Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Hansenologia Internationalis (Online) |
Texto Completo: | https://periodicos.saude.sp.gov.br/hansenologia/article/view/36347 |
Resumo: | In the attempt to elucidate the mechanisms that direct to the clinical forms of leprosy, HLA complex has been widely studied. Positive associations of the alelles were observed for HLA-DR2 and HLA-DR3 with the tuberculoid form (HT) and alelle HLA-DQ1 with the lepromatous form (HV). In relation to HIV, HLA-B35 and HLA-Cw4 class I alleles seem to be more strongly associated with immunological deterioration and accelerated aids progression. Class I HLA-A1, HLA-B8, HLA-B27, HLA-Cw7 and class II alleles, HLA-DR3 and HLA-DQ2 are associated with long-term nonprogressive disease. Because no literature data has described the participation of alelles HLA in individuals co-infected with leprosy and HIV, the present study aimed at evaluating in class I ( locus A,B,C) and class II (locus DR and DQ) HLA frequencies in co-infected patients, attended at the Instituto Lauroof Souza Lima, Bauru. It was possible to observe that presence of alelles associated with fast progression of aids did not infl uence the clinical spectrum of leprosy. Although HIV infection intensively affects the immune system, it seems not to lead to leprosy multibacillary forms. Since co-infection HIV/M.leprae is an important event in endemic areas for both diseases such as Brazil, more patients should be evaluated in order to increase the signifi cant of these fi ndings. |
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Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDSIdentificação dos alelos HLA de classe I e classe II em pacientes co-infectados com hanseníase e AIDSHLAhanseníaseaidsco-infecção hanseníase/ aidsleprosyaidsco-infection leprosy/aidsIn the attempt to elucidate the mechanisms that direct to the clinical forms of leprosy, HLA complex has been widely studied. Positive associations of the alelles were observed for HLA-DR2 and HLA-DR3 with the tuberculoid form (HT) and alelle HLA-DQ1 with the lepromatous form (HV). In relation to HIV, HLA-B35 and HLA-Cw4 class I alleles seem to be more strongly associated with immunological deterioration and accelerated aids progression. Class I HLA-A1, HLA-B8, HLA-B27, HLA-Cw7 and class II alleles, HLA-DR3 and HLA-DQ2 are associated with long-term nonprogressive disease. Because no literature data has described the participation of alelles HLA in individuals co-infected with leprosy and HIV, the present study aimed at evaluating in class I ( locus A,B,C) and class II (locus DR and DQ) HLA frequencies in co-infected patients, attended at the Instituto Lauroof Souza Lima, Bauru. It was possible to observe that presence of alelles associated with fast progression of aids did not infl uence the clinical spectrum of leprosy. Although HIV infection intensively affects the immune system, it seems not to lead to leprosy multibacillary forms. Since co-infection HIV/M.leprae is an important event in endemic areas for both diseases such as Brazil, more patients should be evaluated in order to increase the signifi cant of these fi ndings. O complexo HLA tem sido amplamente estudado, natentativa de elucidar os mecanismos que levam ao direcionamento da forma clínica na hanseníase. Foram observadas associações positivas dos alelos HLA-DR2 e HLA-DR3, com a forma tuberculóide (HT) e do alelo HLADQ1, com a forma virchoviana (HV). Em relação ao HIV os alelos de classe I, HLA-B35 e HLA-Cw4 parecem estar mais fortemente associados com a deterioração imunológica e com a aceleração da progressão para a aids e os alelos HLA-A1, HLA-B8, HLA-B27, HLA-Cw7 e os de classe II, HLADR3 e HLA-DQ2 com a progressão lenta da doença. Por não haver nenhum dado na literatura descrevendo a participação dos alelos HLA em indivíduos co-infectados com hanseníase e HIV, o presente estudo teve como objetivo avaliar a freqüência dos alelos HLA de Classe I e II (locus A, B, C, DR e DQ) em pacientes co-infectados, atendidos no Instituto Lauro de Souza Lima de Bauru. Foi possível observar que a presença de alelos descritos na literatura como associados com rápida progressão da aids parece não infl uenciar no espectro clínico da hanseníase. Embora a infecção pelo HIV cause profundos danos no sistema imune, não houve direcionamento para a forma virchoviana multibacilar como se poderia esperar. Estudos abrangendo maior casuística devem ser conduzidos para que os resultados sejam mais informativos uma vez que a co-infecção HIV/M.leprae é um evento importante em área endêmica para ambas as doenças.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2006-11-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3634710.47878/hi.2006.v31.36347Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 31 No. 2 (2006); 29-34Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 31 n. 2 (2006); 29-341982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/36347/34629https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Sônia Maria Usó RuizCarvalho, Claudia Peres MonteiroMarcos, Elaine Valim CamarinhaSouza, Fabiana Covolo deUra, SomeiAlmeida, Ricardo Augusto Monteiro de Barros2023-02-17T18:51:05Zoai:ojs.periodicos.saude.sp.gov.br:article/36347Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2023-02-17T18:51:05Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false |
