Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole
Autor(a) principal: | |
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Data de Publicação: | 1989 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28635 |
Resumo: | For the therapy of human strongyloidiasis, are necessary effective drugs to eliminate both larvae and adult worm parasitism, which may also be used by parenteral route, to obviate the particular conditions presented by many patients. A study based on the experimental infection by Strongyloides venezuelensis in rats was done, administering injectable ivermectin or levamizole. Both drugs were shown to be active, when used in single doses of 0.2 to 0.5 mg/kg of ivermectin, or 26 mg/kg for levamizole. Ivermectin was slightly more effective as far as larval stage of the infection is concerned, and the same happened for levamisole for the adult worm stage. Promising perspectives are visualized to improve the therapy of patients with serious disseminated infection by Strongyloides stercoralis. |
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Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole Tratamento da infecção experimental de ratos por Strongyloides venezuelensis mediante uso da ivermectina e do levamisol injetáveis Strongyloides venezuelensisInfecção experimental de ratosTratamentoIvermectina e levamisol injetáveis For the therapy of human strongyloidiasis, are necessary effective drugs to eliminate both larvae and adult worm parasitism, which may also be used by parenteral route, to obviate the particular conditions presented by many patients. A study based on the experimental infection by Strongyloides venezuelensis in rats was done, administering injectable ivermectin or levamizole. Both drugs were shown to be active, when used in single doses of 0.2 to 0.5 mg/kg of ivermectin, or 26 mg/kg for levamizole. Ivermectin was slightly more effective as far as larval stage of the infection is concerned, and the same happened for levamisole for the adult worm stage. Promising perspectives are visualized to improve the therapy of patients with serious disseminated infection by Strongyloides stercoralis. Para tratamento da estrongiloidíase humana disseminada são desejáveis medicamentos eficientes em debelar o parasitismo por larvas e vermes adultos e, aplicáveis também pela via parenteral, para contornar dificuldades motivadas pelo estado de determinados pacientes. Por isso, foi realizado estudo baseado na infecção experimental de ratos pelo Strongyloides venezuelensis e administração de ivermectina ou de levamisol injetáveis. Os dois fármacos mostraram-se ativos quando usados em doses únicas, de 0,2 a 0,5 mg/kg e 26 mg/kg, respectivamente, de ivermectina e levamisol, sendo que o primeiro revelou discreta superioridade para a fase larvária enquanto o segundo, para os helmintos adultos. Assim, ficaram delineadas promissoras perspectivas para aprimoramento da terapêutica capaz de beneficiar pacientes com infecção generalizada, comumente grave, devida ao Strongyloides stercoralis. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1989-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28635Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 1 (1989); 48-52 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 1 (1989); 48-52 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 1 (1989); 48-52 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28635/30488Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessCampos, RubensPinto, Pedro Luiz SilvaAmato Neto, VicenteMatsubara, LuísMiyamoto, AkimiCarvalho, Silvino Alves deTakiguti, Clóvis KiomitsuMoreira, Antonio Augusto Baillot2012-07-02T01:08:17Zoai:revistas.usp.br:article/28635Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:22.776772Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole Tratamento da infecção experimental de ratos por Strongyloides venezuelensis mediante uso da ivermectina e do levamisol injetáveis |
title |
Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole |
spellingShingle |
Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole Campos, Rubens Strongyloides venezuelensis Infecção experimental de ratos Tratamento Ivermectina e levamisol injetáveis |
title_short |
Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole |
title_full |
Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole |
title_fullStr |
Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole |
title_full_unstemmed |
Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole |
title_sort |
Therapy of the experimental infection by Strongyloides venezuelensis in rats with injectable ivermectin or levamizole |
author |
Campos, Rubens |
author_facet |
Campos, Rubens Pinto, Pedro Luiz Silva Amato Neto, Vicente Matsubara, Luís Miyamoto, Akimi Carvalho, Silvino Alves de Takiguti, Clóvis Kiomitsu Moreira, Antonio Augusto Baillot |
author_role |
author |
author2 |
Pinto, Pedro Luiz Silva Amato Neto, Vicente Matsubara, Luís Miyamoto, Akimi Carvalho, Silvino Alves de Takiguti, Clóvis Kiomitsu Moreira, Antonio Augusto Baillot |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Campos, Rubens Pinto, Pedro Luiz Silva Amato Neto, Vicente Matsubara, Luís Miyamoto, Akimi Carvalho, Silvino Alves de Takiguti, Clóvis Kiomitsu Moreira, Antonio Augusto Baillot |
dc.subject.por.fl_str_mv |
Strongyloides venezuelensis Infecção experimental de ratos Tratamento Ivermectina e levamisol injetáveis |
topic |
Strongyloides venezuelensis Infecção experimental de ratos Tratamento Ivermectina e levamisol injetáveis |
description |
For the therapy of human strongyloidiasis, are necessary effective drugs to eliminate both larvae and adult worm parasitism, which may also be used by parenteral route, to obviate the particular conditions presented by many patients. A study based on the experimental infection by Strongyloides venezuelensis in rats was done, administering injectable ivermectin or levamizole. Both drugs were shown to be active, when used in single doses of 0.2 to 0.5 mg/kg of ivermectin, or 26 mg/kg for levamizole. Ivermectin was slightly more effective as far as larval stage of the infection is concerned, and the same happened for levamisole for the adult worm stage. Promising perspectives are visualized to improve the therapy of patients with serious disseminated infection by Strongyloides stercoralis. |
publishDate |
1989 |
dc.date.none.fl_str_mv |
1989-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28635 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28635 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28635/30488 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 1 (1989); 48-52 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 1 (1989); 48-52 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 1 (1989); 48-52 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951637853667328 |