Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients

Detalhes bibliográficos
Autor(a) principal: Souza, Fabiana Covolo de
Data de Publicação: 2010
Outros Autores: Marcos, Elaine Valim Camarinha, Ura, Somei, Nogueira, Maria Esther Sales
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Hansenologia Internationalis (Online)
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35121
Resumo: The purpose of this study was to identify the gene encoding HLA-DQ1 involved in the absence of cellular immune response in 60 Mitsuda negative leprosy patients (50LL and 10BL). The results showed the presence of HLA-DQB1*0501 in 48.30% of patients, followed by HLA-DQB1*0602 in 31.66%, both subtypes of the phenotype HLA-DQB1*01. Despite the prevalence of these alleles, we can not say that they are responsible for the lack of response to the Mitsuda antigen. We suggest further studies to confirm the results.
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spelling Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patientsLeprosyHLALeprominMycobacterium lepraeThe purpose of this study was to identify the gene encoding HLA-DQ1 involved in the absence of cellular immune response in 60 Mitsuda negative leprosy patients (50LL and 10BL). The results showed the presence of HLA-DQB1*0501 in 48.30% of patients, followed by HLA-DQB1*0602 in 31.66%, both subtypes of the phenotype HLA-DQB1*01. Despite the prevalence of these alleles, we can not say that they are responsible for the lack of response to the Mitsuda antigen. We suggest further studies to confirm the results.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2010-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35121Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 35 No. 1 (2010); 41-44Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 35 n. 1 (2010); 41-441982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLenghttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35121/33597Souza, Fabiana Covolo deMarcos, Elaine Valim CamarinhaUra, SomeiNogueira, Maria Esther Salesinfo:eu-repo/semantics/openAccess2021-06-05T23:09:57Zoai:ojs.periodicos.saude.sp.gov.br:article/35121Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2021-06-05T23:09:57Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients
title Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients
spellingShingle Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients
Souza, Fabiana Covolo de
Leprosy
HLA
Lepromin
Mycobacterium leprae
title_short Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients
title_full Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients
title_fullStr Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients
title_full_unstemmed Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients
title_sort Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients
author Souza, Fabiana Covolo de
author_facet Souza, Fabiana Covolo de
Marcos, Elaine Valim Camarinha
Ura, Somei
Nogueira, Maria Esther Sales
author_role author
author2 Marcos, Elaine Valim Camarinha
Ura, Somei
Nogueira, Maria Esther Sales
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza, Fabiana Covolo de
Marcos, Elaine Valim Camarinha
Ura, Somei
Nogueira, Maria Esther Sales
dc.subject.por.fl_str_mv Leprosy
HLA
Lepromin
Mycobacterium leprae
topic Leprosy
HLA
Lepromin
Mycobacterium leprae
description The purpose of this study was to identify the gene encoding HLA-DQ1 involved in the absence of cellular immune response in 60 Mitsuda negative leprosy patients (50LL and 10BL). The results showed the presence of HLA-DQB1*0501 in 48.30% of patients, followed by HLA-DQB1*0602 in 31.66%, both subtypes of the phenotype HLA-DQB1*01. Despite the prevalence of these alleles, we can not say that they are responsible for the lack of response to the Mitsuda antigen. We suggest further studies to confirm the results.
publishDate 2010
dc.date.none.fl_str_mv 2010-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35121
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/35121
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35121/33597
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 35 No. 1 (2010); 41-44
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 35 n. 1 (2010); 41-44
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
_version_ 1796797578813112320

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