Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral

Detalhes bibliográficos
Autor(a) principal: Pereira, Patricia da Silva Fucuta
Data de Publicação: 2009
Outros Autores: Silva, Ivonete Sandra de Souza e, Uehara, Silvia Naomi de Oliveira, Emori, Christini Takemi, Lanzoni, Valéria Pereira, Silva, Antonio Eduardo Benedito, Ferraz, Maria Lucia Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31227
Resumo: The complex interaction between hepatitis C virus infection, iron homeostasis and the response to antiviral treatment remains controversial. The aim of this study was to evaluate the influence of hepatic iron concentration (HIC) on the sustained virological response (SVR) to antiviral therapy in patients with chronic hepatitis C. A total of 50 patients who underwent pretreatment liver biopsy with assessment of HIC by graphite furnace atomic absorption spectroscopy and were subsequently submitted to antiviral treatment with interferon/peginterferon and ribavirin were included in the study. Patients with alcoholism, history of multiple blood transfusion, chronic kidney disease, hemolytic anemia and parenteral iron therapy were excluded. The iron related markers and HIC were compared between those who achieved an SVR and non-responders (NR) patients. The mean age was 45.7 years and the proportion of patients' gender was not different between SVR and NR patients. The median serum iron was 138 and 134 µg/dL (p = 0.9), the median serum ferritin was 152.5 and 179.5 ng/mL (p = 0.87) and the median HIC was 9.9 and 8.2 µmol/g dry tissue (p = 0.51), for SVR and NR patients, respectively. Thus, hepatic iron concentration, determined by a reliable quantitative method, was not a negative predictive factor of SVR in patients with chronic hepatitis C presenting mild to moderate hepatic iron accumulation.
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spelling Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral Chronic hepatitis C: hepatic iron content does not correlate with response to antiviral therapy IronHepatitis C virusInterferonPeginterferonRibavirinLiver biopsy The complex interaction between hepatitis C virus infection, iron homeostasis and the response to antiviral treatment remains controversial. The aim of this study was to evaluate the influence of hepatic iron concentration (HIC) on the sustained virological response (SVR) to antiviral therapy in patients with chronic hepatitis C. A total of 50 patients who underwent pretreatment liver biopsy with assessment of HIC by graphite furnace atomic absorption spectroscopy and were subsequently submitted to antiviral treatment with interferon/peginterferon and ribavirin were included in the study. Patients with alcoholism, history of multiple blood transfusion, chronic kidney disease, hemolytic anemia and parenteral iron therapy were excluded. The iron related markers and HIC were compared between those who achieved an SVR and non-responders (NR) patients. The mean age was 45.7 years and the proportion of patients' gender was not different between SVR and NR patients. The median serum iron was 138 and 134 µg/dL (p = 0.9), the median serum ferritin was 152.5 and 179.5 ng/mL (p = 0.87) and the median HIC was 9.9 and 8.2 µmol/g dry tissue (p = 0.51), for SVR and NR patients, respectively. Thus, hepatic iron concentration, determined by a reliable quantitative method, was not a negative predictive factor of SVR in patients with chronic hepatitis C presenting mild to moderate hepatic iron accumulation. A complexa interação entre infecção pelo vírus da hepatite C, homeostase do ferro e resposta ao tratamento antiviral permanece controversa. O objetivo deste estudo foi avaliar a influência da concentração hepática de ferro (CHF) na resposta virológica sustentada (RVS) à terapia antiviral na hepatite C crônica. Foram incluídos 50 pacientes que foram submetidos à biopsia hepática pré-tratamento com determinação da CHF por espectrofotometria de absorção atômica com forno de grafite e tratados posteriormente com interferon/peginterferon e ribavirina. Pacientes com alcoolismo, história de múltiplas transfusões sanguíneas, doença renal crônica, anemia hemolítica e terapia com ferro parenteral foram excluídos. O perfil de ferro sérico e a CHF foram comparados entre aqueles que atingiram RVS e os não-respondedores (NR). A média de idade dos pacientes foi 45,7 anos e não houve diferença na proporção de homens e mulheres entre os grupos RVS e NR. A mediana do ferro sérico foi 138 and 134 µg/dL (p = 0.9), a mediana da ferritina sérica foi 152,5 e 179,5 ng/mL (p = 0,87) e a CHF mediana foi 9,9 e 8,2 µmol/g de tecido seco (p = 0,51), para pacientes com RVS e NR, respectivamente. Concluindo, a concentração hepática de ferro, determinada por um método quantitativo confiável, não foi um fator preditivo negativo de RVS em pacientes com hepatite C crônica e acúmulo de ferro hepático leve a moderado. