Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana

Detalhes bibliográficos
Autor(a) principal: Dalpino, Dirceu
Data de Publicação: 1997
Outros Autores: Magna, Luiz Alberto, Opromolla , Diltor Vladimir Araújo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Hansenologia Internationalis (Online)
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36452
Resumo: Alteration in the lipid metabolism of lepromatous leprosy patients has been reported by several workers. Cardiovascular diseases, especially atherosclerosis, is frequentely referred in the anatomopathological description of lepromatous leprosy in patients from the Instituto Lauro de Souza Lima, Bauru. A subnormal level of serum total cholesterol has been observed in active lepromatous leprosy. Concerned of this fact, we determined the blood level of the protector and risk factor of the cardiovascular diseases in 82 lepromatous leprosy inpatients from that Institute and outpatients of the Healthcare Center-I Ambulatory, in Bauru. We did not confirm the low cholesterol level referred in many surveys and the obtained value for the HDL cholesterol was remarkabally different from data found among lepromatous leprosy patients in India. Fibrinolytic activity is significantly decreased in patients of lepromatous leprosy and in erythema nodosum leprosum 29,30,31,48,49. Plasminogen andapolipoprotein(a) are also genetically linked on human chromosome 6, and partial amino acid sequence of both is homologous21 . Based upon our labotatory data we suggest the importance of lipoprotein(a) in determining the cardiovascular disease risk and fibrinolytic activity alteration in lepromatous leprosy patients. Because we found highly increased blood levels of lipoprotein(a) wen present data were compared to data found in previous surveys.
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spelling Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchovianaLipoproteínaaterosclerosehanseníaseLipoproteinatherosclerosisleprosyAlteration in the lipid metabolism of lepromatous leprosy patients has been reported by several workers. Cardiovascular diseases, especially atherosclerosis, is frequentely referred in the anatomopathological description of lepromatous leprosy in patients from the Instituto Lauro de Souza Lima, Bauru. A subnormal level of serum total cholesterol has been observed in active lepromatous leprosy. Concerned of this fact, we determined the blood level of the protector and risk factor of the cardiovascular diseases in 82 lepromatous leprosy inpatients from that Institute and outpatients of the Healthcare Center-I Ambulatory, in Bauru. We did not confirm the low cholesterol level referred in many surveys and the obtained value for the HDL cholesterol was remarkabally different from data found among lepromatous leprosy patients in India. Fibrinolytic activity is significantly decreased in patients of lepromatous leprosy and in erythema nodosum leprosum 29,30,31,48,49. Plasminogen andapolipoprotein(a) are also genetically linked on human chromosome 6, and partial amino acid sequence of both is homologous21 . Based upon our labotatory data we suggest the importance of lipoprotein(a) in determining the cardiovascular disease risk and fibrinolytic activity alteration in lepromatous leprosy patients. Because we found highly increased blood levels of lipoprotein(a) wen present data were compared to data found in previous surveys.Muitos pacientes portadores de hanseníase virchoviana, após longo tempo de evolução, apresentam alterações dérmicas muito semelhantes aos xantomas e seus exames histológicos mostram numerosos macrófagos carregados de material lipídico. Esses fatos, associados a alterações humorais dos lipídeos descritas na literatura, sugerindo alterações no metabolismo dos mesmos, levou-nos a estudos, visando a estabelecer valores médios em pacientes, utilizando-se de novas determinações lipoprotêicas e de apoproteínas muito mais precisas. A Lipoproteína(a) apresentou valor médio acima de 20 mg/dl em 64,6% dos pacientes, contra 33,3% no grupo controle. O encontro de Lipoproteína(a) aumentada em pacientes portadores de hanseníase virchoviana é importante, porque existe uma comprovada relação entre esta lipoproteína e alterações vasculares tipo ateroscleróticas e distúrbios na fibrinólise.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo1997-11-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3645210.47878/hi.1997.v22.36452Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 22 No. 2 (1997); 20-30Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 22 n. 2 (1997); 20-301982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/36452/34731https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDalpino, DirceuMagna, Luiz AlbertoOpromolla , Diltor Vladimir Araújo2023-10-10T13:43:52Zoai:ojs.periodicos.saude.sp.gov.br:article/36452Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2023-10-10T13:43:52Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana
title Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana
spellingShingle Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana
Dalpino, Dirceu
Lipoproteína
aterosclerose
hanseníase
Lipoprotein
atherosclerosis
leprosy
title_short Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana
title_full Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana
title_fullStr Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana
title_full_unstemmed Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana
title_sort Avaliação dos níveis de lipídeos, lipoproteínas, apoproteínas e o papel da lipoproteína(a) no desenvolvimento de aterosclerose e alterações fibrinolíticas nos pacientes portadores de hanseníase virchoviana
author Dalpino, Dirceu
author_facet Dalpino, Dirceu
Magna, Luiz Alberto
Opromolla , Diltor Vladimir Araújo
author_role author
author2 Magna, Luiz Alberto
Opromolla , Diltor Vladimir Araújo
author2_role author
author
dc.contributor.author.fl_str_mv Dalpino, Dirceu
Magna, Luiz Alberto
Opromolla , Diltor Vladimir Araújo
dc.subject.por.fl_str_mv Lipoproteína
aterosclerose
hanseníase
Lipoprotein
atherosclerosis
leprosy
topic Lipoproteína
aterosclerose
hanseníase
Lipoprotein
atherosclerosis
leprosy
description Alteration in the lipid metabolism of lepromatous leprosy patients has been reported by several workers. Cardiovascular diseases, especially atherosclerosis, is frequentely referred in the anatomopathological description of lepromatous leprosy in patients from the Instituto Lauro de Souza Lima, Bauru. A subnormal level of serum total cholesterol has been observed in active lepromatous leprosy. Concerned of this fact, we determined the blood level of the protector and risk factor of the cardiovascular diseases in 82 lepromatous leprosy inpatients from that Institute and outpatients of the Healthcare Center-I Ambulatory, in Bauru. We did not confirm the low cholesterol level referred in many surveys and the obtained value for the HDL cholesterol was remarkabally different from data found among lepromatous leprosy patients in India. Fibrinolytic activity is significantly decreased in patients of lepromatous leprosy and in erythema nodosum leprosum 29,30,31,48,49. Plasminogen andapolipoprotein(a) are also genetically linked on human chromosome 6, and partial amino acid sequence of both is homologous21 . Based upon our labotatory data we suggest the importance of lipoprotein(a) in determining the cardiovascular disease risk and fibrinolytic activity alteration in lepromatous leprosy patients. Because we found highly increased blood levels of lipoprotein(a) wen present data were compared to data found in previous surveys.
publishDate 1997
dc.date.none.fl_str_mv 1997-11-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/36452
10.47878/hi.1997.v22.36452
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/36452
identifier_str_mv 10.47878/hi.1997.v22.36452
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/36452/34731
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 22 No. 2 (1997); 20-30
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 22 n. 2 (1997); 20-30
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
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