"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil
Autor(a) principal: | |
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Data de Publicação: | 1989 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28658 |
Resumo: | Imipenem is a β lactam antibiotic, a highly potent new carbapenem with broad antibacterial spectrum. To test the "in vitro" efficacy of this antimicrobial agent in pathogens more frequent in several Medical Centers in Brazil, susceptibility testing with 10 meg imipenem disks and, or corresponding MIC were carried out with 1231 recent isolates of 41 different bacterial species, obtained mainly from hospitalized patients in 5 different medical centers of the cities of S. Paulo, Rio de Janeiro and Salvador. Our preliminary results with this antibiotic, in final phases of clinical and laboratorial experimentation in this country, are very promissing with, 96.79% of susceptibility of test isolates to 10 mcg imipenem disks and corresponding MIC correlation of up to 4 μg/ml. (92.31%). Of the 9 bacterial species more frequently isolated totaling 1108 (82%) of the 1230 test isolates, disk susceptibility was 99% (E. coli), 93% (Pseudomonas aeruginosas), 87% (Staphylococcus aureus), 100% (Klebsiella pneumoniae), 98% (Klebsiella sp), 97% (Proteus mirabiles), 94% (Enterobacter sp), 100% (Streptococcus faecalis) with good MIC correlation (up to 8 mcg/ml) and 100% for the anaerobic species Bacteroides sp (MIC up to 4 μg/ml). "In vitro" efficacy to hospital pathogens with high frequency of resistance to most antibiotics as Pseudomonas aeruginosa and to anaerobes notably Bacteroides sp is emphasized. |
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"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil Estudo da suscetibilidade "in vitro" a um novo antimicrobiano (IMIPENEM) de patógenos isolados de pacientes hospitalares em vários centros AntimicrobianoImipenemInfecções hospitalares Imipenem is a β lactam antibiotic, a highly potent new carbapenem with broad antibacterial spectrum. To test the "in vitro" efficacy of this antimicrobial agent in pathogens more frequent in several Medical Centers in Brazil, susceptibility testing with 10 meg imipenem disks and, or corresponding MIC were carried out with 1231 recent isolates of 41 different bacterial species, obtained mainly from hospitalized patients in 5 different medical centers of the cities of S. Paulo, Rio de Janeiro and Salvador. Our preliminary results with this antibiotic, in final phases of clinical and laboratorial experimentation in this country, are very promissing with, 96.79% of susceptibility of test isolates to 10 mcg imipenem disks and corresponding MIC correlation of up to 4 μg/ml. (92.31%). Of the 9 bacterial species more frequently isolated totaling 1108 (82%) of the 1230 test isolates, disk susceptibility was 99% (E. coli), 93% (Pseudomonas aeruginosas), 87% (Staphylococcus aureus), 100% (Klebsiella pneumoniae), 98% (Klebsiella sp), 97% (Proteus mirabiles), 94% (Enterobacter sp), 100% (Streptococcus faecalis) with good MIC correlation (up to 8 mcg/ml) and 100% for the anaerobic species Bacteroides sp (MIC up to 4 μg/ml). "In vitro" efficacy to hospital pathogens with high frequency of resistance to most antibiotics as Pseudomonas aeruginosa and to anaerobes notably Bacteroides sp is emphasized. O imipenem é um novo antibiótico Beta lactâmico, carbapenêmico, altamente potente e com amplo espectro de atividade antimicrobiana. Com intuito de comprovar a eficácia "in vitro" deste fármaco em patógenos mais freqüentes em nosso meio, descrevem os autores, os resultados das provas de suscetibilidade por discos e/ou a correspondência por provas de diluição para determinação da concentração inibitória mínima (CIM) em 1230 cepas compreendendo 41 diferentes espécies bacterianas recém-isoladas, principalmente de pacientes hospitalares em 5 diferentes centros médicos de Sáo Paulo, Rio de Janeiro e Salvador. Nossos resultados preliminares com o antibiótico, em fase final de experimentação clínica e laboratorial, em nosso meio, foram muito promissores, com 96.79% de cepas suscetíveis pela prova do disco (10 μg de imipenem) e 92,31% de correspondência pela determinação do CIM (concentrações de até 4μg/ml). Das 9 espécies bacterianas mais freqüentemente isoladas, correspondendo a 1008 (82%) das 1230 cepas de nosso material, as sensibilidades pela prova do disco foram de 99% (E. coli), 93% (Pseudomonas aeruginosas), 87% (Staphylococcus aureus), 100% (Klebsiella pneumoniae), 98% (Klebsiella sp) e 100% (Streptococcus faecalis) com boa correspondência pela determinação do CIM até 8μg/ml; e 100% para o anaeróbio Bacteróides sp (CIM até 4μg/ml). Ressaltam os autores a eficácia "in vitro" contra patógenos hospitalares que apresentam elevados índices de resistência à grande maioria de antibióticos como o Pseudomonas aeruginosa e para anaeróbios, notadamente o Bacteróides sp. