Avaliação dos marcadores indiretos na infecção pelo vírus da imunodeficiência humana (HIV) entre doadores de sangue do hemocentro do "Hospital Universitário Regional Norte do Paraná", Londrina, PR, Brasil

• Autor(a) principal: Reiche, Edna Maria Vissoci
• Data de Publicação: 2003
• Outros Autores: Vogler, Ingridt Hildegard, Morimoto, Helena Kaminami, Bortoliero, André Luis, Matsuo, Tiemi, Yuahasi, Kátia Kioko, Cancian, Sanderson Júnior, Koguichi, Roberto Setsuo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
• Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/30665
• topic: Surrogate markers; Human immunodeficiency virus infection (HIV); Blood donors; Serological screening; Anti-HBc; Anti-HCV

This study evaluated the usefulness of the anti-HBc, hepatitis C virus antibodies (anti-HCV), human T cell lymphotropic virus I and II antibodies (anti-HTLV I/II), serologic tests for syphilis, and surface antigen of hepatitis B virus (HBsAg) as surrogate markers for the risk for HIV infection in 80,284 serum samples from blood donors from the Blood Bank of "Hospital Universitário Regional Norte do Paraná", Londrina, Paraná State, Brazil, analyzed from July 1994 to April 2001. Among 39 blood donors with positive serology for HIV, 12 (30.8%) were anti-HBc positive, 10 (25.6%) for anti-HCV, 1 (2.6%) for anti-HTLV I/I, 1 (2.6%) was positive for syphilis, and 1 (2.6%) for HBsAg. Among the donors with negative serology for HIV, these markers were detected in 8,407 (10.5%), 441 (0.5%), 189 (0.2%), 464 (0.6%), and 473 (0.6%) samples, respectively. The difference was statistically significant (p < 0.001) for anti-HBc and anti-HCV. Although the predictive positive value for these surrogate markers were low for HIV infection, the results confirmed the anti-HBc and anti-HCV as useful surrogate markers for HIV infection thus reinforcing the maintenance of them in the screening for blood donors contributing to the prevention of the small number of cases in which HIV is still transmitted by transfusion.