Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis

Detalhes bibliográficos
Autor(a) principal: Bava, A. J.
Data de Publicação: 1994
Outros Autores: Negroni, R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/29218
Resumo: The efficacy of flucytosine (5-FC) and fluconazole (FLU) association in the treatment of a murine experimental model of cryptococcosis, was evaluated. Seven groups of 10 Balb C mice each, were intraperitoneally inoculated with 10(7) cells of Cryptococcus neoformans. Six groups were allocated to receive 5-FC (300 mg/kg) and FLU (16 mg/ kg), either combined and individually, by daily gavage beginning 5 days after the infection, for 2 and 4 weeks. One group received distilled water and was used as control. The evaluation of treatments was based on: survival time; macroscopic examination of brain, lungs, liver and spleen at autopsy; presence of capsulated yeasts in microscopic examination of wet preparations of these organs and cultures of brain homogenate. 5-FC and FLU, individually or combined, significantly prolonged the survival time of the treated animals with respect to the control group (p
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spelling Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis CryptococcosisExperimental cryptococcosisAntifungal drugs The efficacy of flucytosine (5-FC) and fluconazole (FLU) association in the treatment of a murine experimental model of cryptococcosis, was evaluated. Seven groups of 10 Balb C mice each, were intraperitoneally inoculated with 10(7) cells of Cryptococcus neoformans. Six groups were allocated to receive 5-FC (300 mg/kg) and FLU (16 mg/ kg), either combined and individually, by daily gavage beginning 5 days after the infection, for 2 and 4 weeks. One group received distilled water and was used as control. The evaluation of treatments was based on: survival time; macroscopic examination of brain, lungs, liver and spleen at autopsy; presence of capsulated yeasts in microscopic examination of wet preparations of these organs and cultures of brain homogenate. 5-FC and FLU, individually or combined, significantly prolonged the survival time of the treated animals with respect to the control group (pUniversidade de São Paulo. Instituto de Medicina Tropical de São Paulo1994-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29218Revista do Instituto de Medicina Tropical de São Paulo; Vol. 36 No. 6 (1994); 551-554 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 36 Núm. 6 (1994); 551-554 Revista do Instituto de Medicina Tropical de São Paulo; v. 36 n. 6 (1994); 551-554 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29218/31075Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBava, A. J.Negroni, R.2012-07-02T01:38:31Zoai:revistas.usp.br:article/29218Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:58.241576Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
title Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
spellingShingle Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
Bava, A. J.
Cryptococcosis
Experimental cryptococcosis
Antifungal drugs
title_short Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
title_full Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
title_fullStr Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
title_full_unstemmed Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
title_sort Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
author Bava, A. J.
author_facet Bava, A. J.
Negroni, R.
author_role author
author2 Negroni, R.
author2_role author
dc.contributor.author.fl_str_mv Bava, A. J.
Negroni, R.
dc.subject.por.fl_str_mv Cryptococcosis
Experimental cryptococcosis
Antifungal drugs
topic Cryptococcosis
Experimental cryptococcosis
Antifungal drugs
description The efficacy of flucytosine (5-FC) and fluconazole (FLU) association in the treatment of a murine experimental model of cryptococcosis, was evaluated. Seven groups of 10 Balb C mice each, were intraperitoneally inoculated with 10(7) cells of Cryptococcus neoformans. Six groups were allocated to receive 5-FC (300 mg/kg) and FLU (16 mg/ kg), either combined and individually, by daily gavage beginning 5 days after the infection, for 2 and 4 weeks. One group received distilled water and was used as control. The evaluation of treatments was based on: survival time; macroscopic examination of brain, lungs, liver and spleen at autopsy; presence of capsulated yeasts in microscopic examination of wet preparations of these organs and cultures of brain homogenate. 5-FC and FLU, individually or combined, significantly prolonged the survival time of the treated animals with respect to the control group (p
publishDate 1994
dc.date.none.fl_str_mv 1994-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/29218
url https://www.revistas.usp.br/rimtsp/article/view/29218
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/29218/31075
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 36 No. 6 (1994); 551-554
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 36 Núm. 6 (1994); 551-554
Revista do Instituto de Medicina Tropical de São Paulo; v. 36 n. 6 (1994); 551-554
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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