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1989-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28658Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 3 (1989); 169-176 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 3 (1989); 169-176 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 3 (1989); 169-176 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28658/30511Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessGodoy, Cid Vieira Franco deMendes, Caio Mareio FigueiredoMímica, IgorOliveira, Moema deSuassuna, ItaloUzeda, Milton de2012-07-02T01:09:37Zoai:revistas.usp.br:article/28658Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:24.243680Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil Estudo da suscetibilidade "in vitro" a um novo antimicrobiano (IMIPENEM) de patógenos isolados de pacientes hospitalares em vários centros |
title |
"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil |
spellingShingle |
"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil Godoy, Cid Vieira Franco de Antimicrobiano Imipenem Infecções hospitalares |
title_short |
"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil |
title_full |
"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil |
title_fullStr |
"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil |
title_full_unstemmed |
"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil |
title_sort |
"In vitro" efficacy of a new antimicrobial agent (IMIPENEM) in pathogens isolated from hospitalized patients from several Medical Centers in Brazil |
author |
Godoy, Cid Vieira Franco de |
author_facet |
Godoy, Cid Vieira Franco de Mendes, Caio Mareio Figueiredo Mímica, Igor Oliveira, Moema de Suassuna, Italo Uzeda, Milton de |
author_role |
author |
author2 |
Mendes, Caio Mareio Figueiredo Mímica, Igor Oliveira, Moema de Suassuna, Italo Uzeda, Milton de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Godoy, Cid Vieira Franco de Mendes, Caio Mareio Figueiredo Mímica, Igor Oliveira, Moema de Suassuna, Italo Uzeda, Milton de |
dc.subject.por.fl_str_mv |
Antimicrobiano Imipenem Infecções hospitalares |
topic |
Antimicrobiano Imipenem Infecções hospitalares |
description |
Imipenem is a β lactam antibiotic, a highly potent new carbapenem with broad antibacterial spectrum. To test the "in vitro" efficacy of this antimicrobial agent in pathogens more frequent in several Medical Centers in Brazil, susceptibility testing with 10 meg imipenem disks and, or corresponding MIC were carried out with 1231 recent isolates of 41 different bacterial species, obtained mainly from hospitalized patients in 5 different medical centers of the cities of S. Paulo, Rio de Janeiro and Salvador. Our preliminary results with this antibiotic, in final phases of clinical and laboratorial experimentation in this country, are very promissing with, 96.79% of susceptibility of test isolates to 10 mcg imipenem disks and corresponding MIC correlation of up to 4 μg/ml. (92.31%). Of the 9 bacterial species more frequently isolated totaling 1108 (82%) of the 1230 test isolates, disk susceptibility was 99% (E. coli), 93% (Pseudomonas aeruginosas), 87% (Staphylococcus aureus), 100% (Klebsiella pneumoniae), 98% (Klebsiella sp), 97% (Proteus mirabiles), 94% (Enterobacter sp), 100% (Streptococcus faecalis) with good MIC correlation (up to 8 mcg/ml) and 100% for the anaerobic species Bacteroides sp (MIC up to 4 μg/ml). "In vitro" efficacy to hospital pathogens with high frequency of resistance to most antibiotics as Pseudomonas aeruginosa and to anaerobes notably Bacteroides sp is emphasized. |
publishDate |
1989 |
dc.date.none.fl_str_mv |
1989-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28658 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28658 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28658/30511 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 3 (1989); 169-176 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 3 (1989); 169-176 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 3 (1989); 169-176 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951638182920192 |