Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/29218 |
Resumo: | The efficacy of flucytosine (5-FC) and fluconazole (FLU) association in the treatment of a murine experimental model of cryptococcosis, was evaluated. Seven groups of 10 Balb C mice each, were intraperitoneally inoculated with 10(7) cells of Cryptococcus neoformans. Six groups were allocated to receive 5-FC (300 mg/kg) and FLU (16 mg/ kg), either combined and individually, by daily gavage beginning 5 days after the infection, for 2 and 4 weeks. One group received distilled water and was used as control. The evaluation of treatments was based on: survival time; macroscopic examination of brain, lungs, liver and spleen at autopsy; presence of capsulated yeasts in microscopic examination of wet preparations of these organs and cultures of brain homogenate. 5-FC and FLU, individually or combined, significantly prolonged the survival time of the treated animals with respect to the control group (p |
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Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis CryptococcosisExperimental cryptococcosisAntifungal drugs The efficacy of flucytosine (5-FC) and fluconazole (FLU) association in the treatment of a murine experimental model of cryptococcosis, was evaluated. Seven groups of 10 Balb C mice each, were intraperitoneally inoculated with 10(7) cells of Cryptococcus neoformans. Six groups were allocated to receive 5-FC (300 mg/kg) and FLU (16 mg/ kg), either combined and individually, by daily gavage beginning 5 days after the infection, for 2 and 4 weeks. One group received distilled water and was used as control. The evaluation of treatments was based on: survival time; macroscopic examination of brain, lungs, liver and spleen at autopsy; presence of capsulated yeasts in microscopic examination of wet preparations of these organs and cultures of brain homogenate. 5-FC and FLU, individually or combined, significantly prolonged the survival time of the treated animals with respect to the control group (pUniversidade de São Paulo. Instituto de Medicina Tropical de São Paulo1994-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29218Revista do Instituto de Medicina Tropical de São Paulo; Vol. 36 No. 6 (1994); 551-554 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 36 Núm. 6 (1994); 551-554 Revista do Instituto de Medicina Tropical de São Paulo; v. 36 n. 6 (1994); 551-554 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29218/31075Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBava, A. J.Negroni, R.2012-07-02T01:38:31Zoai:revistas.usp.br:article/29218Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:58.241576Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis |
title |
Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis |
spellingShingle |
Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis Bava, A. J. Cryptococcosis Experimental cryptococcosis Antifungal drugs |
title_short |
Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis |
title_full |
Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis |
title_fullStr |
Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis |
title_full_unstemmed |
Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis |
title_sort |
Flucytosine + fluconazole association in the treatment of a murine experimental model of cryptococcosis |
author |
Bava, A. J. |
author_facet |
Bava, A. J. Negroni, R. |
author_role |
author |
author2 |
Negroni, R. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Bava, A. J. Negroni, R. |
dc.subject.por.fl_str_mv |
Cryptococcosis Experimental cryptococcosis Antifungal drugs |
topic |
Cryptococcosis Experimental cryptococcosis Antifungal drugs |
description |
The efficacy of flucytosine (5-FC) and fluconazole (FLU) association in the treatment of a murine experimental model of cryptococcosis, was evaluated. Seven groups of 10 Balb C mice each, were intraperitoneally inoculated with 10(7) cells of Cryptococcus neoformans. Six groups were allocated to receive 5-FC (300 mg/kg) and FLU (16 mg/ kg), either combined and individually, by daily gavage beginning 5 days after the infection, for 2 and 4 weeks. One group received distilled water and was used as control. The evaluation of treatments was based on: survival time; macroscopic examination of brain, lungs, liver and spleen at autopsy; presence of capsulated yeasts in microscopic examination of wet preparations of these organs and cultures of brain homogenate. 5-FC and FLU, individually or combined, significantly prolonged the survival time of the treated animals with respect to the control group (p |
publishDate |
1994 |
dc.date.none.fl_str_mv |
1994-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29218 |
url |
https://www.revistas.usp.br/rimtsp/article/view/29218 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29218/31075 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 36 No. 6 (1994); 551-554 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 36 Núm. 6 (1994); 551-554 Revista do Instituto de Medicina Tropical de São Paulo; v. 36 n. 6 (1994); 551-554 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951641079087104 |