Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease

Detalhes bibliográficos
Autor(a) principal: Lomba, Guilherme Schittine Bezerra
Data de Publicação: 2024
Outros Autores: Silva, Pedro Henrique Abreu da, Rosário, Natalia Fonseca do, Medeiros, Thalia, Alves, Lilian Santos, Silva, Andrea Alice, Almeida, Jorge Reis, Lugon, Jocemir Ronaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/221515
Resumo: In Brazil, the COVID-19 burden was substantial, and risk factors associated with higher in-hospital mortality rates have been extensively studied. However, information on short-term all-cause mortality and the factors associated with death in patients who survived the hospitalization period of acute SARS-CoV-2 infection is limited. We analyzed the six-month post-hospitalization mortality rate and possible risk factors of COVID-19 patients in a single center in Brazil. This is a retrospective cohort study focused on a six-month follow-up. The exclusion criteria were death during hospitalization, transference to another hospital, and age under 18. We collected data from the charts of all hospitalized patients from March 2020 to December 2020 with a positive RT-PCR test for SARS-CoV-2, resulting in a sample size of 106 patients. The main outcome was death after hospitalization, whereas comorbidities and demographics were evaluated as risk factors. The crude post-hospitalization death rate was 16%. The first 30 days of follow-up had the highest mortality rate. In a Cox regression model for post-hospitalization mortality, previous chronic kidney disease (HR, 4.06, 95%CI 1.46 – 11.30) and longer hospital stay (HR 1.01, 95%CI 1.00 – 1.02) were the only factors statistically associated with death. In conclusion, a high six-month all-cause mortality was observed. Within the six-month follow-up, a higher risk of death was observed for patients who had prior CKD and longer hospital stay. These findings highlight the importance of more intensive medical surveillance during this period.
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spelling Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney diseaseCOVID-19MortalityChronic kidney diseaseHospitalizationDischargeIn Brazil, the COVID-19 burden was substantial, and risk factors associated with higher in-hospital mortality rates have been extensively studied. However, information on short-term all-cause mortality and the factors associated with death in patients who survived the hospitalization period of acute SARS-CoV-2 infection is limited. We analyzed the six-month post-hospitalization mortality rate and possible risk factors of COVID-19 patients in a single center in Brazil. This is a retrospective cohort study focused on a six-month follow-up. The exclusion criteria were death during hospitalization, transference to another hospital, and age under 18. We collected data from the charts of all hospitalized patients from March 2020 to December 2020 with a positive RT-PCR test for SARS-CoV-2, resulting in a sample size of 106 patients. The main outcome was death after hospitalization, whereas comorbidities and demographics were evaluated as risk factors. The crude post-hospitalization death rate was 16%. The first 30 days of follow-up had the highest mortality rate. In a Cox regression model for post-hospitalization mortality, previous chronic kidney disease (HR, 4.06, 95%CI 1.46 – 11.30) and longer hospital stay (HR 1.01, 95%CI 1.00 – 1.02) were the only factors statistically associated with death. In conclusion, a high six-month all-cause mortality was observed. Within the six-month follow-up, a higher risk of death was observed for patients who had prior CKD and longer hospital stay. These findings highlight the importance of more intensive medical surveillance during this period.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2024-01-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/22151510.1590/S1678-9946202466001Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e01Revista do Instituto de Medicina Tropical de São Paulo; v. 66 (2024); e01Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e011678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/221515/202625Copyright (c) 2024 Guilherme Schittine Bezerra Lomba, Pedro Henrique Abreu da Silva, Natalia Fonseca do Rosário, Thalia Medeiros, Lilian Santos Alves, Andrea Alice Silva, Jorge Reis Almeida, Jocemir Ronaldo Lugonhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessLomba, Guilherme Schittine Bezerra Silva, Pedro Henrique Abreu da Rosário, Natalia Fonseca do Medeiros, Thalia Alves, Lilian Santos Silva, Andrea Alice Almeida, Jorge Reis Lugon, Jocemir Ronaldo2024-05-06T14:04:51Zoai:revistas.usp.br:article/221515Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2024-05-06T14:04:51Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false
dc.title.none.fl_str_mv Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
title Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
spellingShingle Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
Lomba, Guilherme Schittine Bezerra
COVID-19
Mortality
Chronic kidney disease
Hospitalization
Discharge
title_short Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
title_full Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
title_fullStr Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
title_full_unstemmed Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
title_sort Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
author Lomba, Guilherme Schittine Bezerra
author_facet Lomba, Guilherme Schittine Bezerra
Silva, Pedro Henrique Abreu da
Rosário, Natalia Fonseca do
Medeiros, Thalia
Alves, Lilian Santos
Silva, Andrea Alice
Almeida, Jorge Reis
Lugon, Jocemir Ronaldo
author_role author
author2 Silva, Pedro Henrique Abreu da
Rosário, Natalia Fonseca do
Medeiros, Thalia
Alves, Lilian Santos
Silva, Andrea Alice
Almeida, Jorge Reis
Lugon, Jocemir Ronaldo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lomba, Guilherme Schittine Bezerra
Silva, Pedro Henrique Abreu da
Rosário, Natalia Fonseca do
Medeiros, Thalia
Alves, Lilian Santos
Silva, Andrea Alice
Almeida, Jorge Reis
Lugon, Jocemir Ronaldo
dc.subject.por.fl_str_mv COVID-19
Mortality
Chronic kidney disease
Hospitalization
Discharge
topic COVID-19
Mortality
Chronic kidney disease
Hospitalization
Discharge
description In Brazil, the COVID-19 burden was substantial, and risk factors associated with higher in-hospital mortality rates have been extensively studied. However, information on short-term all-cause mortality and the factors associated with death in patients who survived the hospitalization period of acute SARS-CoV-2 infection is limited. We analyzed the six-month post-hospitalization mortality rate and possible risk factors of COVID-19 patients in a single center in Brazil. This is a retrospective cohort study focused on a six-month follow-up. The exclusion criteria were death during hospitalization, transference to another hospital, and age under 18. We collected data from the charts of all hospitalized patients from March 2020 to December 2020 with a positive RT-PCR test for SARS-CoV-2, resulting in a sample size of 106 patients. The main outcome was death after hospitalization, whereas comorbidities and demographics were evaluated as risk factors. The crude post-hospitalization death rate was 16%. The first 30 days of follow-up had the highest mortality rate. In a Cox regression model for post-hospitalization mortality, previous chronic kidney disease (HR, 4.06, 95%CI 1.46 – 11.30) and longer hospital stay (HR 1.01, 95%CI 1.00 – 1.02) were the only factors statistically associated with death. In conclusion, a high six-month all-cause mortality was observed. Within the six-month follow-up, a higher risk of death was observed for patients who had prior CKD and longer hospital stay. These findings highlight the importance of more intensive medical surveillance during this period.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/221515
10.1590/S1678-9946202466001
url https://www.revistas.usp.br/rimtsp/article/view/221515
identifier_str_mv 10.1590/S1678-9946202466001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/221515/202625
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e01
Revista do Instituto de Medicina Tropical de São Paulo; v. 66 (2024); e01
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e01
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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