Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae

Detalhes bibliográficos
Autor(a) principal: Belda Junior, Walter
Data de Publicação: 2007
Outros Autores: Velho, Paulo Eduardo Neves Ferreira, Fagundes, Luiz Jorge, Arnone, Marcelo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31057
Resumo: Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not show anymore the expected therapeutic results because of aspects of chromosomal and plasmid-mediated resistance. The purpose of this study was to evaluate the susceptibility of Neisseria gonorrhoeae strains to six drugs used for its treatment (penicillin, tetracycline, cefoxitin, thiamphenicol, spectinomycin and ofloxacin) by the determination of minimal inhibitory concentrations of these drugs. We concluded that drugs, such as cefoxitin, thiamphenicol and spectinomycin still are excellent pharmacological agents for the treatment of gonorrhea. Penicillin, although still efficient, needs more attention regarding its use, as well as ofloxacin, because of the emergence of resistant strains. Tetracycline and its derivatives should be strongly contraindicated for the treatment of gonorrhea.
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spelling Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae GonorrheaNeisseria gonorrhoeaeDrug resistanceMinimum inhibitory concentration Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not show anymore the expected therapeutic results because of aspects of chromosomal and plasmid-mediated resistance. The purpose of this study was to evaluate the susceptibility of Neisseria gonorrhoeae strains to six drugs used for its treatment (penicillin, tetracycline, cefoxitin, thiamphenicol, spectinomycin and ofloxacin) by the determination of minimal inhibitory concentrations of these drugs. We concluded that drugs, such as cefoxitin, thiamphenicol and spectinomycin still are excellent pharmacological agents for the treatment of gonorrhea. Penicillin, although still efficient, needs more attention regarding its use, as well as ofloxacin, because of the emergence of resistant strains. Tetracycline and its derivatives should be strongly contraindicated for the treatment of gonorrhea. A utilização de antimicrobianos no tratamento da gonorréia iniciou-se em 1930 com a utilização das sulfonamidas. No decorrer dos anos outras drogas passaram a ser utilizadas em seu tratamento como a penicilina, tetraciclina, espectinomicina e outras. Embora altamente eficazes no início, essas drogas, ao longo do tempo, passaram a não mais apresentar o resultado terapêutico esperado em virtude do aparecimento de quadros de resistência cromossômica e plasmidial. Este trabalho teve por objetivo avaliar a sensibilidade de cepas de Neisseria gonorrhoeae a seis drogas utilizadas no seu tratamento (penicilina, tetraciclina, cefoxitina, tianfenicol, espectinomicina e ofloxacina) através da concentração inibitória mínima. Concluimos que drogas como a cefoxitina, o tianfenicol e a espectinomicina ainda constituem excelentes fármacos para o tratamento da gonorréia. A penicilina, embora ainda eficaz, enseja maiores cuidados na sua utilização, assim como a ofloxacina, frente ao surgimento de cepas resistentes e, a tetraciclina e seus derivados deve ser sobremaneira contra-indicada no tratamento da gonorréia. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2007-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31057Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 No. 1 (2007); 55-58 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 Núm. 1 (2007); 55-58 Revista do Instituto de Medicina Tropical de São Paulo; v. 49 n. 1 (2007); 55-58 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31057/32941Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBelda Junior, WalterVelho, Paulo Eduardo Neves FerreiraFagundes, Luiz JorgeArnone, Marcelo2012-07-07T18:59:20Zoai:revistas.usp.br:article/31057Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:45.633038Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae
Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae
title Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae
spellingShingle Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae
Belda Junior, Walter
Gonorrhea
Neisseria gonorrhoeae
Drug resistance
Minimum inhibitory concentration
title_short Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae
title_full Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae
title_fullStr Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae
title_full_unstemmed Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae
title_sort Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae
author Belda Junior, Walter
author_facet Belda Junior, Walter
Velho, Paulo Eduardo Neves Ferreira
Fagundes, Luiz Jorge
Arnone, Marcelo
author_role author
author2 Velho, Paulo Eduardo Neves Ferreira
Fagundes, Luiz Jorge
Arnone, Marcelo
author2_role author
author
author
dc.contributor.author.fl_str_mv Belda Junior, Walter
Velho, Paulo Eduardo Neves Ferreira
Fagundes, Luiz Jorge
Arnone, Marcelo
dc.subject.por.fl_str_mv Gonorrhea
Neisseria gonorrhoeae
Drug resistance
Minimum inhibitory concentration
topic Gonorrhea
Neisseria gonorrhoeae
Drug resistance
Minimum inhibitory concentration
description Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not show anymore the expected therapeutic results because of aspects of chromosomal and plasmid-mediated resistance. The purpose of this study was to evaluate the susceptibility of Neisseria gonorrhoeae strains to six drugs used for its treatment (penicillin, tetracycline, cefoxitin, thiamphenicol, spectinomycin and ofloxacin) by the determination of minimal inhibitory concentrations of these drugs. We concluded that drugs, such as cefoxitin, thiamphenicol and spectinomycin still are excellent pharmacological agents for the treatment of gonorrhea. Penicillin, although still efficient, needs more attention regarding its use, as well as ofloxacin, because of the emergence of resistant strains. Tetracycline and its derivatives should be strongly contraindicated for the treatment of gonorrhea.
publishDate 2007
dc.date.none.fl_str_mv 2007-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31057
url https://www.revistas.usp.br/rimtsp/article/view/31057
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31057/32941
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 No. 1 (2007); 55-58
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 Núm. 1 (2007); 55-58
Revista do Instituto de Medicina Tropical de São Paulo; v. 49 n. 1 (2007); 55-58
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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