Measles vaccination: influence of age on its efficacy

Detalhes bibliográficos
Autor(a) principal: Lopes, Marta Heloísa
Data de Publicação: 1989
Outros Autores: Mendonça, João Silva de, Pannuti, Cláudio Sérgio, Albrecht, Paul, Biancalana, Maria Lúcia Neves, Mantese, Orlando César, Correa, José Fábio, Amato Neto, Vicente
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28683
Resumo: The authors compare the serologic efficacy and the clinical protection afforded by three different measles vaccination schemes in adequately nourished children in São Paulo city, Brazil. Two hundred forty two children were divided into three groups. Group A, comprising 117 children who had received the vaccine before 12 months of age and a second dose at 12 months of age or more. Group B, comprising 46 children who had received only one dose, before 12 months of age. Group C, comprising 79 children who had received only one dose, at 12 months of age or more. The geometric mean titer of antibodies in Group A was 790.1; in Group B, 251.1; and in Group C, 550.3. There was no statistically significant difference between Groups A and C. The exposure to the measles virus was probably similar in all groups, and the children in Groups A and C had similar chances of acquiring the disease after vaccination whereas in Group B the chances were higher when compared to the other two groups. The results obtained in this study favor the use, in developing countries, of a vaccination program against measles that includes an early first dose at eight months of age and revaccination after 12 months of age.
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spelling Measles vaccination: influence of age on its efficacy Vacinação contra o sarampo: influência da idade em sua eficácia Measles vaccineMeaslesChildren immunization The authors compare the serologic efficacy and the clinical protection afforded by three different measles vaccination schemes in adequately nourished children in São Paulo city, Brazil. Two hundred forty two children were divided into three groups. Group A, comprising 117 children who had received the vaccine before 12 months of age and a second dose at 12 months of age or more. Group B, comprising 46 children who had received only one dose, before 12 months of age. Group C, comprising 79 children who had received only one dose, at 12 months of age or more. The geometric mean titer of antibodies in Group A was 790.1; in Group B, 251.1; and in Group C, 550.3. There was no statistically significant difference between Groups A and C. The exposure to the measles virus was probably similar in all groups, and the children in Groups A and C had similar chances of acquiring the disease after vaccination whereas in Group B the chances were higher when compared to the other two groups. The results obtained in this study favor the use, in developing countries, of a vaccination program against measles that includes an early first dose at eight months of age and revaccination after 12 months of age. Os autores comparam a eficácia sorológica e a proteção clinica obtidas com três esquemas diferentes de vacinação contra o sarampo, em crianças eutróficas, na cidade de São Paulo, Brasil. Duzentas e quarenta e duas crianças foram divididas em três grupos. Grupo A, compreendendo 117 crianças primovacinadas antes dos 12 meses de idade e revacinadas com 12 ou mais meses de idade. Grupo B, compreendendo 46 crianças vacinadas com dose única, antes dos 12 meses de idade. Grupo C, compreendendo 79 crianças vacinadas com dose única, aos 12 ou mais meses de idade. A média geométrica do título de anticorpos no grupo A foi 790,1; no grupo B, 251,1; e no grupo C, 550,3. Não houve diferença estatisticamente significante entre os grupos A e C. A exposição ao vírus do sarampo foi provavelmente semelhante em todos os grupos. As crianças dos grupos A e C apresentaram risco de adoecimento semelhante após vacinação, enquanto que tal risco foi maior no grupo B quando comparado aos outros dois grupos. Os resultados obtidos neste estudo falam a favor do uso, em países em desenvolvimento, de um programa de vacinação contra o sarampo que inclua uma primeira dose àos oito meses de idade e revacinação após os 12 meses de idade. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1989-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28683Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 5 (1989); 322-327 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 5 (1989); 322-327 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 5 (1989); 322-327 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28683/30536Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessLopes, Marta HeloísaMendonça, João Silva dePannuti, Cláudio SérgioAlbrecht, PaulBiancalana, Maria Lúcia NevesMantese, Orlando CésarCorrea, José FábioAmato Neto, Vicente2012-07-02T01:11:06Zoai:revistas.usp.br:article/28683Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:25.927576Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Measles vaccination: influence of age on its efficacy
Vacinação contra o sarampo: influência da idade em sua eficácia
title Measles vaccination: influence of age on its efficacy
spellingShingle Measles vaccination: influence of age on its efficacy
Lopes, Marta Heloísa
Measles vaccine
Measles
Children immunization
title_short Measles vaccination: influence of age on its efficacy
title_full Measles vaccination: influence of age on its efficacy
title_fullStr Measles vaccination: influence of age on its efficacy
title_full_unstemmed Measles vaccination: influence of age on its efficacy
title_sort Measles vaccination: influence of age on its efficacy
author Lopes, Marta Heloísa
author_facet Lopes, Marta Heloísa
Mendonça, João Silva de
Pannuti, Cláudio Sérgio
Albrecht, Paul
Biancalana, Maria Lúcia Neves
Mantese, Orlando César
Correa, José Fábio
Amato Neto, Vicente
author_role author
author2 Mendonça, João Silva de
Pannuti, Cláudio Sérgio
Albrecht, Paul
Biancalana, Maria Lúcia Neves
Mantese, Orlando César
Correa, José Fábio
Amato Neto, Vicente
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Marta Heloísa
Mendonça, João Silva de
Pannuti, Cláudio Sérgio
Albrecht, Paul
Biancalana, Maria Lúcia Neves
Mantese, Orlando César
Correa, José Fábio
Amato Neto, Vicente
dc.subject.por.fl_str_mv Measles vaccine
Measles
Children immunization
topic Measles vaccine
Measles
Children immunization
description The authors compare the serologic efficacy and the clinical protection afforded by three different measles vaccination schemes in adequately nourished children in São Paulo city, Brazil. Two hundred forty two children were divided into three groups. Group A, comprising 117 children who had received the vaccine before 12 months of age and a second dose at 12 months of age or more. Group B, comprising 46 children who had received only one dose, before 12 months of age. Group C, comprising 79 children who had received only one dose, at 12 months of age or more. The geometric mean titer of antibodies in Group A was 790.1; in Group B, 251.1; and in Group C, 550.3. There was no statistically significant difference between Groups A and C. The exposure to the measles virus was probably similar in all groups, and the children in Groups A and C had similar chances of acquiring the disease after vaccination whereas in Group B the chances were higher when compared to the other two groups. The results obtained in this study favor the use, in developing countries, of a vaccination program against measles that includes an early first dose at eight months of age and revaccination after 12 months of age.
publishDate 1989
dc.date.none.fl_str_mv 1989-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28683
url https://www.revistas.usp.br/rimtsp/article/view/28683
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28683/30536
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 5 (1989); 322-327
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 5 (1989); 322-327
Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 5 (1989); 322-327
1678-9946
0036-4665
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reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
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