Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/31227 |
Resumo: | The complex interaction between hepatitis C virus infection, iron homeostasis and the response to antiviral treatment remains controversial. The aim of this study was to evaluate the influence of hepatic iron concentration (HIC) on the sustained virological response (SVR) to antiviral therapy in patients with chronic hepatitis C. A total of 50 patients who underwent pretreatment liver biopsy with assessment of HIC by graphite furnace atomic absorption spectroscopy and were subsequently submitted to antiviral treatment with interferon/peginterferon and ribavirin were included in the study. Patients with alcoholism, history of multiple blood transfusion, chronic kidney disease, hemolytic anemia and parenteral iron therapy were excluded. The iron related markers and HIC were compared between those who achieved an SVR and non-responders (NR) patients. The mean age was 45.7 years and the proportion of patients' gender was not different between SVR and NR patients. The median serum iron was 138 and 134 µg/dL (p = 0.9), the median serum ferritin was 152.5 and 179.5 ng/mL (p = 0.87) and the median HIC was 9.9 and 8.2 µmol/g dry tissue (p = 0.51), for SVR and NR patients, respectively. Thus, hepatic iron concentration, determined by a reliable quantitative method, was not a negative predictive factor of SVR in patients with chronic hepatitis C presenting mild to moderate hepatic iron accumulation. |
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Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral Chronic hepatitis C: hepatic iron content does not correlate with response to antiviral therapy IronHepatitis C virusInterferonPeginterferonRibavirinLiver biopsy The complex interaction between hepatitis C virus infection, iron homeostasis and the response to antiviral treatment remains controversial. The aim of this study was to evaluate the influence of hepatic iron concentration (HIC) on the sustained virological response (SVR) to antiviral therapy in patients with chronic hepatitis C. A total of 50 patients who underwent pretreatment liver biopsy with assessment of HIC by graphite furnace atomic absorption spectroscopy and were subsequently submitted to antiviral treatment with interferon/peginterferon and ribavirin were included in the study. Patients with alcoholism, history of multiple blood transfusion, chronic kidney disease, hemolytic anemia and parenteral iron therapy were excluded. The iron related markers and HIC were compared between those who achieved an SVR and non-responders (NR) patients. The mean age was 45.7 years and the proportion of patients' gender was not different between SVR and NR patients. The median serum iron was 138 and 134 µg/dL (p = 0.9), the median serum ferritin was 152.5 and 179.5 ng/mL (p = 0.87) and the median HIC was 9.9 and 8.2 µmol/g dry tissue (p = 0.51), for SVR and NR patients, respectively. Thus, hepatic iron concentration, determined by a reliable quantitative method, was not a negative predictive factor of SVR in patients with chronic hepatitis C presenting mild to moderate hepatic iron accumulation. A complexa interação entre infecção pelo vírus da hepatite C, homeostase do ferro e resposta ao tratamento antiviral permanece controversa. O objetivo deste estudo foi avaliar a influência da concentração hepática de ferro (CHF) na resposta virológica sustentada (RVS) à terapia antiviral na hepatite C crônica. Foram incluídos 50 pacientes que foram submetidos à biopsia hepática pré-tratamento com determinação da CHF por espectrofotometria de absorção atômica com forno de grafite e tratados posteriormente com interferon/peginterferon e ribavirina. Pacientes com alcoolismo, história de múltiplas transfusões sanguíneas, doença renal crônica, anemia hemolítica e terapia com ferro parenteral foram excluídos. O perfil de ferro sérico e a CHF foram comparados entre aqueles que atingiram RVS e os não-respondedores (NR). A média de idade dos pacientes foi 45,7 anos e não houve diferença na proporção de homens e mulheres entre os grupos RVS e NR. A mediana do ferro sérico foi 138 and 134 µg/dL (p = 0.9), a mediana da ferritina sérica foi 152,5 e 179,5 ng/mL (p = 0,87) e a CHF mediana foi 9,9 e 8,2 µmol/g de tecido seco (p = 0,51), para pacientes com RVS e NR, respectivamente. Concluindo, a concentração hepática de ferro, determinada por um método quantitativo confiável, não foi um fator preditivo negativo de RVS em pacientes com hepatite C crônica e acúmulo de ferro hepático leve a moderado. