The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites

Detalhes bibliográficos
Autor(a) principal: Gomez-Banqueri, H.
Data de Publicação: 1987
Outros Autores: Garcia Ruiz, M. A., Monteoliva, M., Sanchez-Moreno, M.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28519
Resumo: The inhibitor effect on the Glycogen synthetase (E.C.2.4.1.11) activity by four anthelmintics: Mebendazole, Parbendazole, Albendazole and Thiabendazole was determinated. The most inhibitor effect of Parbendazole on A. suum, F. hepatica and M. expansa, was observed. The lowest inhibitor effect of Thiabendazole, on all cases, was also observed. The aim of our study, and further studies on the same line, are to provide new reports about the unknown locus of actuation of these anthelmintics.
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spelling The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites Glucogeno sintasa en helmintos parasitos: inhibicion por benzimidazoles Glucógeno sintetasa - inhibicionParbendazolMebendazolAlbendazolTiabendaúolAscaris suumFasciola hepaticaMoniezia expansa The inhibitor effect on the Glycogen synthetase (E.C.2.4.1.11) activity by four anthelmintics: Mebendazole, Parbendazole, Albendazole and Thiabendazole was determinated. The most inhibitor effect of Parbendazole on A. suum, F. hepatica and M. expansa, was observed. The lowest inhibitor effect of Thiabendazole, on all cases, was also observed. The aim of our study, and further studies on the same line, are to provide new reports about the unknown locus of actuation of these anthelmintics. Se ha determinado el effecto inhibidor sobre la actividad Glucogeno sintetasa (E.C.2.41.11) por parte de cuatro antihelminticos: Albendazol, Mebendazol, Parbendazol y Tiabendazol. Observandose que en todos los casos, es el Parbendazol quien ha demostrado un mayor poder inhibidor sobre la glucógeno sintetasa de Ascaris suum, Fasciola hepatica y Moniezia expansa. El Tiabendazol es el anti-helmintico que menor efecto inhibidor ha presentado sobre la enzima en los tres parasitos objeto de nuestro estudio. Con el presente trabajo y otros previstos en la misma linea, se pretende aportar nuevos datos acerca del aun desconocido locus de acción de estos antihelminticos. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1987-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28519Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 4 (1987); 200-204 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 4 (1987); 200-204 Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 4 (1987); 200-204 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28519/30372Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessGomez-Banqueri, H.Garcia Ruiz, M. A.Monteoliva, M.Sanchez-Moreno, M.2012-07-02T00:57:36Zoai:revistas.usp.br:article/28519Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:14.966664Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
Glucogeno sintasa en helmintos parasitos: inhibicion por benzimidazoles
title The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
spellingShingle The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
Gomez-Banqueri, H.
Glucógeno sintetasa - inhibicion
Parbendazol
Mebendazol
Albendazol
Tiabendaúol
Ascaris suum
Fasciola hepatica
Moniezia expansa
title_short The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
title_full The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
title_fullStr The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
title_full_unstemmed The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
title_sort The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites
author Gomez-Banqueri, H.
author_facet Gomez-Banqueri, H.
Garcia Ruiz, M. A.
Monteoliva, M.
Sanchez-Moreno, M.
author_role author
author2 Garcia Ruiz, M. A.
Monteoliva, M.
Sanchez-Moreno, M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Gomez-Banqueri, H.
Garcia Ruiz, M. A.
Monteoliva, M.
Sanchez-Moreno, M.
dc.subject.por.fl_str_mv Glucógeno sintetasa - inhibicion
Parbendazol
Mebendazol
Albendazol
Tiabendaúol
Ascaris suum
Fasciola hepatica
Moniezia expansa
topic Glucógeno sintetasa - inhibicion
Parbendazol
Mebendazol
Albendazol
Tiabendaúol
Ascaris suum
Fasciola hepatica
Moniezia expansa
description The inhibitor effect on the Glycogen synthetase (E.C.2.4.1.11) activity by four anthelmintics: Mebendazole, Parbendazole, Albendazole and Thiabendazole was determinated. The most inhibitor effect of Parbendazole on A. suum, F. hepatica and M. expansa, was observed. The lowest inhibitor effect of Thiabendazole, on all cases, was also observed. The aim of our study, and further studies on the same line, are to provide new reports about the unknown locus of actuation of these anthelmintics.
publishDate 1987
dc.date.none.fl_str_mv 1987-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28519
url https://www.revistas.usp.br/rimtsp/article/view/28519
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28519/30372
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 4 (1987); 200-204
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 4 (1987); 200-204
Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 4 (1987); 200-204
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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