Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/189072 |
Resumo: | In December 2019, several cases of pneumonia of unknown origin were reported in the city of Wuhan, province of Hubei, China. The pathogen was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the disease was named coronavirus disease 2019 (COVID-19). Acute phase reactans (APRs) are critical in the early diagnosis, treatment, and for monitoring the progression of COVID-19. Seventy two patients were included in the study and infections confirmed by real-time reverse transcription polymerase chain reaction. Clinical parameters, the level of APFs and D-dimer were assessed and results were retrived from the patients’ medical records. Chest computed tomography (CT) findings were described for each patient and they were divided into two groups, with or without COVID-19 pneumonia. The correlation between APRs and CT findings and the patients’ prognosis were evaluated. Twenty eight (38.8%) of the 72 patients were female and 44 (61.2%) were male. The most common symptom was cough (43%) and the most common associated chronic disease was hypertension (12.5%). Thirty (41.6%) patients had completely normal chest CT, while 42 (58.4%) patients had typical findings in terms of COVID-19 pneumonia. C reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), ferritin, procalcitonin and D-Dimer levels were statistically significantly higher in patients with pneumonia than in those without pneumonia and these parameters were also statistically significantly higher in patients with severe illness. In conclusion, CRP, LDH, ESR, ferritin, and D-Dimer were associated with severe COVID-19 pneumonia. These biomarkers can be used to evaluate the prognosis to predict the clinical course of disease, allowing a proper management and treatment of the patients. |
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Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumoniaAcute phase reactansSARS-CoV-2COVID-19Computed tomographyPneumoniaIn December 2019, several cases of pneumonia of unknown origin were reported in the city of Wuhan, province of Hubei, China. The pathogen was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the disease was named coronavirus disease 2019 (COVID-19). Acute phase reactans (APRs) are critical in the early diagnosis, treatment, and for monitoring the progression of COVID-19. Seventy two patients were included in the study and infections confirmed by real-time reverse transcription polymerase chain reaction. Clinical parameters, the level of APFs and D-dimer were assessed and results were retrived from the patients’ medical records. Chest computed tomography (CT) findings were described for each patient and they were divided into two groups, with or without COVID-19 pneumonia. The correlation between APRs and CT findings and the patients’ prognosis were evaluated. Twenty eight (38.8%) of the 72 patients were female and 44 (61.2%) were male. The most common symptom was cough (43%) and the most common associated chronic disease was hypertension (12.5%). Thirty (41.6%) patients had completely normal chest CT, while 42 (58.4%) patients had typical findings in terms of COVID-19 pneumonia. C reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), ferritin, procalcitonin and D-Dimer levels were statistically significantly higher in patients with pneumonia than in those without pneumonia and these parameters were also statistically significantly higher in patients with severe illness. In conclusion, CRP, LDH, ESR, ferritin, and D-Dimer were associated with severe COVID-19 pneumonia. These biomarkers can be used to evaluate the prognosis to predict the clinical course of disease, allowing a proper management and treatment of the patients.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2021-08-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/18907210.1590/S1678-9946202163051Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e51Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e51Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e511678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/189072/174730Copyright (c) 2021 Asli Tanrivermis Sayit , Muzaffer Elmali, Aydın Deveci, Omer Gedikli https://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessSayit , Asli Tanrivermis Elmali, Muzaffer Deveci, Aydın Gedikli , Omer 2022-05-16T13:44:35Zoai:revistas.usp.br:article/189072Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:58.851391Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia |
title |
Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia |
spellingShingle |
Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia Sayit , Asli Tanrivermis Acute phase reactans SARS-CoV-2 COVID-19 Computed tomography Pneumonia |
title_short |
Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia |
title_full |
Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia |
title_fullStr |
Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia |
title_full_unstemmed |
Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia |
title_sort |
Relationship between acute phase reactants and prognosis in patients with or without COVID-19 pneumonia |
author |
Sayit , Asli Tanrivermis |
author_facet |
Sayit , Asli Tanrivermis Elmali, Muzaffer Deveci, Aydın Gedikli , Omer |
author_role |
author |
author2 |
Elmali, Muzaffer Deveci, Aydın Gedikli , Omer |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Sayit , Asli Tanrivermis Elmali, Muzaffer Deveci, Aydın Gedikli , Omer |
dc.subject.por.fl_str_mv |
Acute phase reactans SARS-CoV-2 COVID-19 Computed tomography Pneumonia |
topic |
Acute phase reactans SARS-CoV-2 COVID-19 Computed tomography Pneumonia |
description |
In December 2019, several cases of pneumonia of unknown origin were reported in the city of Wuhan, province of Hubei, China. The pathogen was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the disease was named coronavirus disease 2019 (COVID-19). Acute phase reactans (APRs) are critical in the early diagnosis, treatment, and for monitoring the progression of COVID-19. Seventy two patients were included in the study and infections confirmed by real-time reverse transcription polymerase chain reaction. Clinical parameters, the level of APFs and D-dimer were assessed and results were retrived from the patients’ medical records. Chest computed tomography (CT) findings were described for each patient and they were divided into two groups, with or without COVID-19 pneumonia. The correlation between APRs and CT findings and the patients’ prognosis were evaluated. Twenty eight (38.8%) of the 72 patients were female and 44 (61.2%) were male. The most common symptom was cough (43%) and the most common associated chronic disease was hypertension (12.5%). Thirty (41.6%) patients had completely normal chest CT, while 42 (58.4%) patients had typical findings in terms of COVID-19 pneumonia. C reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), ferritin, procalcitonin and D-Dimer levels were statistically significantly higher in patients with pneumonia than in those without pneumonia and these parameters were also statistically significantly higher in patients with severe illness. In conclusion, CRP, LDH, ESR, ferritin, and D-Dimer were associated with severe COVID-19 pneumonia. These biomarkers can be used to evaluate the prognosis to predict the clinical course of disease, allowing a proper management and treatment of the patients. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/189072 10.1590/S1678-9946202163051 |
url |
https://www.revistas.usp.br/rimtsp/article/view/189072 |
identifier_str_mv |
10.1590/S1678-9946202163051 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/189072/174730 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Asli Tanrivermis Sayit , Muzaffer Elmali, Aydın Deveci, Omer Gedikli https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Asli Tanrivermis Sayit , Muzaffer Elmali, Aydın Deveci, Omer Gedikli https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e51 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e51 Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e51 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
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Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
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Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
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