One more case of Sulfone Syndrome
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Hansenologia Internationalis (Online) |
Texto Completo: | https://periodicos.saude.sp.gov.br/hansenologia/article/view/36439 |
Resumo: | A case of a patient was reported presenting fever, pruritus, malaise, and erythroderma surrounding hypocromic macules in the anterior aspect of the trunc after the beggining of the leprosy treatment. Biopsies of lesions showed regular epitelial dermatitis and pleiomorphic lymphocitic infiltrate with intense epidermotropism and follicular involvement. Bacilli in nerves and macrophages were detected in all the biopsies. Laboratoryexamens demonstrated anaemia (erytrocytes- 3,300,000/mm3; Hb - 9,2%) and leucocitosis (20,800 leucocytes/mm3) with 40% of lymphocytes and polymorphism of these cells. These manifestations were labelled as "Sulfone Syndrom" despite the lack of other components. The authors considered atypical lymphocitosis to be the hall mark of this Syndrom and called the attention to the lymphocitic pleiomorphism in intense epidermotropism and follicular involvement observed in the histopathological examinations done. This picture disappeared in the posterior biopsies. They discussed why erythroderm did not involve hypochromic macules of leprosy and considered that an autosensitization phenomena would result in the persistency of the erythroderma even after sulfone was withdrawn. |
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One more case of Sulfone SyndromeMais um caso da síndrome da sulfonaSíndrome da SulfonaAtipia linfocitáriaHanseníaseEritrodermiaSulfone SyndromeAtipical lymphocytesLeprosyErithrodermaA case of a patient was reported presenting fever, pruritus, malaise, and erythroderma surrounding hypocromic macules in the anterior aspect of the trunc after the beggining of the leprosy treatment. Biopsies of lesions showed regular epitelial dermatitis and pleiomorphic lymphocitic infiltrate with intense epidermotropism and follicular involvement. Bacilli in nerves and macrophages were detected in all the biopsies. Laboratoryexamens demonstrated anaemia (erytrocytes- 3,300,000/mm3; Hb - 9,2%) and leucocitosis (20,800 leucocytes/mm3) with 40% of lymphocytes and polymorphism of these cells. These manifestations were labelled as "Sulfone Syndrom" despite the lack of other components. The authors considered atypical lymphocitosis to be the hall mark of this Syndrom and called the attention to the lymphocitic pleiomorphism in intense epidermotropism and follicular involvement observed in the histopathological examinations done. This picture disappeared in the posterior biopsies. They discussed why erythroderm did not involve hypochromic macules of leprosy and considered that an autosensitization phenomena would result in the persistency of the erythroderma even after sulfone was withdrawn.apresentado o caso de um paciente que iniciou tratamento de hanseníase e um mês depois apresentou febre, prurido, queda do estado geral e um quadro cutâneo de eritrodermia esfoliativa que respeitava máculas hipocrômicas no tronco anterior. Biópsias das lesões mostraram uma dermatite epitelial regular e infiltrado linfocitário pleomórfico com intenso epidermotropismo e foliculotropismo. Em todas as biópsias foramdetectados bacilos em nervos e em macrófagos. Os exames laboratoriais mostravam anemia (3.300.000 hemácias/mm3; Hb= 9,2 g%) e leucocitose (20.800 leucócitos/mm') com 40% de linfócitos e polimorfismo dessas células. Essas manifestações foram rotuladas como pertencentes à Síndrome da Sulfona apesar de faltarem seus outros componentes. Os autores consideram que a atipia linfocitária é uma característica imprescindível da síndrome e chamam também a atenção para o pleomorfismo linfocitário e o intenso epidermotropismo e foliculotropismoobservado nos exames histopatológicos que foram realizados. Eles discutem o porque da eritrodermia respeitar as máculas hipocrômicas da hanseníase e consideram que o fato do paciente continuar exibindo o quadro eritrodérmico após a retirada da sulfona, agora sem mais o infiltrado que agredia a epiderme, seria devido a um fenômeno de autossensibilização.