Chagas disease cardiomyopathy: current concepts of an old disease

Detalhes bibliográficos
Autor(a) principal: Bilate, Angelina M.B.
Data de Publicação: 2008
Outros Autores: Cunha-Neto, Edecio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31154
Resumo: Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy.
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spelling Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga Chagas diseaseCardiomyopathyAutoimmune diseasePathogenesis Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy. A doença de Chagas continua sendo importante problema de saúde pública uma vez que cerca de 10 milhões de indivíduos ainda estão infectados pelo T. cruzi. Décadas após a infecção primária, aproximadamente 30% dos indivíduos podem desenvolver uma cardiomiopatia inflamatória crônica, a chamada Cardiomiopatia Chagásica Crônica (CCC). Dados de modelos murinos e de estudos em humanos apóiam a visão de que tanto respostas auto-imunes como as determinadas pelo parasita em conjunto com citocinas e quimiocinas inflamatórias participam da geração das lesões cardíacas típicas da CCC. A presente revisão tem como objetivo sumarizar os recentes avanços no entendimento da imunopatogênese da Cardiomiopatia Chagásica Crônica. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31154Revista do Instituto de Medicina Tropical de São Paulo; Vol. 50 No. 2 (2008); 67-74 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 50 Núm. 2 (2008); 67-74 Revista do Instituto de Medicina Tropical de São Paulo; v. 50 n. 2 (2008); 67-74 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31154/33038Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBilate, Angelina M.B.Cunha-Neto, Edecio2012-07-07T19:07:39Zoai:revistas.usp.br:article/31154Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:50.809919Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Chagas disease cardiomyopathy: current concepts of an old disease
Cardiomiopatia chagásica: conceitos atuais de doença antiga
title Chagas disease cardiomyopathy: current concepts of an old disease
spellingShingle Chagas disease cardiomyopathy: current concepts of an old disease
Bilate, Angelina M.B.
Chagas disease
Cardiomyopathy
Autoimmune disease
Pathogenesis
title_short Chagas disease cardiomyopathy: current concepts of an old disease
title_full Chagas disease cardiomyopathy: current concepts of an old disease
title_fullStr Chagas disease cardiomyopathy: current concepts of an old disease
title_full_unstemmed Chagas disease cardiomyopathy: current concepts of an old disease
title_sort Chagas disease cardiomyopathy: current concepts of an old disease
author Bilate, Angelina M.B.
author_facet Bilate, Angelina M.B.
Cunha-Neto, Edecio
author_role author
author2 Cunha-Neto, Edecio
author2_role author
dc.contributor.author.fl_str_mv Bilate, Angelina M.B.
Cunha-Neto, Edecio
dc.subject.por.fl_str_mv Chagas disease
Cardiomyopathy
Autoimmune disease
Pathogenesis
topic Chagas disease
Cardiomyopathy
Autoimmune disease
Pathogenesis
description Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy.
publishDate 2008
dc.date.none.fl_str_mv 2008-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31154
url https://www.revistas.usp.br/rimtsp/article/view/31154
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31154/33038
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 50 No. 2 (2008); 67-74
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 50 Núm. 2 (2008); 67-74
Revista do Instituto de Medicina Tropical de São Paulo; v. 50 n. 2 (2008); 67-74
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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