Measles vaccination: influence of age on its efficacy
Autor(a) principal: | |
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Data de Publicação: | 1989 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28683 |
Resumo: | The authors compare the serologic efficacy and the clinical protection afforded by three different measles vaccination schemes in adequately nourished children in São Paulo city, Brazil. Two hundred forty two children were divided into three groups. Group A, comprising 117 children who had received the vaccine before 12 months of age and a second dose at 12 months of age or more. Group B, comprising 46 children who had received only one dose, before 12 months of age. Group C, comprising 79 children who had received only one dose, at 12 months of age or more. The geometric mean titer of antibodies in Group A was 790.1; in Group B, 251.1; and in Group C, 550.3. There was no statistically significant difference between Groups A and C. The exposure to the measles virus was probably similar in all groups, and the children in Groups A and C had similar chances of acquiring the disease after vaccination whereas in Group B the chances were higher when compared to the other two groups. The results obtained in this study favor the use, in developing countries, of a vaccination program against measles that includes an early first dose at eight months of age and revaccination after 12 months of age. |
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Measles vaccination: influence of age on its efficacy Vacinação contra o sarampo: influência da idade em sua eficácia Measles vaccineMeaslesChildren immunization The authors compare the serologic efficacy and the clinical protection afforded by three different measles vaccination schemes in adequately nourished children in São Paulo city, Brazil. Two hundred forty two children were divided into three groups. Group A, comprising 117 children who had received the vaccine before 12 months of age and a second dose at 12 months of age or more. Group B, comprising 46 children who had received only one dose, before 12 months of age. Group C, comprising 79 children who had received only one dose, at 12 months of age or more. The geometric mean titer of antibodies in Group A was 790.1; in Group B, 251.1; and in Group C, 550.3. There was no statistically significant difference between Groups A and C. The exposure to the measles virus was probably similar in all groups, and the children in Groups A and C had similar chances of acquiring the disease after vaccination whereas in Group B the chances were higher when compared to the other two groups. The results obtained in this study favor the use, in developing countries, of a vaccination program against measles that includes an early first dose at eight months of age and revaccination after 12 months of age. Os autores comparam a eficácia sorológica e a proteção clinica obtidas com três esquemas diferentes de vacinação contra o sarampo, em crianças eutróficas, na cidade de São Paulo, Brasil. Duzentas e quarenta e duas crianças foram divididas em três grupos. Grupo A, compreendendo 117 crianças primovacinadas antes dos 12 meses de idade e revacinadas com 12 ou mais meses de idade. Grupo B, compreendendo 46 crianças vacinadas com dose única, antes dos 12 meses de idade. Grupo C, compreendendo 79 crianças vacinadas com dose única, aos 12 ou mais meses de idade. A média geométrica do título de anticorpos no grupo A foi 790,1; no grupo B, 251,1; e no grupo C, 550,3. Não houve diferença estatisticamente significante entre os grupos A e C. A exposição ao vírus do sarampo foi provavelmente semelhante em todos os grupos. As crianças dos grupos A e C apresentaram risco de adoecimento semelhante após vacinação, enquanto que tal risco foi maior no grupo B quando comparado aos outros dois grupos. Os resultados obtidos neste estudo falam a favor do uso, em países em desenvolvimento, de um programa de vacinação contra o sarampo que inclua uma primeira dose àos oito meses de idade e revacinação após os 12 meses de idade. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1989-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28683Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 5 (1989); 322-327 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 5 (1989); 322-327 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 5 (1989); 322-327 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28683/30536Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessLopes, Marta HeloísaMendonça, João Silva dePannuti, Cláudio SérgioAlbrecht, PaulBiancalana, Maria Lúcia NevesMantese, Orlando CésarCorrea, José FábioAmato Neto, Vicente2012-07-02T01:11:06Zoai:revistas.usp.br:article/28683Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:25.927576Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Measles vaccination: influence of age on its efficacy Vacinação contra o sarampo: influência da idade em sua eficácia |
title |
Measles vaccination: influence of age on its efficacy |
spellingShingle |
Measles vaccination: influence of age on its efficacy Lopes, Marta Heloísa Measles vaccine Measles Children immunization |
title_short |
Measles vaccination: influence of age on its efficacy |
title_full |
Measles vaccination: influence of age on its efficacy |
title_fullStr |
Measles vaccination: influence of age on its efficacy |
title_full_unstemmed |
Measles vaccination: influence of age on its efficacy |
title_sort |
Measles vaccination: influence of age on its efficacy |
author |
Lopes, Marta Heloísa |
author_facet |
Lopes, Marta Heloísa Mendonça, João Silva de Pannuti, Cláudio Sérgio Albrecht, Paul Biancalana, Maria Lúcia Neves Mantese, Orlando César Correa, José Fábio Amato Neto, Vicente |
author_role |
author |
author2 |
Mendonça, João Silva de Pannuti, Cláudio Sérgio Albrecht, Paul Biancalana, Maria Lúcia Neves Mantese, Orlando César Correa, José Fábio Amato Neto, Vicente |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lopes, Marta Heloísa Mendonça, João Silva de Pannuti, Cláudio Sérgio Albrecht, Paul Biancalana, Maria Lúcia Neves Mantese, Orlando César Correa, José Fábio Amato Neto, Vicente |
dc.subject.por.fl_str_mv |
Measles vaccine Measles Children immunization |
topic |
Measles vaccine Measles Children immunization |
description |
The authors compare the serologic efficacy and the clinical protection afforded by three different measles vaccination schemes in adequately nourished children in São Paulo city, Brazil. Two hundred forty two children were divided into three groups. Group A, comprising 117 children who had received the vaccine before 12 months of age and a second dose at 12 months of age or more. Group B, comprising 46 children who had received only one dose, before 12 months of age. Group C, comprising 79 children who had received only one dose, at 12 months of age or more. The geometric mean titer of antibodies in Group A was 790.1; in Group B, 251.1; and in Group C, 550.3. There was no statistically significant difference between Groups A and C. The exposure to the measles virus was probably similar in all groups, and the children in Groups A and C had similar chances of acquiring the disease after vaccination whereas in Group B the chances were higher when compared to the other two groups. The results obtained in this study favor the use, in developing countries, of a vaccination program against measles that includes an early first dose at eight months of age and revaccination after 12 months of age. |
publishDate |
1989 |
dc.date.none.fl_str_mv |
1989-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28683 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28683 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28683/30536 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 5 (1989); 322-327 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 5 (1989); 322-327 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 5 (1989); 322-327 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951638232203264 |