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2000-11-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3643910.47878/hi.2000.v25.36439Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 25 No. 2 (2000); 159-162Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 25 n. 2 (2000); 159-1621982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/36439/34717https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarbosa, Angela MarquesMartins Junior, EmirFleury, Raul NegrãoOpromolla, Diltor Vladimir Araujo2023-09-27T14:18:25Zoai:ojs.periodicos.saude.sp.gov.br:article/36439Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2023-09-27T14:18:25Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false |
dc.title.none.fl_str_mv |
One more case of Sulfone Syndrome Mais um caso da síndrome da sulfona |
title |
One more case of Sulfone Syndrome |
spellingShingle |
One more case of Sulfone Syndrome Barbosa, Angela Marques Síndrome da Sulfona Atipia linfocitária Hanseníase Eritrodermia Sulfone Syndrome Atipical lymphocytes Leprosy Erithroderma |
title_short |
One more case of Sulfone Syndrome |
title_full |
One more case of Sulfone Syndrome |
title_fullStr |
One more case of Sulfone Syndrome |
title_full_unstemmed |
One more case of Sulfone Syndrome |
title_sort |
One more case of Sulfone Syndrome |
author |
Barbosa, Angela Marques |
author_facet |
Barbosa, Angela Marques Martins Junior, Emir Fleury, Raul Negrão Opromolla, Diltor Vladimir Araujo |
author_role |
author |
author2 |
Martins Junior, Emir Fleury, Raul Negrão Opromolla, Diltor Vladimir Araujo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Barbosa, Angela Marques Martins Junior, Emir Fleury, Raul Negrão Opromolla, Diltor Vladimir Araujo |
dc.subject.por.fl_str_mv |
Síndrome da Sulfona Atipia linfocitária Hanseníase Eritrodermia Sulfone Syndrome Atipical lymphocytes Leprosy Erithroderma |
topic |
Síndrome da Sulfona Atipia linfocitária Hanseníase Eritrodermia Sulfone Syndrome Atipical lymphocytes Leprosy Erithroderma |
description |
A case of a patient was reported presenting fever, pruritus, malaise, and erythroderma surrounding hypocromic macules in the anterior aspect of the trunc after the beggining of the leprosy treatment. Biopsies of lesions showed regular epitelial dermatitis and pleiomorphic lymphocitic infiltrate with intense epidermotropism and follicular involvement. Bacilli in nerves and macrophages were detected in all the biopsies. Laboratoryexamens demonstrated anaemia (erytrocytes- 3,300,000/mm3; Hb - 9,2%) and leucocitosis (20,800 leucocytes/mm3) with 40% of lymphocytes and polymorphism of these cells. These manifestations were labelled as "Sulfone Syndrom" despite the lack of other components. The authors considered atypical lymphocitosis to be the hall mark of this Syndrom and called the attention to the lymphocitic pleiomorphism in intense epidermotropism and follicular involvement observed in the histopathological examinations done. This picture disappeared in the posterior biopsies. They discussed why erythroderm did not involve hypochromic macules of leprosy and considered that an autosensitization phenomena would result in the persistency of the erythroderma even after sulfone was withdrawn. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-11-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36439 10.47878/hi.2000.v25.36439 |
url |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36439 |
identifier_str_mv |
10.47878/hi.2000.v25.36439 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36439/34717 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
dc.source.none.fl_str_mv |
Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 25 No. 2 (2000); 159-162 Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 25 n. 2 (2000); 159-162 1982-5161 reponame:Hansenologia Internationalis (Online) instname:Instituto Lauro de Souza Lima (ILSL) instacron:ILSL |
instname_str |
Instituto Lauro de Souza Lima (ILSL) |
instacron_str |
ILSL |
institution |
ILSL |
reponame_str |
Hansenologia Internationalis (Online) |
collection |
Hansenologia Internationalis (Online) |
repository.name.fl_str_mv |
Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL) |
repository.mail.fl_str_mv |
hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br |
_version_ |
1796797581432455168 |