Experimental coccidioidomycosis in the immunosuppressed rat
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28937 |
Resumo: | C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells were transferred from infected CY-treated to infected untreated rats, achieving significant specific inhibition in footpad swelling to coccidioidin in recipients, attributable to a suppressor T cell subpopulation induced by greater fungal antigen concentration arising from widespread C. immitis dissemination in immunosuppressed animals. NK activity proved similar regardless of CY treatment. Lastly, chronically infected rats presented increased colony forming units count after several weekly doses of CY, as happens in immunosuppressed patients harbouring a previous infection. |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Experimental coccidioidomycosis in the immunosuppressed rat Coccidioidomicose experimental em ratos imunossuprimidos RatCoccidioidomycosisCyclophosphamideImmunosuppressionT suppressor cellsReactivation C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells were transferred from infected CY-treated to infected untreated rats, achieving significant specific inhibition in footpad swelling to coccidioidin in recipients, attributable to a suppressor T cell subpopulation induced by greater fungal antigen concentration arising from widespread C. immitis dissemination in immunosuppressed animals. NK activity proved similar regardless of CY treatment. Lastly, chronically infected rats presented increased colony forming units count after several weekly doses of CY, as happens in immunosuppressed patients harbouring a previous infection. Ratos adultos inoculados com C. immitis desenvolveram infecção circunscrita ao pulmão sem apresentar mortalidade; no entanto, ao serem imunossuprimidos com CY apresentaram disseminação fúngica em vários órgãos, ausência de granulomas e depressão na resposta celular à coccidioidina junto com uma mortalidade de 50%. Tentou-se determinar os mecanismos envolvidos neste comportamento. Para isso foram medidas as atividades dos linfócitos supressores e células NK. Ao serem transferidos esplenócitos de animais infectados e tratados com CY a ratos somente infectados conseguiu-se significativa inibição específica da resposta à coccidioidina. Este efeito seria devido a uma subpopulação de linfócitos T supressores induzida por maior concentração de antígeno nos animais imunossuprimidos. A atividade NK foi semelhante nos ratos infectados independentemente do tratamento com CY. Por outro lado, tentou-se a reativação da infecção crônica com C. immitis. Os animais infectados apresentaram maior quantidade de unidades formadoras de colônias nos pulmões depois de várias doses semanais de CY, assim como ocorre em pacientes que apresentam deficiências a nível imunológico. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1992-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28937Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 4 (1992); 303-307 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 4 (1992); 303-307 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 4 (1992); 303-307 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28937/30794Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessRemesar, Mirta C.Blejer, Jorgelina L.Negroni, RicardoNejamkis, Marta R.2012-07-02T01:33:14Zoai:revistas.usp.br:article/28937Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:42.159912Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Experimental coccidioidomycosis in the immunosuppressed rat Coccidioidomicose experimental em ratos imunossuprimidos |
title |
Experimental coccidioidomycosis in the immunosuppressed rat |
spellingShingle |
Experimental coccidioidomycosis in the immunosuppressed rat Remesar, Mirta C. Rat Coccidioidomycosis Cyclophosphamide Immunosuppression T suppressor cells Reactivation |
title_short |
Experimental coccidioidomycosis in the immunosuppressed rat |
title_full |
Experimental coccidioidomycosis in the immunosuppressed rat |
title_fullStr |
Experimental coccidioidomycosis in the immunosuppressed rat |
title_full_unstemmed |
Experimental coccidioidomycosis in the immunosuppressed rat |
title_sort |
Experimental coccidioidomycosis in the immunosuppressed rat |
author |
Remesar, Mirta C. |
author_facet |
Remesar, Mirta C. Blejer, Jorgelina L. Negroni, Ricardo Nejamkis, Marta R. |
author_role |
author |
author2 |
Blejer, Jorgelina L. Negroni, Ricardo Nejamkis, Marta R. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Remesar, Mirta C. Blejer, Jorgelina L. Negroni, Ricardo Nejamkis, Marta R. |
dc.subject.por.fl_str_mv |
Rat Coccidioidomycosis Cyclophosphamide Immunosuppression T suppressor cells Reactivation |
topic |
Rat Coccidioidomycosis Cyclophosphamide Immunosuppression T suppressor cells Reactivation |
description |
C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells were transferred from infected CY-treated to infected untreated rats, achieving significant specific inhibition in footpad swelling to coccidioidin in recipients, attributable to a suppressor T cell subpopulation induced by greater fungal antigen concentration arising from widespread C. immitis dissemination in immunosuppressed animals. NK activity proved similar regardless of CY treatment. Lastly, chronically infected rats presented increased colony forming units count after several weekly doses of CY, as happens in immunosuppressed patients harbouring a previous infection. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28937 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28937 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28937/30794 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 4 (1992); 303-307 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 4 (1992); 303-307 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 4 (1992); 303-307 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951639462182912 |