Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients

Detalhes bibliográficos
Autor(a) principal: Ura, Somei
Data de Publicação: 2007
Outros Autores: Diório, Suzana Madeira, Carreira, Beatriz Gomes, Lauris, José Roberto, Fleury, Raul Negrão, Barraviera, Benedito
Tipo de documento: Artigo
Idioma: por
Título da fonte: Hansenologia Internationalis (Online)
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35194
Resumo: Two therapeutic schemes in multibacillary leprosy patients were compared. The control group with 14 patients received the conventional treatment (MDT-MB). The test group with 12 patients, received the association rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg (ROM), administrated under supervision once a month, during two years. Initial evaluations include clinical, bacilloscopic and histological exams. The bacilloscopy and the biopsy were repeated at the end of first and second year of treatment. Clinical evaluations were performed monthly. All patients presented skin lesions characteristic of the lepromatous type. In the control group, the bacterial index (BI) before treatment ranged from 2 to 4.8 and in the test group it ranged from 1.6 to 4.8. Histological picture resembled active lepromatous leprosy, except one patient from the test group. At the end of the first year of treatment all patients showed clinical improvement, decreased BI and regressive histological picture. This tendency was maintained and at a final evaluation at the end of the second year all patients showed improvement on clinical, bacilloscopic and histological evaluations. Statistical analysis showed no significant differences between the groups, therefore, the two schemes were similar. In the control group all patients presented skin pigmentation after clofazimine intake. The results demonstrated that monthly administration of ROM is as efficacious and safe as MDT-MB. Besides, it doesn’t cause skin pigmentation, it can be given under supervision and can be used as alternative scheme.
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spelling Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patientsEstudo terapêutico comparando a associação de rifampicina, ofloxacina e minociclina com a associação rifampicina, clofazimina e dapsona em pacientes com hanseníase multibacilahanseníase multibacilarpoliquimioterapiaclofaziminadapsonaminociclinaofloxacinarifampicinamultibacillary leprosymultidrugtherapyclofaziminedapsoneminocyclinerifampinTwo therapeutic schemes in multibacillary leprosy patients were compared. The control group with 14 patients received the conventional treatment (MDT-MB). The test group with 12 patients, received the association rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg (ROM), administrated under supervision once a month, during two years. Initial evaluations include clinical, bacilloscopic and histological exams. The bacilloscopy and the biopsy were repeated at the end of first and second year of treatment. Clinical evaluations were performed monthly. All patients presented skin lesions characteristic of the lepromatous type. In the control group, the bacterial index (BI) before treatment ranged from 2 to 4.8 and in the test group it ranged from 1.6 to 4.8. Histological picture resembled active lepromatous leprosy, except one patient from the test group. At the end of the first year of treatment all patients showed clinical improvement, decreased BI and regressive histological picture. This tendency was maintained and at a final evaluation at the end of the second year all patients showed improvement on clinical, bacilloscopic and histological evaluations. Statistical analysis showed no significant differences between the groups, therefore, the two schemes were similar. In the control group all patients presented skin pigmentation after clofazimine intake. The results demonstrated that monthly administration of ROM is as efficacious and safe as MDT-MB. Besides, it doesn’t cause skin pigmentation, it can be given under supervision and can be used as alternative scheme.Foram comparados dois esquemas terapêuticos em pacientes com hanseníase multibacilar. O grupo controle com 14 pacientes recebeu o tratamento convencional. O grupo teste com 12 pacientes recebeu a associação de rifampicina 600 mg, ofloxacina 400 mg, e minociclina 100 mg, uma vez por mês, durante dois anos. Na avaliação inicial foram realizados exames clínicos,  baciloscópicos e histológicos. A baciloscopia e a biópsia foram repetidas no final do primeiro e segundo ano de tratamento. As avaliações clínicas realizadas mensalmente. Todos pacientes apresentavam lesões cutâneas, que os caracterizavam como virchovianos ou peri-virchovianos. No grupo controle, o índice baciloscópico antes do tratamento variou de 2 a 4,8 e no grupo teste de 1,6 a 4,8. Histologicamente apresentavam quadro de hanseníase virchoviana ativa, exceto um paciente do grupo teste. Ao final do primeiro ano de tratamento estavam todos clinicamente melhorados, o índice baciloscópico diminuído e quadro histológico regressivo. Essa tendência se mantinha e ao final do segundo ano todos estavam clinicamente, baciloscopicamente e histologicamente ainda melhores. Análise estatística mostrou não haver diferença significante entre os grupos, sendo os esquemas equivalentes. No grupo controle todos apresentaram pigmentação cutânea devido a clofazimina. Os resultados deste estudo demonstraram que o esquema com rifampicina, ofloxacina e minociclina, teve eficácia e segurança equivalente a poliquimioterapia convencional para multibacilar. Além disso, não causa pigmentação cutânea, pode ser totalmente supervisionado, podendo ser utilizado como esquema alternativo.