The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
Autor(a) principal: | |
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Data de Publicação: | 1987 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28519 |
Resumo: | The inhibitor effect on the Glycogen synthetase (E.C.2.4.1.11) activity by four anthelmintics: Mebendazole, Parbendazole, Albendazole and Thiabendazole was determinated. The most inhibitor effect of Parbendazole on A. suum, F. hepatica and M. expansa, was observed. The lowest inhibitor effect of Thiabendazole, on all cases, was also observed. The aim of our study, and further studies on the same line, are to provide new reports about the unknown locus of actuation of these anthelmintics. |
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Revista do Instituto de Medicina Tropical de São Paulo |
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The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites Glucogeno sintasa en helmintos parasitos: inhibicion por benzimidazoles Glucógeno sintetasa - inhibicionParbendazolMebendazolAlbendazolTiabendaúolAscaris suumFasciola hepaticaMoniezia expansa The inhibitor effect on the Glycogen synthetase (E.C.2.4.1.11) activity by four anthelmintics: Mebendazole, Parbendazole, Albendazole and Thiabendazole was determinated. The most inhibitor effect of Parbendazole on A. suum, F. hepatica and M. expansa, was observed. The lowest inhibitor effect of Thiabendazole, on all cases, was also observed. The aim of our study, and further studies on the same line, are to provide new reports about the unknown locus of actuation of these anthelmintics. Se ha determinado el effecto inhibidor sobre la actividad Glucogeno sintetasa (E.C.2.41.11) por parte de cuatro antihelminticos: Albendazol, Mebendazol, Parbendazol y Tiabendazol. Observandose que en todos los casos, es el Parbendazol quien ha demostrado un mayor poder inhibidor sobre la glucógeno sintetasa de Ascaris suum, Fasciola hepatica y Moniezia expansa. El Tiabendazol es el anti-helmintico que menor efecto inhibidor ha presentado sobre la enzima en los tres parasitos objeto de nuestro estudio. Con el presente trabajo y otros previstos en la misma linea, se pretende aportar nuevos datos acerca del aun desconocido locus de acción de estos antihelminticos. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1987-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28519Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 4 (1987); 200-204 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 4 (1987); 200-204 Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 4 (1987); 200-204 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28519/30372Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessGomez-Banqueri, H.Garcia Ruiz, M. A.Monteoliva, M.Sanchez-Moreno, M.2012-07-02T00:57:36Zoai:revistas.usp.br:article/28519Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:14.966664Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites Glucogeno sintasa en helmintos parasitos: inhibicion por benzimidazoles |
title |
The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites |
spellingShingle |
The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites Gomez-Banqueri, H. Glucógeno sintetasa - inhibicion Parbendazol Mebendazol Albendazol Tiabendaúol Ascaris suum Fasciola hepatica Moniezia expansa |
title_short |
The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites |
title_full |
The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites |
title_fullStr |
The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites |
title_full_unstemmed |
The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites |
title_sort |
The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites |
author |
Gomez-Banqueri, H. |
author_facet |
Gomez-Banqueri, H. Garcia Ruiz, M. A. Monteoliva, M. Sanchez-Moreno, M. |
author_role |
author |
author2 |
Garcia Ruiz, M. A. Monteoliva, M. Sanchez-Moreno, M. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gomez-Banqueri, H. Garcia Ruiz, M. A. Monteoliva, M. Sanchez-Moreno, M. |
dc.subject.por.fl_str_mv |
Glucógeno sintetasa - inhibicion Parbendazol Mebendazol Albendazol Tiabendaúol Ascaris suum Fasciola hepatica Moniezia expansa |
topic |
Glucógeno sintetasa - inhibicion Parbendazol Mebendazol Albendazol Tiabendaúol Ascaris suum Fasciola hepatica Moniezia expansa |
description |
The inhibitor effect on the Glycogen synthetase (E.C.2.4.1.11) activity by four anthelmintics: Mebendazole, Parbendazole, Albendazole and Thiabendazole was determinated. The most inhibitor effect of Parbendazole on A. suum, F. hepatica and M. expansa, was observed. The lowest inhibitor effect of Thiabendazole, on all cases, was also observed. The aim of our study, and further studies on the same line, are to provide new reports about the unknown locus of actuation of these anthelmintics. |
publishDate |
1987 |
dc.date.none.fl_str_mv |
1987-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28519 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28519 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28519/30372 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 4 (1987); 200-204 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 4 (1987); 200-204 Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 4 (1987); 200-204 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
_version_ |
1798951637199355904 |