Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28924 |
Resumo: | Results of a HIV prevalence study conducted in hemophiliacs from Belo Horizonte, Brazil are presented. History of exposure to acellular blood components was determined for the five year period prior to entry in the study, which occurred during 1986 and 1987. Patients with coagulations disorders (hemophilia A = 132, hemophilia B = 16 and coagulation disorders other than hemophilia = 16) were transfused with liquid cryoprecipitate, locally produced, lyophilized cryoprecipitate, imported from São Paulo (Brazil) and factor VIII and IX, imported from Rio de Janeiro (Brazil), Europe, and United States. Thirty six (22%) tested HIV seropositive. The univariate and multivariate analysis (logistic model) demonstrated that the risk of HIV infection during the study period was associated with the total units of acellular blood components transfused. In addition, the proportional contribution of the individual components to the total acellular units transfused, namely a increase in factor VIII/IX and lyophilized cryoprecipitate proportions, were found to be associated with HIV seropositivity. This analysis suggest that not only the total amount of units was an important determinant of HIV infection, but that the risk was also associated with the specific component of blood transfused |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil Exposição de produtos do sangue, acelulares e o risco da infecção pelo VIH, em hemofílicos de Belo Horizonte, Brasil HemophiliacsHIVblood productsBrazil Results of a HIV prevalence study conducted in hemophiliacs from Belo Horizonte, Brazil are presented. History of exposure to acellular blood components was determined for the five year period prior to entry in the study, which occurred during 1986 and 1987. Patients with coagulations disorders (hemophilia A = 132, hemophilia B = 16 and coagulation disorders other than hemophilia = 16) were transfused with liquid cryoprecipitate, locally produced, lyophilized cryoprecipitate, imported from São Paulo (Brazil) and factor VIII and IX, imported from Rio de Janeiro (Brazil), Europe, and United States. Thirty six (22%) tested HIV seropositive. The univariate and multivariate analysis (logistic model) demonstrated that the risk of HIV infection during the study period was associated with the total units of acellular blood components transfused. In addition, the proportional contribution of the individual components to the total acellular units transfused, namely a increase in factor VIII/IX and lyophilized cryoprecipitate proportions, were found to be associated with HIV seropositivity. This analysis suggest that not only the total amount of units was an important determinant of HIV infection, but that the risk was also associated with the specific component of blood transfused Resultados de um estudo da prevalência de infecção pelo VIH, realizado em hemofílicos em Belo Horizonte são apresentados. História prévia de exposição a componentes acelulares do sangue foi determinada para o período de 5 anos anteriores à entrada no estudo, que transcorreu durante 1986 e 1987. Pacientes com distúrbios da coagulação (hemofilia A n = 132, hemofilia B n = 16 e outros distúrbios da coagulação que não hemofilia n = 16), foram transfundidos com crio-precipitado líquido, localmente produzido, crio-precipitado liofilizado, importado de São Paulo, e Fator VIII e IX, importado do Rio de Janeiro, Europa e Estados Unidos. Trinta e seis (22%) resultaram soropositivos para o VIH. A análise univariada e multivariada (regressão logística) demonstrou que o risco de infecção pelo VIH durante o período estudado, esteve associado ao total de unidades de componentes acelulares do sangue transfundidas. Além disto, a contribuição proporcional dos componentes individuais para o total de unidades acelulares transfundidas, isto é, um aumento na proporção de Fator VIII/IX e crioprecipitado liofilizado, demonstrou-se estar associado à soropositividade para o VIH. Este estudo sugere que não apenas a quantidade total de unidades transfundidas foi um importante determinante de soropositividade para o VIH, mas que o risco esteve também associado com o componente específico do sangue que foi transfundido Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1992-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28924Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 3 (1992); 227-232 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 3 (1992); 227-232 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 3 (1992); 227-232 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28924/30781Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessProietti, Fernando A.Proietti, Anna Barbara F. C.Costa, Maria Fernanda F. L.Antunes, Carlos M. F.Guimarães, Mark D. C.Paulino, Urquiza H. M.Souza, Caio J. C.Melo, LaércioMunõz, Álvaro2012-07-02T01:33:00Zoai:revistas.usp.br:article/28924Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:41.347811Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil Exposição de produtos do sangue, acelulares e o risco da infecção pelo VIH, em hemofílicos de Belo Horizonte, Brasil |
title |
Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil |
spellingShingle |
Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil Proietti, Fernando A. Hemophiliacs HIV blood products Brazil |
title_short |
Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil |
title_full |
Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil |
title_fullStr |
Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil |
title_full_unstemmed |
Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil |
title_sort |
Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil |
author |
Proietti, Fernando A. |
author_facet |
Proietti, Fernando A. Proietti, Anna Barbara F. C. Costa, Maria Fernanda F. L. Antunes, Carlos M. F. Guimarães, Mark D. C. Paulino, Urquiza H. M. Souza, Caio J. C. Melo, Laércio Munõz, Álvaro |
author_role |
author |
author2 |
Proietti, Anna Barbara F. C. Costa, Maria Fernanda F. L. Antunes, Carlos M. F. Guimarães, Mark D. C. Paulino, Urquiza H. M. Souza, Caio J. C. Melo, Laércio Munõz, Álvaro |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Proietti, Fernando A. Proietti, Anna Barbara F. C. Costa, Maria Fernanda F. L. Antunes, Carlos M. F. Guimarães, Mark D. C. Paulino, Urquiza H. M. Souza, Caio J. C. Melo, Laércio Munõz, Álvaro |
dc.subject.por.fl_str_mv |
Hemophiliacs HIV blood products Brazil |
topic |
Hemophiliacs HIV blood products Brazil |
description |
Results of a HIV prevalence study conducted in hemophiliacs from Belo Horizonte, Brazil are presented. History of exposure to acellular blood components was determined for the five year period prior to entry in the study, which occurred during 1986 and 1987. Patients with coagulations disorders (hemophilia A = 132, hemophilia B = 16 and coagulation disorders other than hemophilia = 16) were transfused with liquid cryoprecipitate, locally produced, lyophilized cryoprecipitate, imported from São Paulo (Brazil) and factor VIII and IX, imported from Rio de Janeiro (Brazil), Europe, and United States. Thirty six (22%) tested HIV seropositive. The univariate and multivariate analysis (logistic model) demonstrated that the risk of HIV infection during the study period was associated with the total units of acellular blood components transfused. In addition, the proportional contribution of the individual components to the total acellular units transfused, namely a increase in factor VIII/IX and lyophilized cryoprecipitate proportions, were found to be associated with HIV seropositivity. This analysis suggest that not only the total amount of units was an important determinant of HIV infection, but that the risk was also associated with the specific component of blood transfused |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28924 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28924 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28924/30781 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 3 (1992); 227-232 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 3 (1992); 227-232 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 3 (1992); 227-232 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
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Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
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Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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