dc.title.none.fl_str_mv |
Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS Identificação dos alelos HLA de classe I e classe II em pacientes co-infectados com hanseníase e AIDS |
title |
Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS |
spellingShingle |
Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS Silva, Sônia Maria Usó Ruiz HLA hanseníase aids co-infecção hanseníase/ aids leprosy aids co-infection leprosy/aids |
title_short |
Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS |
title_full |
Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS |
title_fullStr |
Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS |
title_full_unstemmed |
Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS |
title_sort |
Identification of HLA alleles class I and class II in co-infected patients with leprosy and AIDS |
author |
Silva, Sônia Maria Usó Ruiz |
author_facet |
Silva, Sônia Maria Usó Ruiz Carvalho, Claudia Peres Monteiro Marcos, Elaine Valim Camarinha Souza, Fabiana Covolo de Ura, Somei Almeida, Ricardo Augusto Monteiro de Barros |
author_role |
author |
author2 |
Carvalho, Claudia Peres Monteiro Marcos, Elaine Valim Camarinha Souza, Fabiana Covolo de Ura, Somei Almeida, Ricardo Augusto Monteiro de Barros |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Sônia Maria Usó Ruiz Carvalho, Claudia Peres Monteiro Marcos, Elaine Valim Camarinha Souza, Fabiana Covolo de Ura, Somei Almeida, Ricardo Augusto Monteiro de Barros |
dc.subject.por.fl_str_mv |
HLA hanseníase aids co-infecção hanseníase/ aids leprosy aids co-infection leprosy/aids |
topic |
HLA hanseníase aids co-infecção hanseníase/ aids leprosy aids co-infection leprosy/aids |
description |
In the attempt to elucidate the mechanisms that direct to the clinical forms of leprosy, HLA complex has been widely studied. Positive associations of the alelles were observed for HLA-DR2 and HLA-DR3 with the tuberculoid form (HT) and alelle HLA-DQ1 with the lepromatous form (HV). In relation to HIV, HLA-B35 and HLA-Cw4 class I alleles seem to be more strongly associated with immunological deterioration and accelerated aids progression. Class I HLA-A1, HLA-B8, HLA-B27, HLA-Cw7 and class II alleles, HLA-DR3 and HLA-DQ2 are associated with long-term nonprogressive disease. Because no literature data has described the participation of alelles HLA in individuals co-infected with leprosy and HIV, the present study aimed at evaluating in class I ( locus A,B,C) and class II (locus DR and DQ) HLA frequencies in co-infected patients, attended at the Instituto Lauroof Souza Lima, Bauru. It was possible to observe that presence of alelles associated with fast progression of aids did not infl uence the clinical spectrum of leprosy. Although HIV infection intensively affects the immune system, it seems not to lead to leprosy multibacillary forms. Since co-infection HIV/M.leprae is an important event in endemic areas for both diseases such as Brazil, more patients should be evaluated in order to increase the signifi cant of these fi ndings. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-11-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36347 10.47878/hi.2006.v31.36347 |
url |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36347 |
identifier_str_mv |
10.47878/hi.2006.v31.36347 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36347/34629 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
dc.source.none.fl_str_mv |
Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 31 No. 2 (2006); 29-34 Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 31 n. 2 (2006); 29-34 1982-5161 reponame:Hansenologia Internationalis (Online) instname:Instituto Lauro de Souza Lima (ILSL) instacron:ILSL |
instname_str |
Instituto Lauro de Souza Lima (ILSL) |
instacron_str |
ILSL |
institution |
ILSL |
reponame_str |
Hansenologia Internationalis (Online) |
collection |
Hansenologia Internationalis (Online) |
repository.name.fl_str_mv |
Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL) |
repository.mail.fl_str_mv |
hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br |
_version_ |
1796797581065453568 |