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31227Revista do Instituto de Medicina Tropical de São Paulo; Vol. 51 No. 6 (2009); 331-336 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 51 Núm. 6 (2009); 331-336 Revista do Instituto de Medicina Tropical de São Paulo; v. 51 n. 6 (2009); 331-336 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31227/33111Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessPereira, Patricia da Silva FucutaSilva, Ivonete Sandra de Souza eUehara, Silvia Naomi de OliveiraEmori, Christini TakemiLanzoni, Valéria PereiraSilva, Antonio Eduardo BeneditoFerraz, Maria Lucia Gomes2012-07-07T19:19:21Zoai:revistas.usp.br:article/31227Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:54.629387Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral Chronic hepatitis C: hepatic iron content does not correlate with response to antiviral therapy |
title |
Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral |
spellingShingle |
Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral Pereira, Patricia da Silva Fucuta Iron Hepatitis C virus Interferon Peginterferon Ribavirin Liver biopsy |
title_short |
Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral |
title_full |
Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral |
title_fullStr |
Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral |
title_full_unstemmed |
Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral |
title_sort |
Hepatite C crônica: concentração hepática de ferro não é correlacionada com a resposta ao tratamento antiviral |
author |
Pereira, Patricia da Silva Fucuta |
author_facet |
Pereira, Patricia da Silva Fucuta Silva, Ivonete Sandra de Souza e Uehara, Silvia Naomi de Oliveira Emori, Christini Takemi Lanzoni, Valéria Pereira Silva, Antonio Eduardo Benedito Ferraz, Maria Lucia Gomes |
author_role |
author |
author2 |
Silva, Ivonete Sandra de Souza e Uehara, Silvia Naomi de Oliveira Emori, Christini Takemi Lanzoni, Valéria Pereira Silva, Antonio Eduardo Benedito Ferraz, Maria Lucia Gomes |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Patricia da Silva Fucuta Silva, Ivonete Sandra de Souza e Uehara, Silvia Naomi de Oliveira Emori, Christini Takemi Lanzoni, Valéria Pereira Silva, Antonio Eduardo Benedito Ferraz, Maria Lucia Gomes |
dc.subject.por.fl_str_mv |
Iron Hepatitis C virus Interferon Peginterferon Ribavirin Liver biopsy |
topic |
Iron Hepatitis C virus Interferon Peginterferon Ribavirin Liver biopsy |
description |
The complex interaction between hepatitis C virus infection, iron homeostasis and the response to antiviral treatment remains controversial. The aim of this study was to evaluate the influence of hepatic iron concentration (HIC) on the sustained virological response (SVR) to antiviral therapy in patients with chronic hepatitis C. A total of 50 patients who underwent pretreatment liver biopsy with assessment of HIC by graphite furnace atomic absorption spectroscopy and were subsequently submitted to antiviral treatment with interferon/peginterferon and ribavirin were included in the study. Patients with alcoholism, history of multiple blood transfusion, chronic kidney disease, hemolytic anemia and parenteral iron therapy were excluded. The iron related markers and HIC were compared between those who achieved an SVR and non-responders (NR) patients. The mean age was 45.7 years and the proportion of patients' gender was not different between SVR and NR patients. The median serum iron was 138 and 134 µg/dL (p = 0.9), the median serum ferritin was 152.5 and 179.5 ng/mL (p = 0.87) and the median HIC was 9.9 and 8.2 µmol/g dry tissue (p = 0.51), for SVR and NR patients, respectively. Thus, hepatic iron concentration, determined by a reliable quantitative method, was not a negative predictive factor of SVR in patients with chronic hepatitis C presenting mild to moderate hepatic iron accumulation. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/31227 |
url |
https://www.revistas.usp.br/rimtsp/article/view/31227 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/31227/33111 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 51 No. 6 (2009); 331-336 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 51 Núm. 6 (2009); 331-336 Revista do Instituto de Medicina Tropical de São Paulo; v. 51 n. 6 (2009); 331-336 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951646959501312 |