Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Bastos, Othon de Carvalho
Data de Publicação: 1984
Outros Autores: Sadigursky, Moysés, Nascimento, Maria do Desterro Soares Brandão do, Brazil, Reginaldo Peçanha, Holanda, João Carvalho de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/87338
Resumo: Wild rodents classified as Holochilus brasiliensis nanus THOMAS, 1897, were captured in Lowland Region of State of Maranhão-Brazil. Natural infection by schistosome and filaria was detected in the most of these animals. Rodents born in the Animal House of the University of Maranhão were experimentally infected with Leishmania mexicana amazonensis or Schistosoma mansoni. Pathological aspects of leishmaniasis in these animals were found similar to that found in hamsters infected with Leishmania. Severe hepatic lesions were found in the animals infected with schistosome similar to that seen in human infection. These findings suggest the utilization of this animal as an experimental model of filariasis, leishmaniasis and schistosomiasis.
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spelling Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis Holochilus brasiliensis nanus Thomas, 1897: sugestão de modelo experimental para filariose, leishmaniose e esquistossomose Wild rodents classified as Holochilus brasiliensis nanus THOMAS, 1897, were captured in Lowland Region of State of Maranhão-Brazil. Natural infection by schistosome and filaria was detected in the most of these animals. Rodents born in the Animal House of the University of Maranhão were experimentally infected with Leishmania mexicana amazonensis or Schistosoma mansoni. Pathological aspects of leishmaniasis in these animals were found similar to that found in hamsters infected with Leishmania. Severe hepatic lesions were found in the animals infected with schistosome similar to that seen in human infection. These findings suggest the utilization of this animal as an experimental model of filariasis, leishmaniasis and schistosomiasis. Roedores silvestres, classificados como Holochilus brasiliensis nanus Thomas,1897, foram capturados na cidade de São Bento, pertencente à Região da Baixada, do Estado do Maranhão, Brasil, naturalmente infectados com formas adultas de filaria, na cavidade peritoneal, e microfilárias sangüíneas, assim como, com esquistossoma mansoni (vermes adultos e granulomas peri-ovulares hepáticos; intestinais; pulmonares; esplênicos e pancreáticos). Animais nascidos em Biotério, descendentes de Holochilus da Região da Baixada, foram infectados experimentalmente com Leishmania m. amazonensis e Schistosoma mansoni. Em observações semanais, foram encontradas lesões teciduais, semelhantes às que se desenvolvem em hamsters infectados com Leishmania, e hipergamaglobulinemia. Nos esquistossomóticos, foram constatadas hipergamaglobulinemia e reações granulomatosas similares às encontradas nos animais infectados naturalmente. Foram observadas, também, lesões hepática graves, semelhantes às encontradas na esquistossomose humana. Estes achados sugerem a utilização do Holochilus b. nanus como modelo experimental destas três doenças tropicais. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1984-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/87338Revista do Instituto de Medicina Tropical de São Paulo; Vol. 26 No. 6 (1984); 307-315Revista do Instituto de Medicina Tropical de São Paulo; Vol. 26 Núm. 6 (1984); 307-315Revista do Instituto de Medicina Tropical de São Paulo; v. 26 n. 6 (1984); 307-3151678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/87338/90297Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBastos, Othon de CarvalhoSadigursky, MoysésNascimento, Maria do Desterro Soares Brandão doBrazil, Reginaldo PeçanhaHolanda, João Carvalho de2014-11-07T16:06:55Zoai:revistas.usp.br:article/87338Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:21.988942Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis
Holochilus brasiliensis nanus Thomas, 1897: sugestão de modelo experimental para filariose, leishmaniose e esquistossomose
title Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis
spellingShingle Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis
Bastos, Othon de Carvalho
title_short Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis
title_full Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis
title_fullStr Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis
title_full_unstemmed Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis
title_sort Holochilus brasiliensis nanus Thomas, 1897: as an experimental model for filariasis, leishmaniasis and schistosomiasis
author Bastos, Othon de Carvalho
author_facet Bastos, Othon de Carvalho
Sadigursky, Moysés
Nascimento, Maria do Desterro Soares Brandão do
Brazil, Reginaldo Peçanha
Holanda, João Carvalho de
author_role author
author2 Sadigursky, Moysés
Nascimento, Maria do Desterro Soares Brandão do
Brazil, Reginaldo Peçanha
Holanda, João Carvalho de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bastos, Othon de Carvalho
Sadigursky, Moysés
Nascimento, Maria do Desterro Soares Brandão do
Brazil, Reginaldo Peçanha
Holanda, João Carvalho de
description Wild rodents classified as Holochilus brasiliensis nanus THOMAS, 1897, were captured in Lowland Region of State of Maranhão-Brazil. Natural infection by schistosome and filaria was detected in the most of these animals. Rodents born in the Animal House of the University of Maranhão were experimentally infected with Leishmania mexicana amazonensis or Schistosoma mansoni. Pathological aspects of leishmaniasis in these animals were found similar to that found in hamsters infected with Leishmania. Severe hepatic lesions were found in the animals infected with schistosome similar to that seen in human infection. These findings suggest the utilization of this animal as an experimental model of filariasis, leishmaniasis and schistosomiasis.
publishDate 1984
dc.date.none.fl_str_mv 1984-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/87338
url https://www.revistas.usp.br/rimtsp/article/view/87338
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/87338/90297
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 26 No. 6 (1984); 307-315
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 26 Núm. 6 (1984); 307-315
Revista do Instituto de Medicina Tropical de São Paulo; v. 26 n. 6 (1984); 307-315
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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