Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report

Detalhes bibliográficos
Autor(a) principal: Souza,Alex Sandro Rolland
Data de Publicação: 2016
Outros Autores: Cordeiro,Marli Tenorio, Meneses,Jucile do Amaral, Honorato,Emanuele, Araujo Júnior,Edward, Castanha,Priscila Mayrelle da Silva, Caiado,Bruna Varginha Ramos, Faquini,Silvia de Lourdes Loreto, Santos Neto,Orlando Gomes, Schettini,Juliana Araújo de Carvalho, Mello,Luisa Medeiros de, Ishigami,Ana Catarina, Dhalia,Rafael
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista Brasileira de Saúde Materno Infantil (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000400467
Resumo: Abstract Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila-tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated.
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spelling Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case reportMicrocephalyArbovirus infectionsArthrogryposisPrenatal ultrasoundRespiratory paralysisAbstract Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila-tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated.Instituto de Medicina Integral Prof. Fernando Figueira2016-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000400467Revista Brasileira de Saúde Materno Infantil v.16 n.4 2016reponame:Revista Brasileira de Saúde Materno Infantil (Online)instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)instacron:IMIPFF10.1590/1806-93042016000400007info:eu-repo/semantics/openAccessSouza,Alex Sandro RollandCordeiro,Marli TenorioMeneses,Jucile do AmaralHonorato,EmanueleAraujo Júnior,EdwardCastanha,Priscila Mayrelle da SilvaCaiado,Bruna Varginha RamosFaquini,Silvia de Lourdes LoretoSantos Neto,Orlando GomesSchettini,Juliana Araújo de CarvalhoMello,Luisa Medeiros deIshigami,Ana CatarinaDhalia,Rafaeleng2017-01-13T00:00:00Zoai:scielo:S1519-38292016000400467Revistahttp://www.scielo.br/rbsmihttps://old.scielo.br/oai/scielo-oai.php||revista@imip.org.br1806-93041519-3829opendoar:2017-01-13T00:00Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)false
dc.title.none.fl_str_mv Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
title Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
spellingShingle Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
Souza,Alex Sandro Rolland
Microcephaly
Arbovirus infections
Arthrogryposis
Prenatal ultrasound
Respiratory paralysis
title_short Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
title_full Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
title_fullStr Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
title_full_unstemmed Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
title_sort Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
author Souza,Alex Sandro Rolland
author_facet Souza,Alex Sandro Rolland
Cordeiro,Marli Tenorio
Meneses,Jucile do Amaral
Honorato,Emanuele
Araujo Júnior,Edward
Castanha,Priscila Mayrelle da Silva
Caiado,Bruna Varginha Ramos
Faquini,Silvia de Lourdes Loreto
Santos Neto,Orlando Gomes
Schettini,Juliana Araújo de Carvalho
Mello,Luisa Medeiros de
Ishigami,Ana Catarina
Dhalia,Rafael
author_role author
author2 Cordeiro,Marli Tenorio
Meneses,Jucile do Amaral
Honorato,Emanuele
Araujo Júnior,Edward
Castanha,Priscila Mayrelle da Silva
Caiado,Bruna Varginha Ramos
Faquini,Silvia de Lourdes Loreto
Santos Neto,Orlando Gomes
Schettini,Juliana Araújo de Carvalho
Mello,Luisa Medeiros de
Ishigami,Ana Catarina
Dhalia,Rafael
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza,Alex Sandro Rolland
Cordeiro,Marli Tenorio
Meneses,Jucile do Amaral
Honorato,Emanuele
Araujo Júnior,Edward
Castanha,Priscila Mayrelle da Silva
Caiado,Bruna Varginha Ramos
Faquini,Silvia de Lourdes Loreto
Santos Neto,Orlando Gomes
Schettini,Juliana Araújo de Carvalho
Mello,Luisa Medeiros de
Ishigami,Ana Catarina
Dhalia,Rafael
dc.subject.por.fl_str_mv Microcephaly
Arbovirus infections
Arthrogryposis
Prenatal ultrasound
Respiratory paralysis
topic Microcephaly
Arbovirus infections
Arthrogryposis
Prenatal ultrasound
Respiratory paralysis
description Abstract Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila-tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000400467
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000400467
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-93042016000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Medicina Integral Prof. Fernando Figueira
publisher.none.fl_str_mv Instituto de Medicina Integral Prof. Fernando Figueira
dc.source.none.fl_str_mv Revista Brasileira de Saúde Materno Infantil v.16 n.4 2016
reponame:Revista Brasileira de Saúde Materno Infantil (Online)
instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
instacron:IMIPFF
instname_str Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
instacron_str IMIPFF
institution IMIPFF
reponame_str Revista Brasileira de Saúde Materno Infantil (Online)
collection Revista Brasileira de Saúde Materno Infantil (Online)
repository.name.fl_str_mv Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
repository.mail.fl_str_mv ||revista@imip.org.br
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