Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Hansenologia Internationalis (Online) |
Texto Completo: | https://periodicos.saude.sp.gov.br/hansenologia/article/view/35194 |
Resumo: | Two therapeutic schemes in multibacillary leprosy patients were compared. The control group with 14 patients received the conventional treatment (MDT-MB). The test group with 12 patients, received the association rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg (ROM), administrated under supervision once a month, during two years. Initial evaluations include clinical, bacilloscopic and histological exams. The bacilloscopy and the biopsy were repeated at the end of first and second year of treatment. Clinical evaluations were performed monthly. All patients presented skin lesions characteristic of the lepromatous type. In the control group, the bacterial index (BI) before treatment ranged from 2 to 4.8 and in the test group it ranged from 1.6 to 4.8. Histological picture resembled active lepromatous leprosy, except one patient from the test group. At the end of the first year of treatment all patients showed clinical improvement, decreased BI and regressive histological picture. This tendency was maintained and at a final evaluation at the end of the second year all patients showed improvement on clinical, bacilloscopic and histological evaluations. Statistical analysis showed no significant differences between the groups, therefore, the two schemes were similar. In the control group all patients presented skin pigmentation after clofazimine intake. The results demonstrated that monthly administration of ROM is as efficacious and safe as MDT-MB. Besides, it doesn’t cause skin pigmentation, it can be given under supervision and can be used as alternative scheme. |
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Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patientsEstudo terapêutico comparando a associação de rifampicina, ofloxacina e minociclina com a associação rifampicina, clofazimina e dapsona em pacientes com hanseníase multibacilahanseníase multibacilarpoliquimioterapiaclofaziminadapsonaminociclinaofloxacinarifampicinamultibacillary leprosymultidrugtherapyclofaziminedapsoneminocyclinerifampinTwo therapeutic schemes in multibacillary leprosy patients were compared. The control group with 14 patients received the conventional treatment (MDT-MB). The test group with 12 patients, received the association rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg (ROM), administrated under supervision once a month, during two years. Initial evaluations include clinical, bacilloscopic and histological exams. The bacilloscopy and the biopsy were repeated at the end of first and second year of treatment. Clinical evaluations were performed monthly. All patients presented skin lesions characteristic of the lepromatous type. In the control group, the bacterial index (BI) before treatment ranged from 2 to 4.8 and in the test group it ranged from 1.6 to 4.8. Histological picture resembled active lepromatous leprosy, except one patient from the test group. At the end of the first year of treatment all patients showed clinical improvement, decreased BI and regressive histological picture. This tendency was maintained and at a final evaluation at the end of the second year all patients showed improvement on clinical, bacilloscopic and histological evaluations. Statistical analysis showed no significant differences between the groups, therefore, the two schemes were similar. In the control group all patients presented skin pigmentation after clofazimine intake. The results demonstrated that monthly administration of ROM is as efficacious and safe as MDT-MB. Besides, it doesn’t cause skin pigmentation, it can be given under supervision and can be used as alternative scheme.Foram comparados dois esquemas terapêuticos em pacientes com hanseníase multibacilar. O grupo controle com 14 pacientes recebeu o tratamento convencional. O grupo teste com 12 pacientes recebeu a associação de rifampicina 600 mg, ofloxacina 400 mg, e minociclina 100 mg, uma vez por mês, durante dois anos. Na avaliação inicial foram realizados exames clínicos, baciloscópicos e histológicos. A baciloscopia e a biópsia foram repetidas no final do primeiro e segundo ano de tratamento. As avaliações clínicas realizadas mensalmente. Todos pacientes apresentavam lesões cutâneas, que os caracterizavam como virchovianos ou peri-virchovianos. No grupo controle, o índice baciloscópico antes do tratamento variou de 2 a 4,8 e no grupo teste de 1,6 a 4,8. Histologicamente apresentavam quadro de hanseníase virchoviana ativa, exceto um paciente do grupo teste. Ao final do primeiro ano de tratamento estavam todos clinicamente melhorados, o índice baciloscópico diminuído e quadro histológico regressivo. Essa tendência se mantinha e ao final do segundo ano todos estavam clinicamente, baciloscopicamente e histologicamente ainda melhores. Análise estatística mostrou não haver diferença significante entre os grupos, sendo os esquemas equivalentes. No grupo controle todos apresentaram pigmentação cutânea devido a clofazimina. Os resultados deste estudo demonstraram que o esquema com rifampicina, ofloxacina e minociclina, teve eficácia e segurança equivalente a poliquimioterapia convencional para multibacilar. Além disso, não causa pigmentação cutânea, pode ser totalmente supervisionado, podendo ser utilizado como esquema alternativo.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2007-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3519410.47878/hi.2007.v32.35194Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 32 No. 1 (2007); 57-65Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 32 n. 1 (2007); 57-651982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35194/33662Ura, SomeiDiório, Suzana MadeiraCarreira, Beatriz GomesLauris, José RobertoFleury, Raul NegrãoBarraviera, Beneditoinfo:eu-repo/semantics/openAccess2021-05-19T21:26:13Zoai:ojs.periodicos.saude.sp.gov.br:article/35194Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2021-05-19T21:26:13Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false |
