal of Management & Production |
repository.name.fl_str_mv |
Independent Journal of Management & Production - Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP) |
repository.mail.fl_str_mv |
ijmp@ijmp.jor.br||paulo@paulorodrigues.pro.br|| |
_version_ |
1797220492242845696 |