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31227Revista do Instituto de Medicina Tropical de São Paulo; Vol. 51 No. 6 (2009); 331-336 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 51 Núm. 6 (2009); 331-336 Revista do Instituto de Medicina Tropical de São Paulo; v. 51 n. 6 (2009); 331-336 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31227/33111Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessPereira, Patricia da Silva FucutaSilva, Ivonete Sandra de Souza eUehara, Silvia Naomi de OliveiraEmori, Christini TakemiLanzoni, Valéria PereiraSilva, Antonio Eduardo BeneditoFerraz, Maria Lucia Gomes2012-07-07T19:19:21Zoai:revistas.usp.br:article/31227Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:54.629387Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
Chronic hepatitis C: hepatic iron content does not correlate with response to antiviral therapy
title Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
spellingShingle Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
Pereira, Patricia da Silva Fucuta
Iron
Hepatitis C virus
Interferon
Peginterferon
Ribavirin
Liver biopsy
title_short Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
title_full Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
title_fullStr Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
title_full_unstemmed Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
title_sort Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
author Pereira, Patricia da Silva Fucuta
author_facet Pereira, Patricia da Silva Fucuta
Silva, Ivonete Sandra de Souza e
Uehara, Silvia Naomi de Oliveira
Emori, Christini Takemi
Lanzoni, Valéria Pereira
Silva, Antonio Eduardo Benedito
Ferraz, Maria Lucia Gomes
author_role author
author2 Silva, Ivonete Sandra de Souza e
Uehara, Silvia Naomi de Oliveira
Emori, Christini Takemi
Lanzoni, Valéria Pereira
Silva, Antonio Eduardo Benedito
Ferraz, Maria Lucia Gomes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Patricia da Silva Fucuta
Silva, Ivonete Sandra de Souza e
Uehara, Silvia Naomi de Oliveira
Emori, Christini Takemi
Lanzoni, Valéria Pereira
Silva, Antonio Eduardo Benedito
Ferraz, Maria Lucia Gomes
dc.subject.por.fl_str_mv Iron
Hepatitis C virus
Interferon
Peginterferon
Ribavirin
Liver biopsy
topic Iron
Hepatitis C virus
Interferon
Peginterferon
Ribavirin
Liver biopsy
description The complex interaction between hepatitis C virus infection, iron homeostasis and the response to antiviral treatment remains controversial. The aim of this study was to evaluate the influence of hepatic iron concentration (HIC) on the sustained virological response (SVR) to antiviral therapy in patients with chronic hepatitis C. A total of 50 patients who underwent pretreatment liver biopsy with assessment of HIC by graphite furnace atomic absorption spectroscopy and were subsequently submitted to antiviral treatment with interferon/peginterferon and ribavirin were included in the study. Patients with alcoholism, history of multiple blood transfusion, chronic kidney disease, hemolytic anemia and parenteral iron therapy were excluded. The iron related markers and HIC were compared between those who achieved an SVR and non-responders (NR) patients. The mean age was 45.7 years and the proportion of patients' gender was not different between SVR and NR patients. The median serum iron was 138 and 134 µg/dL (p = 0.9), the median serum ferritin was 152.5 and 179.5 ng/mL (p = 0.87) and the median HIC was 9.9 and 8.2 µmol/g dry tissue (p = 0.51), for SVR and NR patients, respectively. Thus, hepatic iron concentration, determined by a reliable quantitative method, was not a negative predictive factor of SVR in patients with chronic hepatitis C presenting mild to moderate hepatic iron accumulation.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31227
url https://www.revistas.usp.br/rimtsp/article/view/31227
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31227/33111
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 51 No. 6 (2009); 331-336
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 51 Núm. 6 (2009); 331-336
Revista do Instituto de Medicina Tropical de São Paulo; v. 51 n. 6 (2009); 331-336
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
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reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
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