dc.title.none.fl_str_mv |
Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients Estudo terapêutico comparando a associação de rifampicina, ofloxacina e minociclina com a associação rifampicina, clofazimina e dapsona em pacientes com hanseníase multibacila |
title |
Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients |
spellingShingle |
Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients Ura, Somei hanseníase multibacilar poliquimioterapia clofazimina dapsona minociclina ofloxacina rifampicina multibacillary leprosy multidrugtherapy clofazimine dapsone minocycline rifampin |
title_short |
Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients |
title_full |
Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients |
title_fullStr |
Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients |
title_full_unstemmed |
Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients |
title_sort |
Therapeutic study comparing the association rifampin, ofloxacin and minocycline, with the association rifampin, clofazimine and dapsone in multibacillary leprosy patients |
author |
Ura, Somei |
author_facet |
Ura, Somei Diório, Suzana Madeira Carreira, Beatriz Gomes Lauris, José Roberto Fleury, Raul Negrão Barraviera, Benedito |
author_role |
author |
author2 |
Diório, Suzana Madeira Carreira, Beatriz Gomes Lauris, José Roberto Fleury, Raul Negrão Barraviera, Benedito |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ura, Somei Diório, Suzana Madeira Carreira, Beatriz Gomes Lauris, José Roberto Fleury, Raul Negrão Barraviera, Benedito |
dc.subject.por.fl_str_mv |
hanseníase multibacilar poliquimioterapia clofazimina dapsona minociclina ofloxacina rifampicina multibacillary leprosy multidrugtherapy clofazimine dapsone minocycline rifampin |
topic |
hanseníase multibacilar poliquimioterapia clofazimina dapsona minociclina ofloxacina rifampicina multibacillary leprosy multidrugtherapy clofazimine dapsone minocycline rifampin |
description |
Two therapeutic schemes in multibacillary leprosy patients were compared. The control group with 14 patients received the conventional treatment (MDT-MB). The test group with 12 patients, received the association rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg (ROM), administrated under supervision once a month, during two years. Initial evaluations include clinical, bacilloscopic and histological exams. The bacilloscopy and the biopsy were repeated at the end of first and second year of treatment. Clinical evaluations were performed monthly. All patients presented skin lesions characteristic of the lepromatous type. In the control group, the bacterial index (BI) before treatment ranged from 2 to 4.8 and in the test group it ranged from 1.6 to 4.8. Histological picture resembled active lepromatous leprosy, except one patient from the test group. At the end of the first year of treatment all patients showed clinical improvement, decreased BI and regressive histological picture. This tendency was maintained and at a final evaluation at the end of the second year all patients showed improvement on clinical, bacilloscopic and histological evaluations. Statistical analysis showed no significant differences between the groups, therefore, the two schemes were similar. In the control group all patients presented skin pigmentation after clofazimine intake. The results demonstrated that monthly administration of ROM is as efficacious and safe as MDT-MB. Besides, it doesn’t cause skin pigmentation, it can be given under supervision and can be used as alternative scheme. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-06-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35194 10.47878/hi.2007.v32.35194 |
url |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35194 |
identifier_str_mv |
10.47878/hi.2007.v32.35194 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35194/33662 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
dc.source.none.fl_str_mv |
Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 32 No. 1 (2007); 57-65 Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 32 n. 1 (2007); 57-65 1982-5161 reponame:Hansenologia Internationalis (Online) instname:Instituto Lauro de Souza Lima (ILSL) instacron:ILSL |
instname_str |
Instituto Lauro de Souza Lima (ILSL) |
instacron_str |
ILSL |
institution |
ILSL |
reponame_str |
Hansenologia Internationalis (Online) |
collection |
Hansenologia Internationalis (Online) |
repository.name.fl_str_mv |
Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL) |
repository.mail.fl_str_mv |
hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br |
_version_ |
1796797578881269760 |