Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Saúde Materno Infantil (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000400467 |
Resumo: | Abstract Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila-tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated. |
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Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case reportMicrocephalyArbovirus infectionsArthrogryposisPrenatal ultrasoundRespiratory paralysisAbstract Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila-tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated.Instituto de Medicina Integral Prof. Fernando Figueira2016-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000400467Revista Brasileira de Saúde Materno Infantil v.16 n.4 2016reponame:Revista Brasileira de Saúde Materno Infantil (Online)instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)instacron:IMIPFF10.1590/1806-93042016000400007info:eu-repo/semantics/openAccessSouza,Alex Sandro RollandCordeiro,Marli TenorioMeneses,Jucile do AmaralHonorato,EmanueleAraujo Júnior,EdwardCastanha,Priscila Mayrelle da SilvaCaiado,Bruna Varginha RamosFaquini,Silvia de Lourdes LoretoSantos Neto,Orlando GomesSchettini,Juliana Araújo de CarvalhoMello,Luisa Medeiros deIshigami,Ana CatarinaDhalia,Rafaeleng2017-01-13T00:00:00Zoai:scielo:S1519-38292016000400467Revistahttp://www.scielo.br/rbsmihttps://old.scielo.br/oai/scielo-oai.php||revista@imip.org.br1806-93041519-3829opendoar:2017-01-13T00:00Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)false |
dc.title.none.fl_str_mv |
Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report |
title |
Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report |
spellingShingle |
Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report Souza,Alex Sandro Rolland Microcephaly Arbovirus infections Arthrogryposis Prenatal ultrasound Respiratory paralysis |
title_short |
Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report |
title_full |
Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report |
title_fullStr |
Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report |
title_full_unstemmed |
Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report |
title_sort |
Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report |
author |
Souza,Alex Sandro Rolland |
author_facet |
Souza,Alex Sandro Rolland Cordeiro,Marli Tenorio Meneses,Jucile do Amaral Honorato,Emanuele Araujo Júnior,Edward Castanha,Priscila Mayrelle da Silva Caiado,Bruna Varginha Ramos Faquini,Silvia de Lourdes Loreto Santos Neto,Orlando Gomes Schettini,Juliana Araújo de Carvalho Mello,Luisa Medeiros de Ishigami,Ana Catarina Dhalia,Rafael |
author_role |
author |
author2 |
Cordeiro,Marli Tenorio Meneses,Jucile do Amaral Honorato,Emanuele Araujo Júnior,Edward Castanha,Priscila Mayrelle da Silva Caiado,Bruna Varginha Ramos Faquini,Silvia de Lourdes Loreto Santos Neto,Orlando Gomes Schettini,Juliana Araújo de Carvalho Mello,Luisa Medeiros de Ishigami,Ana Catarina Dhalia,Rafael |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza,Alex Sandro Rolland Cordeiro,Marli Tenorio Meneses,Jucile do Amaral Honorato,Emanuele Araujo Júnior,Edward Castanha,Priscila Mayrelle da Silva Caiado,Bruna Varginha Ramos Faquini,Silvia de Lourdes Loreto Santos Neto,Orlando Gomes Schettini,Juliana Araújo de Carvalho Mello,Luisa Medeiros de Ishigami,Ana Catarina Dhalia,Rafael |
dc.subject.por.fl_str_mv |
Microcephaly Arbovirus infections Arthrogryposis Prenatal ultrasound Respiratory paralysis |
topic |
Microcephaly Arbovirus infections Arthrogryposis Prenatal ultrasound Respiratory paralysis |
description |
Abstract Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila-tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000400467 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000400467 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-93042016000400007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Medicina Integral Prof. Fernando Figueira |
publisher.none.fl_str_mv |
Instituto de Medicina Integral Prof. Fernando Figueira |
dc.source.none.fl_str_mv |
Revista Brasileira de Saúde Materno Infantil v.16 n.4 2016 reponame:Revista Brasileira de Saúde Materno Infantil (Online) instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) instacron:IMIPFF |
instname_str |
Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) |
instacron_str |
IMIPFF |
institution |
IMIPFF |
reponame_str |
Revista Brasileira de Saúde Materno Infantil (Online) |
collection |
Revista Brasileira de Saúde Materno Infantil (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) |
repository.mail.fl_str_mv |
||revista@imip.org.br |
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1752129929520087040 |