"In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites

Detalhes bibliográficos
Autor(a) principal: Yang, Shen Lin
Data de Publicação: 1988
Outros Autores: Di Santi, Silvia Maria, Amato Neto, Vicente, Moreira, Antonio Augusto Baillot, Pinto, Pedro Luiz Silva, Boulos, Marcos, Campos, Rubens, Sant'Ana, Eunice José de, Shiroma, Mario
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28553
Resumo: In order to investigate whether gentian violet exhibited "in vitro" inhibitory activity against Plasmodium falciparum, the Authors have carried out 20 sensitivity tests according to the microtechnique described by RIECK MANN et al.5. Results have shown inhibition of schizonts'maturation at the following concentration: 1/1000; 1/1500; 1/2000; 1/2500; 1/3000 and 1/4000, thus demonstrating inhibitory activity of the tested dye against asexual blood parasites. The present data suggest gentain violet may be possibly used in the prophylaxis of transfusion-acquired malaria.
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spelling "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites Ação, "in vitro". Da violeta de genciana sobre formas evolutivas do plasmodium falciparum Plasmodium falciparumVioleta de genciana - ação "in vitro"Malária transfusional-profilaxia In order to investigate whether gentian violet exhibited "in vitro" inhibitory activity against Plasmodium falciparum, the Authors have carried out 20 sensitivity tests according to the microtechnique described by RIECK MANN et al.5. Results have shown inhibition of schizonts'maturation at the following concentration: 1/1000; 1/1500; 1/2000; 1/2500; 1/3000 and 1/4000, thus demonstrating inhibitory activity of the tested dye against asexual blood parasites. The present data suggest gentain violet may be possibly used in the prophylaxis of transfusion-acquired malaria. Utilizando a técnica de RIECKMANN e col.5, os autores realizaram 20 microtestes de sensibilidade, procurando verificar a capacidade da violeta de genciana em impedir, na cultura "in vitro", o desenvolvimento habitual do Plasmodium falciparum. Os resultados mostraram que houve inibiçáo da evolução do protozoário nas concentrações de 1/1000, 1/1500, 1/2000, 1/2500, 1/3000 e 1/4000, significando que nas condições da experiência o corante atuou sobre as formas sangüíneas assexuadas do protozoário. Estas verificações sugerem que a violeta de genciana poderia ser usada na profilaxia da malária transfusional. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1988-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28553Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 1 (1988); 17-20 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 1 (1988); 17-20 Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 1 (1988); 17-20 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28553/30406Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessYang, Shen LinDi Santi, Silvia MariaAmato Neto, VicenteMoreira, Antonio Augusto BaillotPinto, Pedro Luiz SilvaBoulos, MarcosCampos, RubensSant'Ana, Eunice José deShiroma, Mario2012-07-02T01:04:03Zoai:revistas.usp.br:article/28553Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:17.297768Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites
Ação, "in vitro". Da violeta de genciana sobre formas evolutivas do plasmodium falciparum
title "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites
spellingShingle "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites
Yang, Shen Lin
Plasmodium falciparum
Violeta de genciana - ação "in vitro"
Malária transfusional-profilaxia
title_short "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites
title_full "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites
title_fullStr "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites
title_full_unstemmed "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites
title_sort "In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites
author Yang, Shen Lin
author_facet Yang, Shen Lin
Di Santi, Silvia Maria
Amato Neto, Vicente
Moreira, Antonio Augusto Baillot
Pinto, Pedro Luiz Silva
Boulos, Marcos
Campos, Rubens
Sant'Ana, Eunice José de
Shiroma, Mario
author_role author
author2 Di Santi, Silvia Maria
Amato Neto, Vicente
Moreira, Antonio Augusto Baillot
Pinto, Pedro Luiz Silva
Boulos, Marcos
Campos, Rubens
Sant'Ana, Eunice José de
Shiroma, Mario
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Yang, Shen Lin
Di Santi, Silvia Maria
Amato Neto, Vicente
Moreira, Antonio Augusto Baillot
Pinto, Pedro Luiz Silva
Boulos, Marcos
Campos, Rubens
Sant'Ana, Eunice José de
Shiroma, Mario
dc.subject.por.fl_str_mv Plasmodium falciparum
Violeta de genciana - ação "in vitro"
Malária transfusional-profilaxia
topic Plasmodium falciparum
Violeta de genciana - ação "in vitro"
Malária transfusional-profilaxia
description In order to investigate whether gentian violet exhibited "in vitro" inhibitory activity against Plasmodium falciparum, the Authors have carried out 20 sensitivity tests according to the microtechnique described by RIECK MANN et al.5. Results have shown inhibition of schizonts'maturation at the following concentration: 1/1000; 1/1500; 1/2000; 1/2500; 1/3000 and 1/4000, thus demonstrating inhibitory activity of the tested dye against asexual blood parasites. The present data suggest gentain violet may be possibly used in the prophylaxis of transfusion-acquired malaria.
publishDate 1988
dc.date.none.fl_str_mv 1988-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28553
url https://www.revistas.usp.br/rimtsp/article/view/28553
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28553/30406
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 1 (1988); 17-20
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 1 (1988); 17-20
Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 1 (1988); 17-20
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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