Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/218909 |
Resumo: | Isoniazid is a key component of tuberculosis treatment. Adequate exposure is a determinant for therapeutic success; however, considerable inter- and intraindividual variations in drug plasma levels can lead to unfavorable outcomes. While some predictors of isoniazid levels are well-known, others, such as sex, yield controversial results, requiring further investigation to optimize exposure. This study investigates whether the sex of patients influences the dose administered and the concentrations of isoniazid in plasma. Levels of isoniazid were associated with the N-acetyltransferase 2 phenotypes. A total of 76 male and 58 female patients were included. Isoniazid was measured by high-performance liquid chromatography, and N-acetyltransferase 2 phenotypes were assessed using molecular techniques. The results show that the dose administered, expressed in mg/kg, was higher in females, but the plasma levels were similar between both sexes. Among patients, 46.2%, 38.8%, and 15% were slow, intermediate, and fast acetylators, respectively. As expected, isoniazid levels were associated with the acetylation phenotypes, with higher concentrations in the slow acetylators. Thus, sex-related difference in isoniazid levels is due to the body weight of patients, and the optimized dose regimen based on patient weight and acetylator phenotypes can improve the treatment outcomes. |
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Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosisTuberculosisIsoniazidInfectious diseasesDrug monitoringAntituberculosis drugsIsoniazid is a key component of tuberculosis treatment. Adequate exposure is a determinant for therapeutic success; however, considerable inter- and intraindividual variations in drug plasma levels can lead to unfavorable outcomes. While some predictors of isoniazid levels are well-known, others, such as sex, yield controversial results, requiring further investigation to optimize exposure. This study investigates whether the sex of patients influences the dose administered and the concentrations of isoniazid in plasma. Levels of isoniazid were associated with the N-acetyltransferase 2 phenotypes. A total of 76 male and 58 female patients were included. Isoniazid was measured by high-performance liquid chromatography, and N-acetyltransferase 2 phenotypes were assessed using molecular techniques. The results show that the dose administered, expressed in mg/kg, was higher in females, but the plasma levels were similar between both sexes. Among patients, 46.2%, 38.8%, and 15% were slow, intermediate, and fast acetylators, respectively. As expected, isoniazid levels were associated with the acetylation phenotypes, with higher concentrations in the slow acetylators. Thus, sex-related difference in isoniazid levels is due to the body weight of patients, and the optimized dose regimen based on patient weight and acetylator phenotypes can improve the treatment outcomes.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2023-11-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/21890910.1590/S1678-9946202365056Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e56Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e56Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e561678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/218909/199952Copyright (c) 2023 Juan Gonzalo Bardalez Rivera, Carlos Augusto Abreu Albério, José Luiz Fernandes Vieirahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessRivera, Juan Gonzalo Bardalez Albério, Carlos Augusto Abreu Vieira, José Luiz Fernandes 2023-12-20T14:25:40Zoai:revistas.usp.br:article/218909Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2023-12-20T14:25:40Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false |
dc.title.none.fl_str_mv |
Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis |
title |
Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis |
spellingShingle |
Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis Rivera, Juan Gonzalo Bardalez Tuberculosis Isoniazid Infectious diseases Drug monitoring Antituberculosis drugs |
title_short |
Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis |
title_full |
Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis |
title_fullStr |
Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis |
title_full_unstemmed |
Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis |
title_sort |
Influence of sex on the exposure to isoniazid in patients with pulmonary tuberculosis |
author |
Rivera, Juan Gonzalo Bardalez |
author_facet |
Rivera, Juan Gonzalo Bardalez Albério, Carlos Augusto Abreu Vieira, José Luiz Fernandes |
author_role |
author |
author2 |
Albério, Carlos Augusto Abreu Vieira, José Luiz Fernandes |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Rivera, Juan Gonzalo Bardalez Albério, Carlos Augusto Abreu Vieira, José Luiz Fernandes |
dc.subject.por.fl_str_mv |
Tuberculosis Isoniazid Infectious diseases Drug monitoring Antituberculosis drugs |
topic |
Tuberculosis Isoniazid Infectious diseases Drug monitoring Antituberculosis drugs |
description |
Isoniazid is a key component of tuberculosis treatment. Adequate exposure is a determinant for therapeutic success; however, considerable inter- and intraindividual variations in drug plasma levels can lead to unfavorable outcomes. While some predictors of isoniazid levels are well-known, others, such as sex, yield controversial results, requiring further investigation to optimize exposure. This study investigates whether the sex of patients influences the dose administered and the concentrations of isoniazid in plasma. Levels of isoniazid were associated with the N-acetyltransferase 2 phenotypes. A total of 76 male and 58 female patients were included. Isoniazid was measured by high-performance liquid chromatography, and N-acetyltransferase 2 phenotypes were assessed using molecular techniques. The results show that the dose administered, expressed in mg/kg, was higher in females, but the plasma levels were similar between both sexes. Among patients, 46.2%, 38.8%, and 15% were slow, intermediate, and fast acetylators, respectively. As expected, isoniazid levels were associated with the acetylation phenotypes, with higher concentrations in the slow acetylators. Thus, sex-related difference in isoniazid levels is due to the body weight of patients, and the optimized dose regimen based on patient weight and acetylator phenotypes can improve the treatment outcomes. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/218909 10.1590/S1678-9946202365056 |
url |
https://www.revistas.usp.br/rimtsp/article/view/218909 |
identifier_str_mv |
10.1590/S1678-9946202365056 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/218909/199952 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e56 Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e56 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e56 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951636616347648 |