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2007-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3519410.47878/hi.2007.v32.35194Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 32 No. 1 (2007); 57-65Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 32 n. 1 (2007); 57-651982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35194/33662Ura, SomeiDiório, Suzana MadeiraCarreira, Beatriz GomesLauris, José RobertoFleury, Raul NegrãoBarraviera, Beneditoinfo:eu-repo/semantics/openAccess2021-05-19T21:26:13Zoai:ojs.periodicos.saude.sp.gov.br:article/35194Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2021-05-19T21:26:13Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
Estudo terapêutico comparando a associação de rifampicina, ofloxacina e minociclina com a associação rifampicina, clofazimina e dapsona em pacientes com hanseníase multibacila
title Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
spellingShingle Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
Ura, Somei
hanseníase multibacilar
poliquimioterapia
clofazimina
dapsona
minociclina
ofloxacina
rifampicina
multibacillary leprosy
multidrugtherapy
clofazimine
dapsone
minocycline
rifampin
title_short Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
title_full Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
title_fullStr Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
title_full_unstemmed Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
title_sort Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
author Ura, Somei
author_facet Ura, Somei
Diório, Suzana Madeira
Carreira, Beatriz Gomes
Lauris, José Roberto
Fleury, Raul Negrão
Barraviera, Benedito
author_role author
author2 Diório, Suzana Madeira
Carreira, Beatriz Gomes
Lauris, José Roberto
Fleury, Raul Negrão
Barraviera, Benedito
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ura, Somei
Diório, Suzana Madeira
Carreira, Beatriz Gomes
Lauris, José Roberto
Fleury, Raul Negrão
Barraviera, Benedito
dc.subject.por.fl_str_mv hanseníase multibacilar
poliquimioterapia
clofazimina
dapsona
minociclina
ofloxacina
rifampicina
multibacillary leprosy
multidrugtherapy
clofazimine
dapsone
minocycline
rifampin
topic hanseníase multibacilar
poliquimioterapia
clofazimina
dapsona
minociclina
ofloxacina
rifampicina
multibacillary leprosy
multidrugtherapy
clofazimine
dapsone
minocycline
rifampin
description Two therapeutic schemes in multibacillary leprosy patients were compared. The control group with 14 patients received the conventional treatment (MDT-MB). The test group with 12 patients, received the association rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg (ROM), administrated under supervision once a month, during two years. Initial evaluations include clinical, bacilloscopic and histological exams. The bacilloscopy and the biopsy were repeated at the end of first and second year of treatment. Clinical evaluations were performed monthly. All patients presented skin lesions characteristic of the lepromatous type. In the control group, the bacterial index (BI) before treatment ranged from 2 to 4.8 and in the test group it ranged from 1.6 to 4.8. Histological picture resembled active lepromatous leprosy, except one patient from the test group. At the end of the first year of treatment all patients showed clinical improvement, decreased BI and regressive histological picture. This tendency was maintained and at a final evaluation at the end of the second year all patients showed improvement on clinical, bacilloscopic and histological evaluations. Statistical analysis showed no significant differences between the groups, therefore, the two schemes were similar. In the control group all patients presented skin pigmentation after clofazimine intake. The results demonstrated that monthly administration of ROM is as efficacious and safe as MDT-MB. Besides, it doesn’t cause skin pigmentation, it can be given under supervision and can be used as alternative scheme.
publishDate 2007
dc.date.none.fl_str_mv 2007-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35194
10.47878/hi.2007.v32.35194
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/35194
identifier_str_mv 10.47878/hi.2007.v32.35194
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35194/33662
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 32 No. 1 (2007); 57-65
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 32 n. 1 (2007); 57-65
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
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